Protective effect of TiO2 nanowhiskers on Tetra Sulphonatophenyl Porphyrin (TSPP) complexes induced oxidative stress during photodynamic therapy

Rehman, Fawad Ur; Zhao, Chunqiu; Jiang, Hui; Selke, Matthias; Wang, Xuemei

doi:10.1016/j.pdpdt.2015.08.005

Cited by 24 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This question cannot be unambiguously answered because further research is needed in the coming years. Nevertheless, some studies, like that performed by Rehman et al can be considered at a very initial stage as promising [24]. The authors assessed the importance of TiO 2 nanowhiskers in combination with 5,10,15,20-tetra(4-sulfonatophenyl)porphyrin (TSPP) in vivo on rats.…”

Section: Toxicity and Biocompatibility-in Vitro And In Vivo Evaluatiomentioning

confidence: 99%

“…According to the MTT assay, TSPP combined with TiO 2 nanowhiskers revealed minimized cytotoxic effects on the normal cells in terms of increased viability. This protection of the TiO 2 nanowhiskers was attributed to their porous nature allowing a slow release of the adsorbed TSPP into the surrounding environment, thus helping in lowering adverse effects without compromising the theranostic properties [24].…”

Section: Toxicity and Biocompatibility-in Vitro And In Vivo Evaluatiomentioning

confidence: 99%

See 1 more Smart Citation

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

et al. 2020

View full text Add to dashboard Cite

Metallic and metal oxide nanoparticles (NPs), including titanium dioxide NPs, among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO2) is an inorganic compound that owes its recent rise in scientific interest to photoactivity. After the illumination in aqueous media with UV light, TiO2 produces an array of reactive oxygen species (ROS). The capability to produce ROS and thus induce cell death has found application in the photodynamic therapy (PDT) for the treatment of a wide range of maladies, from psoriasis to cancer. Titanium dioxide NPs were studied as photosensitizing agents in the treatment of malignant tumors as well as in photodynamic inactivation of antibiotic-resistant bacteria. Both TiO2 NPs themselves, as well as their composites and combinations with other molecules or biomolecules, can be successfully used as photosensitizers in PDT. Moreover, various organic compounds can be grafted on TiO2 nanoparticles, leading to hybrid materials. These nanostructures can reveal increased light absorption, allowing their further use in targeted therapy in medicine. In order to improve efficient anticancer and antimicrobial therapies, many approaches utilizing titanium dioxide were tested. Results of selected studies presenting the scope of potential uses are discussed in this review.

show abstract

Section: Toxicity and Biocompatibility-in Vitro And In Vivo Evaluatiomentioning

confidence: 99%

Section: Toxicity and Biocompatibility-in Vitro And In Vivo Evaluatiomentioning

confidence: 99%

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[58] Urea, uric acid, and creatinine are reliable biomarkers of renal toxicity. Levels of lysosomal enzymes, alanine aminotransferases (ALT), and aspartate aminotransferase (AST) are increased significantly in a toxic environment because of tissues damage in liver and kidney.…”

Section: Biochemical Analysismentioning

confidence: 99%

Hydroxypropyl‐β‐cyclodextrin hybrid nanogels as nano‐drug delivery carriers to enhance the solubility of dexibuprofen: Characterization, in vitro release, and acute oral toxicity studies

2017

View full text Add to dashboard Cite

The purpose of this study was to develop and characterize hydroxypropyl-βcyclodextrin (HPβCD) hybrid nanogels for solubility enhancement of lipophilic drug, dexibuprofen. HPβCD hybrid nanogels were designed by chemical crosslinking of hydroxypropyl-β-cyclodextrin with 2-acrylamido-2-methyl propane sulfonic acid (AMPS) via free radical polymerization. Loading efficiency, solubilization, zetasizer, FESEM Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), powder X-ray diffraction (PXRD), and in vitro drug release analysis were performed for characterization of hybrid nanogels. Efficient solubilization of dexibuprofen has been observed by HPβCD hybrid nanogels. FTIR, TGA, and DSC studies confirmed the formation of new hybrid nanogels and complexation of dexibuprofen with nanogels. XRD analysis revealed loss of dexibuprofen crystallinity in hybrid nanogels. Highly porous and amorphous nanogels showed a significant dexibuprofen release in aqueous medium. In toxicity studies, no significant changes in behavioral, physiological, biochemical, or histopathological parameters of animals endorsed that developed formulations are nontoxic and biocompatible. K E Y W O R D Samorphous, differential scanning calorimetry, drug delivery systems, Fourier transform infrared, hostguest systems, hybrid nanogels, hydroxypropyl-β-cyclodextrin, nanotechnology, radical polymerization, thermal gravimetric analysis, toxicity studies

show abstract

“…This question cannot be unambiguously answered because further research is needed in the coming years. Nevertheless, some studies, like that performed by Rehman et al can be considered at a very initial stage as promising [24]. The authors assessed the importance of TiO2 nanowhiskers in combination with 5,10,15,20-tetra(4-sulfonatophenyl)porphyrin (TeSPP) in vivo on rats.…”

Section: Toxicity and Biocompatibility -In Vitro And In Vivo Evaluatimentioning

confidence: 99%

“…According to MTT assay, TeSPP combined with TiO2 nanowhiskers revealed minimized cytotoxic effects on the normal cells in terms of increased viability. This protection of the TiO2 nanowhiskers was attributed to their porous nature allowing a slow release of the adsorbed TeSPP into the surrounding environment, thus helping in lowering adverse effects without compromising the theranostic properties [24].…”

Section: Toxicity and Biocompatibility -In Vitro And In Vivo Evaluatimentioning

confidence: 99%

Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

Mlynarczyk

et al. 2020

Preprint

101

View full text Add to dashboard Cite

Metallic nanoparticles (NPs), among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in the novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO2) is an inorganic compound that owes its recent rise in scientific interest to photoactivity. After the illumination in aqueous media with UV light, TiO2 produces an array of reactive oxygen species (ROS). The capability to produce ROS and thus induce cell death has found application in the photodynamic therapy (PDT) for the treatment of a wide range of maladies, from psoriasis to cancer. Titanium dioxide NPs were studied as photosensitizing agents in the treatment of malignant tumors as well as in photodynamic inactivation of antibiotic-resistant bacteria. Both TiO2 NPs themselves, as well as their composites with other molecules, can be successfully used as photosensitizers in PDT. Moreover, various organic compounds can be grafted on TiO2 NPs, leading to hybrid materials. These nanostructures can reveal increased light absorption allowing their further use in targeted therapy in medicine. In order to improve efficient anticancer therapy, many approaches utilizing titanium dioxide were tested. The most significant studies are discussed in this review.

show abstract

Protective effect of TiO2 nanowhiskers on Tetra Sulphonatophenyl Porphyrin (TSPP) complexes induced oxidative stress during photodynamic therapy

Abstract: It was evident that increase in concentration of TSPP increased the toxic effects; however, the TiO2 nanowhiskers combination with TSPP decreased these adverse effects. Moreover, TSPP (0.1 mM) combined with TiO2 nanowhiskers (0.6 mM) was safer than TSPP (0.1 mM) alone.

Cited by 24 publications

References 33 publications

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Hydroxypropyl‐β‐cyclodextrin hybrid nanogels as nano‐drug delivery carriers to enhance the solubility of dexibuprofen: Characterization, in vitro release, and acute oral toxicity studies

Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine

Contact Info

Product

Resources

About

Protective effect of TiO2 nanowhiskers on Tetra Sulphonatophenyl Porphyrin (TSPP) complexes induced oxidative stress during photodynamic therapy

Abstract: It was evident that increase in concentration of TSPP increased the toxic effects; however, the TiO2 nanowhiskers combination with TSPP decreased these adverse effects. Moreover, TSPP (0.1 mM) combined with TiO2 nanowhiskers (0.6 mM) was safer than TSPP (0.1 mM) alone.

Cited by 24 publications

References 33 publications

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Hydroxypropyl‐β‐cyclodextrin hybrid nanogels as nano‐drug delivery carriers to enhance the solubility of dexibuprofen: Characterization, in vitro release, and acute oral toxicity studies

Titanium Dioxide Nanoparticles &ndash; Prospects and Applications in Medicine

Contact Info

Product

Resources

About

Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine