Physiological Chemistry of the Eye

Gw, Barber

doi:10.1001/archopht.1973.01000040238016

Cited by 7 publications

(2 citation statements)

References 565 publications

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“…Though there are many risk factors identified for cataract genesis, the exact pathogenesis is not yet established. 1 Lens in its anatomical site remains in constant contact with aqueous humour. It is a clear fluid, an ultrafiltration of serum acts as an analogue of the blood.…”

Section: Introductionmentioning

confidence: 99%

Serum electrolytes in cataract patients with and without diabetes: A case control study

Soujanya¹,

Inchara²,

Kanthamani³

2019

IJCEO

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Introduction: Cataract is the cloudiness of the lens causing dispersion of light so as to cause significant optical disturbance. Cataract development occurs more frequently and at a younger age in diabetics compared to nondiabetic patients. Aqueous acts as an ocular lymph which is analogous to serum. So any dyselectrolemia which is common in diabetics can cause water and cationic imbalance in the lens resulting in cataract formation. Materials and Methods: This case-control study was done with 75 diabetic and 75 nondiabetic cataract subjects, by comparing the serum electrolytes of both the groups. Statistical analysis was done using SPSS version 21. Student's unpaired't' test was used to compare the means of electrolytes. Regression analysis and Odd's ratio was calculated to study the association between electrolytes and the risk of cataractogenesis. Result: Significant rise in serum Na+, K+ and Cl-levels (p<0.0001, <0.0286, <0.0001 respectively) were observed in diabetics compared to nondiabetic cataracts. This rise in electrolytes will pose 1.4, 1.8, 1.17 times (Na+, K+ and Cl-respectively) higher odds of early formation of cataract in diabetics compared to nondiabetics. Conclusion:This study concludes and validates the increased risk of cataractogenesis in diabetics when compared to non-diabetics as shown by other studies. Also reflected the significant difference in the serum electrolytes in comparison with the non-diabetics. Thus indicating the dietary restriction of salt in diabetics which hasten the onset and progression of cataract.

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Section: Introductionmentioning

confidence: 99%

Serum electrolytes in cataract patients with and without diabetes: A case control study

Soujanya¹,

Inchara²,

Kanthamani³

2019

IJCEO

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“…Increased membrane permeability and accumulation of sodium have been impli cated in many experimental cataracts [Barber, 1973] and in human cataracts [van Heyningen, 1972J. We have obtained data on the efficiency of the cation pump and the permeability of the lens membranes to sodium in early stages of human cataractous lenses and during the development of allo xan-induced diabetic cataract in rats.…”

Section: Introductionmentioning

confidence: 99%

Studies on Cataractogenesis in Humans and in Rats with Alloxan-Induced Diabetes

et al. 1985

Ophthalmic Res

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Changes in the cation balance cause hydration and initiate the process of lens opacification. Such alterations were studied in human cataractous lenses and during the development of alloxan-induced diabetic cataract in rats by biochemical and histochemical techniques. The development of alloxan-induced cataract in rats was examined in vivo which showed cortical opacities beginning after 32 days. These opacities did progress to maturity after 64 days and finally the lenses were completely opacified after 96 days of alloxan treatment. The histochemical localization of sodium-potassium-activated adenosine triphosphatase using three different methods provided information on the possible role of this enzyme in normal and cataractous lenses. In human cataractous lenses, sodium-potassium adenosine triphosphatase activity was found to be considerably decreased, whereas no activity of this enzyme was localized in human diabetic cataractous lenses. An animal model provided evidence that an apparent decrease of sodium-potassium adenosine triphosphatase may be involved in the initiation of alloxan-induced diabetic cataract in rats.

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Free Amino Acids and other Solutes in the Lens during Formation and Reversal of Triparanol Cataracts

Barber

Goodwin

1979

Progress in Anterior Eye Segment Research and Practice

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Physiological Chemistry of the Eye

Cited by 7 publications

References 565 publications

Serum electrolytes in cataract patients with and without diabetes: A case control study

Serum electrolytes in cataract patients with and without diabetes: A case control study

Studies on Cataractogenesis in Humans and in Rats with Alloxan-Induced Diabetes

Free Amino Acids and other Solutes in the Lens during Formation and Reversal of Triparanol Cataracts

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