Aspongopus chinensis Dallas induces pro-apoptotic and cell cycle arresting effects in hepatocellular carcinoma cells by modulating miRNA and mRNA expression

Cai, Renlian; Chen, Xumei; Khan, Samiullah; Li, Haiyin; Tan, Jun; Tian, Ying; Zhao, Shuai; Yin, Zhiyong; Jin, Daochao; Guo, Jianjun

doi:10.1016/j.heliyon.2024.e27525

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e27525

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Aspongopus chinensis Dallas induces pro-apoptotic and cell cycle arresting effects in hepatocellular carcinoma cells by modulating miRNA and mRNA expression

Renlian Cai,

Xumei Chen,

Samiullah Khan

et al.

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2024

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Network pharmacology combined with molecular docking revealed the potential targets of Coridius chinensis in prostate cancer treatment

Zhang,

Ma,

Zeng

et al. 2024

World J Clin Cases

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BACKGROUND Prostate cancer (PCa) has high morbidity and mortality rates in elderly men. With a history of thousands of years, traditional Chinese medicine derived from insects could be an important source for developing cancer-targeted drugs to prevent tumorigenesis, enhance therapeutic effects, and reduce the risk of recurrence and metastasis. Multiple studies have shown that Coridius chinensis (Cc) has anticancer effects. AIM To elucidate the mechanism of action of Cc against PCa via network pharmacology and molecular docking. METHODS Potential targets for Cc and PCa were predicted using ChemDraw 19.0 software, the PharmMapper database and the GeneCards database. Then, the STRING database was used to construct the protein–protein interaction network. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment and molecular docking analyses were subsequently conducted to identify the key targets, active ingredients and pathways involved. RESULTS GO and KEGG analyses indicated that the PI3K-Akt signalling pathway was the critical pathway (P value < 1.0 × 10-8). Multiple targeting ingredients that can affect multiple pathways in PCa have been identified in Cc. Seven active compounds (asponguanosines A, asponguanine B, asponguanine C, aspongpyrazine A, N-acetyldopamine, aspongadenine B and aspongpyrazine B) were selected for molecular docking with 9 potential targets, and the results revealed that aspongpyrazine A and asponguanosine A are the main components by which Cc affects PCa (affinity<-5 kcal/mol, hydrogen bonding), but more studies are needed. CONCLUSION We used network pharmacology to predict the bioactive components and important targets of Cc for the treatment of PCa, supporting the development of Cc as a natural anticancer agent.

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Network pharmacology combined with molecular docking revealed the potential targets of Coridius chinensis in prostate cancer treatment

Zhang,

Ma,

Zeng

et al. 2024

World J Clin Cases

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Aspongopus chinensis Dallas induces pro-apoptotic and cell cycle arresting effects in hepatocellular carcinoma cells by modulating miRNA and mRNA expression

Cited by 1 publication

References 55 publications

Network pharmacology combined with molecular docking revealed the potential targets of Coridius chinensis in prostate cancer treatment

Network pharmacology combined with molecular docking revealed the potential targets of Coridius chinensis in prostate cancer treatment

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