Lysine Requirements of Healthy Pregnant Women are Higher During Late Stages of Gestation Compared to Early Gestation

Payne, Magdalene; Stephens, Trina; Lim, Kenneth; Ball, Ronald O.; Pencharz, Paul B.; Elango, Rajavel

doi:10.1093/jn/nxx034

Cited by 27 publications

(23 citation statements)

References 38 publications

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“…Lastly, a recent study on healthy pregnant women in Canada reported that the protein requirement could be higher than the current DRI recommendation [ 39 ]. The same research group subsequently showed increased requirements of specific indispensable amino acids, such as lysine and phenylalanine, during pregnancy [ 40 , 41 ]. Thus, caution may be necessary to view the risk of FGR and LBW in the context of maternal protein intake.…”

Section: Discussionmentioning

confidence: 99%

Maternal Serum Albumin Redox State Is Associated with Infant Birth Weight in Japanese Pregnant Women

et al. 2021

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Background: Plasma albumin (ALB) reflects protein nutritional status in rats, but it is not clear whether it is associated with dietary protein insufficiency in pregnant women and/or their risk of low birth weight delivery. This study aimed to investigate whether maternal serum ALB redox state reflects maternal protein nutritional status and/or is associated with infant birth weights. Methods: The relationship between the serum reduced ALB ratio and infant birth weight was examined in an observational study of 229 Japanese pregnant women. A rat model simulating fetal growth restriction, induced by protein-energy restriction, was used to elucidate the relationship between maternal nutritional status, maternal serum ALB redox state, and birth weight of the offspring. Results: In the human study, serum reduced ALB ratio in the third trimester was significantly and positively correlated with infant birth weight. In the rat study, serum reduced ALB ratio and birth weight in the litter decreased as the degree of protein-energy restriction intensified, and a significant and positive correlation was observed between them in late pregnancy. Conclusions: Maternal serum reduced ALB ratio in the third trimester is positively associated with infant birth weight in Japanese pregnant women, which would be mediated by maternal protein nutritional status.

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Section: Discussionmentioning

confidence: 99%

Maternal Serum Albumin Redox State Is Associated with Infant Birth Weight in Japanese Pregnant Women

et al. 2021

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“…To separate a potential confounding factor of prior familiarity of QPP and its nutritional characteristics compared to commercialized varieties, the taste test was held at Colby Community College in Colby, Kansas and participants were asked to rate six popcorn varieties based solely on sensory factors without prior knowledge of QPP's higher levels of essential amino acids lysine and tryptophan in the popped flake compared to commercialized varieties (Parsons et al, 2020). This specific increase in these two deficient amino acids in maize allows QPP to be considered a complete protein source, a “Functional Food”, or a food with an inclusion of certain substances with proven health benefits, and a “superfood”, or a relatively more nutrient dense and healthy product (Curll, Parker, MacGregor, & Petersen, 2016; Ghosh et al, 2008, 2010; MacGregor, Petersen, & Parker, 2018; Meyerding, Kürzdörfer, & Gassler, 2018; Murphy, Longhitano, Ayres, Cowen, & Harmer, 2006; Payne et al, 2018; Ritze, Bárdos, Hubert, & Bischoff, 2013; Tahergorabi, Matak, & Jaczynski, 2015).…”

Section: Discussionmentioning

confidence: 99%

Improved taste and texture in novel popcorn varieties compared to conventional lines

Parsons

Rodrı́guez

Holding

2021

Journal of Sensory Studies

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Quality Protein Popcorn (QPP) varieties were bred out of a unique germplasm pool derived from Quality Protein dent Maize and conventional popcorn lines. To identify and compare distinctive characteristics within this population, a new sensory method was employed that coupled hedonic numeric rankings of common sensory traits appearance, aroma, texture, and taste with an "overall likability" score while requiring the selection of specific descriptors for taste and texture. Participants tasted six popcorn cultivars, rated each sample based on sensory factors, and offered specific descriptors for taste and texture. This sensory method identified two QPP hybrids with higher overall likability rankings likely attributed to the diversified and improved taste and texture of QPP compared to the controls. The experimental design employed for this descriptive analysis was successful in identifying trait correlations, potential consumer preferences, and ranking of product acceptability and may serve as an efficient model for other sensory studies. Practical ApplicationQuality Protein Popcorn cultivars are novel products due to their unique genetic composition of elite popcorn and Quality Protein Maize dent maize. To evaluate consumer acceptability of these novel products, a new method for the sensory evaluation of common traits-appearance, aroma, texture, taste, and overall likability-was generated to identify desirable popcorn hybrids and correlations between overall likability and certain sensory attributes. Utilizing a numerical ranking system and categorical key descriptors, this study identified desirable popcorn characteristics and suggested explanations for these attributes. The evaluation format and experimental design employed enabled the identification of significant differences, trends, and correlations between traits and overall likability in a tested population of 112. These methods are easily transferable and may serve as an efficient model for other sensory studies identifying trait correlations, consumer preferences, and ranking of product acceptability.

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“…Protein requirements are increased from early pregnancy and increase throughout gestation [ 8 , 19 ]. Contemporary methods such as in vivo amino acid oxidation suggest previous estimates of gestational protein requirements, based historically from extrapolation of nitrogen balance studies in men, may be insufficient, especially in late pregnancy, Fig.…”

Section: Biological Adaptations To Pregnancymentioning

confidence: 99%

Impact of pregnancy on inborn errors of metabolism

Wilcox

2018

Rev Endocr Metab Disord

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Once based mainly in paediatrics, inborn errors of metabolism (IEM), or inherited metabolic disorders (IMD) represent a growing adult medicine specialty. Individually rare these conditions have currently, a collective estimated prevalence of >1:800. Diagnosis has improved through expanded newborn screening programs, identification of potentially affected family members and greater awareness of symptomatic presentations in adolescence and in adulthood. Better survival and reduced mortality from previously lethal and debilitating conditions means greater numbers transition to adulthood. Pregnancy, once contraindicated for many, may represent a challenging but successful outcome. Successful pregnancies are now reported in a wide range of IEM. Significant challenges remain, given the biological stresses of pregnancy, parturition and the puerperium. Known diagnoses allow preventive and pre-emptive management. Unrecognized metabolic disorders especially, remain a preventable cause of maternal and neonatal mortality and morbidity. Increased awareness of these conditions amongst all clinicians is essential to expedite diagnosis and manage appropriately. This review aims to describe normal adaptations to pregnancy and discuss how various types of IEM may be affected. Relevant translational research and clinical experience will be reviewed with practical management aspects cited. Based on current literature, the impact of maternal IEM on mother and/or foetus, as well as how foetal IEM may affect the mother, will be considered. Insights gained from these rare disorders to more common conditions will be explored. Gaps in the literature, unanswered questions and steps to enhance further knowledge and systematically capture experience, such as establishment of an IEM-pregnancy registry, will be summarized.

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Lysine Requirements of Healthy Pregnant Women are Higher During Late Stages of Gestation Compared to Early Gestation

Abstract: Background: Lysine is the first limiting amino acid in cereal proteins and is found mainly in animal-derived products.

Cited by 27 publications

References 38 publications

Maternal Serum Albumin Redox State Is Associated with Infant Birth Weight in Japanese Pregnant Women

Maternal Serum Albumin Redox State Is Associated with Infant Birth Weight in Japanese Pregnant Women

Improved taste and texture in novel popcorn varieties compared to conventional lines

Impact of pregnancy on inborn errors of metabolism

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