Study on the Distribution of ¹³¹I Labeled Toxohormone

Abstract

The distribution rate of sodium iodide (Na131I) and toxohormone labeled with Na131I in rats under various experimental conditions was described. Toxohormone extracted from the cancer tissue of the stomach removed by surgical operation exhibited a remarkable inhibitory effect on liver catalase. Compared with the distribution of Na131I in the liver and spleen of the normal rats, that of Na131I labeled toxohormone in the above organs was found to be characteristically decreased. It was also decreased in the liver of splenectomized rats. The distribution of Na131I was reduced in the liver and spleen of rats, which had been treated with toxohormone for successive two days. It was also decreased in the above organs of rats with moderate liver impairment.