Protective effects of Coridius chinensis extracts on rat reproductive damage induced by manganese

Abstract

Manganese (Mn 2+ ) is found in very small amounts in the body, but it plays an important role in maintaining normal physiological condition and involves in many cellular biological processes. It also involves the composition of many enzymes and affects the enzyme activity. It is also required for other aspects, such as blood glucose regulation, development of bone and reproduction, and brain (Aschner & Aschner, 2005;Greger, 1999). Although an adequate intake of Mn 2+ is necessary for the human body, the excessive Mn 2+ exposure can lead to male fertility decline. Numerous studies proved that environmental toxicants, manganese (Mohammed et al., 2018;

Modern pharmacological research and application of medicinal insect Coridius chinensis

“…The Great Dictionary of traditional Chinese Medicine states that Coridius chinensis has a notable effect on conditions such as sore and weak waist, impotence, and enuresis, which are caused by yang deficiency in the spleen and kidney [ 1 ]. Numerous studies have demonstrated that extracts and small molecular compounds derived from Coridius chinensis can enhance reproductive ability and safeguard against reproductive damage [ 18 , [33] , [34] , [35] , [42] , [43] , [44] ]. It has been reported that the alcohol extract of Coridius chinensis can enhance exercise ability and increase the activity of antioxidant enzymes in the skeletal muscle of trained rats [ 36 , 45 ].…”

“…Moreover, petroleum ether extract from Coridius chinensis is capable of significantly inhibiting Mn 2+ -induced blood-testicular barrier (BTB) damage. Additionally, the water extract of Coridius chinensis can augment testosterone production in Leydig cells and regulate the hypothalamus-pituitary-testis axis to preserve the structure and function of the testis [ [32] , [33] , [34] ]. Furthermore, studies have shown that (±) AspongamideA isolated from Coridius chinensis possesses a certain protective effect against diabetic nephropathy and can inhibit the activity of COX-2 [ 10 ].…”