Protective effects of HN and F glycoprotein‐specific monoclonal antibodies on experimental newcastle disease

Protective effects of monoclonal antibodies against lethal canine distemper virus infection in mice

“…In general, antibodies against H or haemagglutinin-neuraminidase of paramyxoviruses have neutralizing activity and inhibit virus attachment, and antibodies against F prevent the spread of infection. The protective effects of anti-F antibodies are particularly important in some paramyxoviruses (L6ve et al, 1986;Meulemans et al, 1986;Orvell & Grandien, 1982;Rydbeck etal., 1988). In dogs, immunity to F restricts the spread of CDV infection more efficiently than immunity to H .…”

“…For example, the protective effect of MAbs against the F of Newcastle disease virus (Meulemans et al, 1986), Sendai virus (Orvell & Grandien, 1982) and parainfluenza virus type 3 (Rydbeck et al, 1988) has been shown to be produced by neutralizing activity whereas the protective activity of non-neutralizing MAbs against the F of mumps virus was considered to be relevant to CDC or ADCC (L6ve et al, 1986). In the present study, only MAbs which protected mice had FI activity, whereas complement-dependent neutralizing activity, ADCC and CDC were found for all MAbs regardless of protective capacity.…”

Protective Effect of MonoclonalAntibodies to Newcastle Disease Virus in Passive Immunization

“…mumps virus (Wolinsky et al, 1985;L6ve et al, 1986), parainfluenza virus type 3 (Rydbeck et al, 1988), respiratory syncytial virus (Taylor et al, 1984), measles virus (Rammohan et al, 1981 ;Giraudon & Wild, 1985;Varsanyi et al, 1987), Sendai virus (Orvell et al, 1982) and NDV (Meulemans et al, 1986;Lana et al, 1988). It is generally agreed that anti-HN MAbs with neutralizing activity have a protective effect upon virus infection.…”

Chitosan-coated poly(lactic-co-glycolic) acid nanoparticles as an efficient delivery system for Newcastle disease virus DNA vaccine

“…In many countries, ND is a catastrophic problem for the poultry industry. 1 Although the disease is difficult to control, vaccines are available. The efficacy of NDV vaccines depends on the induction of F glycoproteins.…”