Protein carbonylation is a mediator in larvicidal mechanisms of Tabernaemontana cymosa ethanolic extract

Rodríguez-Cavallo, Erika; Guarnizo-Méndez, Javier; Yépez-Terrill, Adriana; Cárdenas-Rivero, Aury; Díaz-Castillo, Fredyc; Méndez-Cuadro, Darío

doi:10.1016/j.jksus.2018.04.019

Cited by 12 publications

(7 citation statements)

References 23 publications

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“…In this season, the GST levels were also high, leading us to conclude that the increase in salinity and element bioaccumulation might have contributed to the production of ROS, which induced protein damage. This phenomenon could lead to irreversible damage and possible cellular death [ 93 , 94 ].…”

Section: Discussionmentioning

confidence: 99%

Interplay of Seasonality, Major and Trace Elements: Impacts on the Polychaete Diopatra neapolitana

Giménez

Cardoso

Sá

et al. 2022

Biology

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Polychaetes are known to be good bioindicators of marine pollution, such as inorganic contamination. Major and trace elements are commonly present in sediment and may be accumulated by polychaetes such as the tubiculous Diopatra neapolitana. In this study, D. neapolitana individuals were collected in the autumn, winter, spring, and summer of 2018/2019 from the Ria de Aveiro lagoon (western Portugal) to understand how seasonality influences element accumulation. The impact of the interaction of seasonality and elements on oxidative status, energy metabolism, and oxidative damage was also assessed. The obtained results showed that the activity of the antioxidant enzymes catalase, glutathione S-transferases, and non-protein thiol levels were higher in summer and that superoxide dismutase, lipid peroxidation, and electron transport system activity increased in winter. The lowest glycogen levels were observed during spring, and protein carbonylation was the highest during autumn. These results could mainly be related to high temperatures and the bioaccumulation of Al, As, Mn, and Zn. Energy-related parameters increased during spring and autumn, mainly due to the bioaccumulation of the same elements during spring and summer. Lipid damage was higher during winter, which was mainly due to salinity and temperature decreases. Overall, this study demonstrates that seasonality plays a role in element accumulation by polychaetes and that both impact the oxidative status of D. neapolitana.

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Section: Discussionmentioning

confidence: 99%

Interplay of Seasonality, Major and Trace Elements: Impacts on the Polychaete Diopatra neapolitana

Giménez

Cardoso

Sá

et al. 2022

Biology

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“…aegypti proved that rotational insecticide with different modes of action and target sites is necessary done. Temephos is a compound that plays a role in protein carbonylation so that it causes the general oxidative damage in larval cellular of insects ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Larvicidal Activity of Ethyl Acetate Extract of Derris elliptica Root against the Third-instar Larvae of Cypermethrin-Resistant Aedes aegypti Offspring

Sayono

Anwar

Sumanto

2021

JAD

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Background: Derris elliptica extracts have a high larvicidal potential against the laboratory strain of Aedes aegypti larvae, but the effect on offspring larvae of pyrethroid-resistant strains of the species is lack understood. This study aimed to determine the larvicidal activity of the ethyl acetate extract of tuba root against the third-instar larvae of the Cypermethrin-resistant Ae. aegypti offspring. Methods: The experimental study occupied four levels of ethyl acetate extract of D. elliptica namely 10, 25, 50, and 100 ppm, and each level was four times replicated. As many as twenty of healthy third-instar larvae, offspring of Cypermethrin-resistant Ae. aegypti were subjected to each experiment group. Larval mortality rate and lethal concentration 50% subject (LC50) were calculated after 24 and 48 hours of exposure time. Results: Mortality of larvae increased directly proportional to the increase of extract concentration. Larval mortality rates after 24 and 48 hours of exposure were 40–67.5% and 62.5–97.5%, and LC50 were 34.945 and 6.461ppm, respectively. Conclusion: The ethyl acetate extract of D. elliptica has the high effectiveness larvicidal potential against the thirdinstar larvae, offspring of the Cypermethrin-resistant Ae. aegypti. Isolation of the specific compound is necessarily done to obtain the active ingredient for larvicide formulation.

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“…The mechanism of action of natural products on Aedes spp. larvae has been investigated in recent studies [1,37]. Among the explanations of this mechanism are the ultrastructural alterations of organs such as anal papillae [38], intestinal and tracheal system damage [1], inhibition of enzymatic activity [39], and morphological aberrations [40].…”

Section: Resultsmentioning

confidence: 99%

Larvicidal and Enzymatic Inhibition Effects of Annona muricata Seed Extract and Main Constituent Annonacin against Aedes aegypti and Aedes albopictus (Diptera: Culicidae)

et al. 2019

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The mosquitoes Aedes aegypti and Aedes albopictus are vectors of arboviruses that cause dengue, zika and chikungunya. Bioactive compounds from plants are environmentally sustainable alternatives to control these vectors and thus the arboviruses transmitted by them. The present study evaluated the larvicidal activity of an acetogenin-rich fraction (ACERF) and its main constituent annonacin obtained from Annona muricata seeds on Ae. aegypti and Ae. albopictus. The larvicidal assays were performed using different concentrations to calculate the LC50 and LC90 values observed 24 h after exposure to the treatment. Annonacin was more active against Ae. aegypti (LC50 2.65 μg·mL−1) in comparison with Ae. albopictus (LC50 8.34 μg·mL−1). In contrast, the acetogenin-rich fraction was more active against Ae. albopictus (LC50 3.41 μg·mL−1) than Ae. aegypti (LC50 12.41 μg·mL−1). ACERF and annonacin treated larvae of Ae. aegypti and Ae. albopictus showed significant differences in the inhibition of their metabolic enzymes when compared to untreated larvae. The results demonstrate the relevant larvicidal action of the acetogenin-rich fraction and annonacin showing the potential to develop new products for the control of Ae. aegypti and Ae. albopictus.

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Protein carbonylation is a mediator in larvicidal mechanisms of Tabernaemontana cymosa ethanolic extract

Cited by 12 publications

References 23 publications

Interplay of Seasonality, Major and Trace Elements: Impacts on the Polychaete Diopatra neapolitana

Interplay of Seasonality, Major and Trace Elements: Impacts on the Polychaete Diopatra neapolitana

Larvicidal Activity of Ethyl Acetate Extract of Derris elliptica Root against the Third-instar Larvae of Cypermethrin-Resistant Aedes aegypti Offspring

Larvicidal and Enzymatic Inhibition Effects of Annona muricata Seed Extract and Main Constituent Annonacin against Aedes aegypti and Aedes albopictus (Diptera: Culicidae)

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