Hypophysectornized Rats. Tohoku J. exp. Med., 1970, 101 (2), 141-145-The effects of hypophysectomy and of growth hormone administration on in vitro incorporation of 14C-labeled leucine into protein of isolated rat cornea were studied.
The distribution rate of sodium iodide (Na131I) and toxohormone labeled with Na131I in rats under various experimental conditions was described. Toxohormone extracted from the cancer tissue of the stomach removed by surgical operation exhibited a remarkable inhibitory effect on liver catalase. Compared with the distribution of Na131I in the liver and spleen of the normal rats, that of Na131I labeled toxohormone in the above organs was found to be characteristically decreased. It was also decreased in the liver of splenectomized rats. The distribution of Na131I was reduced in the liver and spleen of rats, which had been treated with toxohormone for successive two days. It was also decreased in the above organs of rats with moderate liver impairment.
BACKGROUND AND PURPOSE:The signal intensity of the thyroid in neonates is high on T1WI. It is affected by gestational and postnatal ages. However, the extent of the influence of these ages is unknown. This study investigated the relationship of signal intensities of the infant thyroid with postnatal and gestational ages and anterior pituitary using 3D gradient-echo T1WI.
MATERIALS AND METHODS:This retrospective study included 183 T1-weighted images from 181 infants. Using a multiple linear regression analysis, we evaluated the effects of postnatal and gestational ages on the thyroid-muscle signal intensity ratio. The relationship between the thyroid and anterior pituitary signal intensities on T1WI and the age of the infants was evaluated.RESULTS: Multiple linear regression analysis showed that the thyroid signal intensity was affected negatively by postnatal age at examination and positively by gestational age at birth (P , .01 and P ¼ .04, respectively). According to the standardized partial regression coefficients, the influence of postnatal age at examination was stronger than that of gestational age at birth (À0.72 and 0.13, respectively). The thyroid and anterior pituitary signal intensities reached constant values at 12 weeks' postnatal age, and the mean thyroid-anterior pituitary signal intensity ratios were almost 1 throughout the entire period.
CONCLUSIONS:The signal intensity of the infant thyroid on T1WI was more strongly influenced by the postnatal age at examination than the gestational age at birth, and it was almost equal to that of the anterior pituitary.
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