Modern pharmacological research and application of medicinal insect Coridius chinensis

Xiong, Keyi; Zeng, Fengyin; Lei, Xuanqin; Wei, Yongqiu; Zhou, Xin; Hou, Xiaohui

doi:10.1016/j.heliyon.2024.e24613

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Drugs such as turgeon and salvia miltiorrhiza have the effect of removing blood stasis, which can improve hemodynamics and promote absorption of local inflammation[ 7 ]. Nine fragrant worms have anticancer functions[ 8 ]. In view of the pharmacological mechanism of Tongluo Jiedu prescription, patients with oral cancer in our hospital were prospectively selected to receive continuous arterial perfusion chemotherapy assisted by Tongluo Jiedu prescription after surgery to observe the effects on immune function and oxidative stress response.…”

Section: Discussionmentioning

confidence: 99%

Effects of Tongluo Jiedu prescription on immune function and oxidative stress in patients with oral cancer

Yin,

Yao,

et al. 2024

World J Clin Cases

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BACKGROUND Oral cancer, which is caused by mucous membrane variation, represents a prevalent malignant tumor in the oral and maxillofacial region, posing a significant threat to patients’ lives and safety. While surgical intervention stands as a cornerstone treatment for oral cancer patients, it carries the risk of incomplete treatment or high rates of postoperative recurrence. Hence, a multifaceted approach incorporating diverse treatment modalities is essential to enhance patient prognosis. AIM To analyze the application effect of Tongluo Jiedu prescription as adjuvant therapy and its influence on patient prognosis in patients with oral cancer. METHODS Eighty oral cancer patients in our hospital were selected and divided into the observation group and control group by a random number table. The control group was treated with continuous arterial infusion chemotherapy of cisplatin and 5-fluorouracil. The observation group was additionally given Tongluo Jiadu prescription. The inflammatory stress level, peripheral blood T-cell subsets, and immune function of the two groups were subsequently observed. SPSS 21.0 was used for data analysis. RESULTS The observation group demonstrated lower levels of interleukin-6 and C-reactive protein, and a higher level of tumor necrosis factor in comparison to the control group. After treatment, the immune function in the observation group was significantly better than in the control group. CONCLUSION Tongluo Jiedu prescription can improve the immune function and oxidative stress level of patients with oral cancer and accelerate the recovery process.

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Section: Discussionmentioning

confidence: 99%

Effects of Tongluo Jiedu prescription on immune function and oxidative stress in patients with oral cancer

Yin,

Yao,

et al. 2024

World J Clin Cases

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show abstract

“…This insect has several anticancer qualities and is often found in China and Southeast Asia [ 2 ]. In earlier studies, evidence has been presented to support several health advantages associated with the use of this insect, particularly in relation to its anti-cancer, anti-bacterial, and anti-clotting properties [ [3] , [4] , [5] , [6] ]. Thus, its diverse properties highlight the crucial role of this valuable insect as a cultural, medicinal, and economic resource.…”

Section: Introductionmentioning

confidence: 99%

Aspongopus chinensis Dallas induces pro-apoptotic and cell cycle arresting effects in hepatocellular carcinoma cells by modulating miRNA and mRNA expression

Cai,

Chen,

Khan

et al. 2024

Heliyon

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Network pharmacology combined with molecular docking revealed the potential targets of Coridius chinensis in prostate cancer treatment

Zhang,

Ma,

Zeng

et al. 2024

World J Clin Cases

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BACKGROUND Prostate cancer (PCa) has high morbidity and mortality rates in elderly men. With a history of thousands of years, traditional Chinese medicine derived from insects could be an important source for developing cancer-targeted drugs to prevent tumorigenesis, enhance therapeutic effects, and reduce the risk of recurrence and metastasis. Multiple studies have shown that Coridius chinensis (Cc) has anticancer effects. AIM To elucidate the mechanism of action of Cc against PCa via network pharmacology and molecular docking. METHODS Potential targets for Cc and PCa were predicted using ChemDraw 19.0 software, the PharmMapper database and the GeneCards database. Then, the STRING database was used to construct the protein–protein interaction network. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment and molecular docking analyses were subsequently conducted to identify the key targets, active ingredients and pathways involved. RESULTS GO and KEGG analyses indicated that the PI3K-Akt signalling pathway was the critical pathway (P value < 1.0 × 10-8). Multiple targeting ingredients that can affect multiple pathways in PCa have been identified in Cc. Seven active compounds (asponguanosines A, asponguanine B, asponguanine C, aspongpyrazine A, N-acetyldopamine, aspongadenine B and aspongpyrazine B) were selected for molecular docking with 9 potential targets, and the results revealed that aspongpyrazine A and asponguanosine A are the main components by which Cc affects PCa (affinity<-5 kcal/mol, hydrogen bonding), but more studies are needed. CONCLUSION We used network pharmacology to predict the bioactive components and important targets of Cc for the treatment of PCa, supporting the development of Cc as a natural anticancer agent.

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Modern pharmacological research and application of medicinal insect Coridius chinensis

Cited by 3 publications

References 15 publications

Effects of Tongluo Jiedu prescription on immune function and oxidative stress in patients with oral cancer

Effects of Tongluo Jiedu prescription on immune function and oxidative stress in patients with oral cancer

Aspongopus chinensis Dallas induces pro-apoptotic and cell cycle arresting effects in hepatocellular carcinoma cells by modulating miRNA and mRNA expression

Network pharmacology combined with molecular docking revealed the potential targets of Coridius chinensis in prostate cancer treatment

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