Titanium Dioxide Nanoparticles &amp;ndash; Prospects and Applications in Medicine

Ziental, Daniel; Czarczyńska-Goślińska, Beata; Mlynarczyk, Dariusz T.; Glowacka-Sobotta, Arleta; Stanisz, Beata; Gośliński, Tomasz; Sobotta, Łukasz

doi:10.20944/preprints202002.0271.v1

Cited by 102 publications

(3 citation statements)

References 103 publications

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“…Titanium dioxide nanoparticles (TiO 2 NPs) have a variety of applications, from use in sunscreens, toners, and cosmetics to photodynamic therapy and treatment of waste water [1][2][3][4]. There are a variety of methods used to synthesize TiO 2 NPs, resulting in the different particle properties that give TiO 2 NPs their wide range of applications [1,5,6].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

Yamano

Goto

Takeda

et al. 2022

Preprint

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Background: Most toxicological studies on titanium dioxide (TiO2) particles to date have concentrated on carcinogenicity and acute toxicity, with few studies focusing of pneumoconiosis, which is a variety of airspace and interstitial lung diseases caused by particle-laden macrophages. The present study examined rat pulmonary lesions associated with pneumoconiosis after inhalation exposure to TiO2 nanoparticles (NPs). Methods: Male and female F344 rats were exposed to 6.3, 12.5, 25, or 50 mg/m3 anatase type TiO2 NPs for 6 hours/day, 5 days/week for 13 weeks using a whole-body inhalation exposure system. After the last exposure the rats were euthanized and blood, bronchoalveolar lavage fluid, and all tissues including lungs and mediastinal lymph nodes were collected and subjected to biological and histopathological analyses. Results: Numerous milky white spots were present in the lungs after exposure 25 and 50 mg/m3 TiO2 NPs. Histopathological analysis revealed that the spots were alveolar lesions, characterized predominantly by the agglomeration of particle-laden macrophages and the presence of reactive alveolar epithelial type 2 cell (AEC2) hyperplasia. We defined this characteristic lesion as pulmonary dust foci (PDF). The PDF is an inflammatory niche, with decreased vascular endothelial cells in the interstitium, and proliferating AEC2 transformed into alveolar epithelial progenitor cells. The AEC2 in the PDF had acquired DNA damage. Based on PDF induction, the lowest observed adverse effect concentration for pulmonary disorders in male and female rats in this study was 12.5 mg/m3 and 6.3 mg/m3, respectively. The no observed adverse effect concentration for male rats was 6.3 mg/m3. There was a sex difference in lung lesion development, with females showing more pronounced lesion parameters than males. Conclusions: Inhalation exposure to TiO2 NPs caused PDF, an air-space lesion which is an alveolar inflammatory niche containing particle-laden macrophages and proliferating AEC2. This PDF histopathologically resembles some pneumoconiosis lesions (pulmonary siderosis and hard metal pneumoconiosis) in workers and lung disease in smokers, suggesting that it is an early pneumoconiosis lesion caused by exposure to TiO2 NPs in rats and a common alveolar reaction in mammals.

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Section: Introductionmentioning

confidence: 99%

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

Yamano

Goto

Takeda

et al. 2022

Preprint

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“…[76] Besides the sonocatalytic effects, pure TiO 2 has also been reported to generate cytotoxic ROS effectively with UV or visible light excitation. [77][78][79][80] However, the wide bandgap in TiO 2 nanomaterials distributing between 3.2 and 3.7 eV, thus irradiating only by UV light, which greatly hinders their application fields. [81] Changing the bandgap via modifying the structure of TiO 2 could improve the photocatalytic effects.…”

Section: Photoassisted Enzyme-mimic Catalysismentioning

confidence: 99%

ROS‐Catalytic Transition‐Metal‐Based Enzymatic Nanoagents for Tumor and Bacterial Eradication

Cao

Xiang

et al. 2021

Adv Funct Materials

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The extensive research into developing new nanomedicines during the past few years has witnessed significant progress in diverse biomedical fields, especially for combating drug resistance in antitumor and antibacterial therapies. Recently, transition-metal-based enzymatic nanoagents (TM-EnzNAs) with catalytic production of reactive oxygen species (ROS) have been designed and intensively explored, which have become powerful nanoplatforms and exciting research frontiers in constructing next-generation nanotherapeutics to combat drug-resistant tumors and bacteria. Here, the focus is on the recent design, fundamental principles, and material chemistries in developing and applications of TM-EnzNAs. At first, the different ROS-producing mechanisms and the key factors to enhance ROS level are carefully concluded, and the analytic methods are systematically summarized. Then, the rationally engineered TM-EnzNAs via different synthetic approaches with high ROS producing efficiencies are comprehensively discussed, especially the catalytic activities, mechanisms, and structure-function relationships. After that, the representative applications of these ROS-catalytic TM-EnzNAs for antitumor and bacterial eradication are summarized in detail. Finally, the primary challenges and future perspectives have also been outlined. It is anticipated new therapeutic insights into combating drug-resistant tumors and bacteria will be provided, and significant new inspiration for designing future enzymatic nanoagents is offered.

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“…Nanoporous materials are typically obtained via different methods including sol‐gel, hydrothermal, solvothermal, physical vapor deposition (PVD), chemical vapor deposition (CVD), electrochemical, and sonochemical methods [27,31–33] . Among these techniques, the hydrothermal technique has more advantages [34] .…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Synthesis Parameters of Nanoporous Titania Particles to Improve Structural Properties and Photocatalytic Activity

Hassankhani-Majd

Anbia

2021

ChemistrySelect

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Nanoporous materials have been widely used in many fields. However, their synthesis with uniform particle shapes, pore sizes, pore volumes, and surface areas remains a considerable challenge. Thus, choosing a suitable controllable method for synthesizing nanoporous materials is crucial to obtain appropriate properties. Herein, nanoporous titania particles (NPTPs) were prepared via the hydrothermal method. This study investigated how the synthesis parameters such as the type of chelating agent, the hydrolysis method, and the drying technique affected the properties of NPTPs. The NPTPs were characterized by XRD, FESEM, TEM, and BET. The results demonstrated that when acetylacetone (ACAC, as the chelating agent), the spray‐hydrolysis (SH) method, and the freeze‐drying (FD) technique were used, NPTPs achieved a more uniform particle shape, a smaller particle size, a larger pore size, a larger pore volume, and a higher surface area. Ultimately, the photocatalytic degradation (PCD) of methylene blue (MB) was examined using improved NPTPs.

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Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine

Cited by 102 publications

References 103 publications

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

ROS‐Catalytic Transition‐Metal‐Based Enzymatic Nanoagents for Tumor and Bacterial Eradication

Comparative Study of Synthesis Parameters of Nanoporous Titania Particles to Improve Structural Properties and Photocatalytic Activity

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