Protein Metabolism in Cornea from Hypophysectomized Rats

Abstract

Hypophysectornized Rats. Tohoku J. exp. Med., 1970, 101 (2), 141-145-The effects of hypophysectomy and of growth hormone administration on in vitro incorporation of 14C-labeled leucine into protein of isolated rat cornea were studied.

Corneal biomechanical properties of patients with acromegaly

“…In the current study, as the CCT values were similar in acromegaly and control groups, higher CH and CRF values in the acromegaly group were possibly related to structural changes in the cornea due to hormonal factors. Growth hormone deprivation by hypophysectomy in rats reported to be diminishing the amino acid pool of the cornea, and the diminution could be counteracted by the administration of growth hormone 5. Hypersecretion of growth hormone and IGF-1 are hallmarks of acromegaly 22.…”

Effect of Malnutrition on Cortisol-Binding Protein in the Lens of Cynomolgus Monkeys

“…Deficiency of riboflavin, folic acid and vitamin E sometimes cause opacity in the lens of experimental animals (14-16). We have demonstrated that feeding on an excess glucose diet for a long period of time depresses the incorporation of 14C-leucine into the protein-fraction of rat lens (17).…”