Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Ziental, Daniel; Czarczyńska-Goślińska, Beata; Mlynarczyk, Dariusz T.; Glowacka-Sobotta, Arleta; Stanisz, Beata; Gośliński, Tomasz; Sobotta, Łukasz

doi:10.3390/nano10020387

Cited by 422 publications

(275 citation statements)

References 114 publications

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“…On the other hand, in the balance of benefits versus toxicology of metal nanoparticles for the treatment of mellitus diabetes, different studies have described that metal nanoparticles (silver, gold, cooper, selenium, magnesium, cerium oxide, titanium dioxide [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ] and zinc oxide possess antihyperglycemic activity in diabetic rats after daily treatment for different periods [ 8 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats

et al. 2020

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Different studies in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) are useful as antidiabetic agents. However, this evidence was performed and measured in long-term treatments and with repeated doses of ZnONPs. This work aimed to evaluate the ZnONPs acute effects on glycemia during the next six h after an oral or intraperitoneal administration of the treatment in healthy and diabetic rats. In this study, the streptozotocin-nicotinamide intraperitoneal administration in male Wistar rats were used as a diabetes model. 10 mg/kg ZnONPs did not modify the baseline glucose in any group. Nevertheless, the ZnONPs short-term administration (100 mg/kg) induced a hyperglycemic response in a dose and route-dependent administration in healthy (130 ± 2 and 165 ± 10 mg/dL with oral and intraperitoneal, respectively) and diabetic rats (155 ± 2 and 240 ± 20 mg/dL with oral, and intraperitoneal, respectively). The diabetic rats were 1.5 fold more sensitive to ZnONPs effect by the intraperitoneal route. In conclusion, this study provides new information about the acute response of ZnONPs on fasting glycemia in diabetic and healthy rat models; these data are essential for possible future clinical approaches.

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Section: Introductionmentioning

confidence: 99%

Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats

et al. 2020

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“…They are also useful in many cosmetics applications such as in makeup, sunscreen, toothpastes and personal care products [1,2]. In the medical domain, TiO 2 NP are used as components for prosthetic implants (hip, knees, dental implants) or in intravenous injection [3][4][5]. TiO 2 NP are also found in other various applications like paint, glass, electronic and water treatment industries [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Toxicity of TiO2 Nanoparticles: Validation of Alternative Models

Leroux

Doumandji

Chézeau

et al. 2020

IJMS

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There are many studies concerning titanium dioxide (TiO2) nanoparticles (NP) toxicity. Nevertheless, there are few publications comparing in vitro and in vivo exposure, and even less comparing air–liquid interface exposure (ALI) with other in vitro and in vivo exposures. The identification and validation of common markers under different exposure conditions are relevant for the development of smart and quick nanotoxicity tests. In this work, cell viability was assessed in vitro by WST-1 and LDH assays after the exposure of NR8383 cells to TiO2 NP sample. To evaluate in vitro gene expression profile, NR8383 cells were exposed to TiO2 NP during 4 h at 3 cm2 of TiO2 NP/cm2 of cells or 19 μg/mL, in two settings—submerged cultures and ALI. For the in vivo study, Fischer 344 rats were exposed by inhalation to a nanostructured aerosol at a concentration of 10 mg/m3, 6 h/day, 5 days/week for 4 weeks. This was followed immediately by gene expression analysis. The results showed a low cytotoxic potential of TiO2 NP on NR8383 cells. Despite the absence of toxicity at the doses studied, the different exposures to TiO2 NP induce 18 common differentially expressed genes (DEG) which are involved in mitosis regulation, cell proliferation and apoptosis and inflammation transport of membrane proteins. Among these genes, we noticed the upregulation of Ccl4, Osm, Ccl7 and Bcl3 genes which could be suggested as early response biomarkers after exposure to TiO2 NP. On the other hand, the comparison of the three models helped us to validate the alternative ones, namely submerged and ALI approaches.

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“…Based on the notion that the silica coating of commercial TiO 2 NP-based UV filters undergoes a fast degradation once released into aquatic media (88–98% silica removal within 96 h) [ 44 ], we speculated that the T-AVO in contact with cells after 72 h of exposure consisted of mainly pure rutile. Worth noting is the fact that not only the shape but also the crystal composition of TiO 2 particles (e.g., T-AVO: Pure rutile; P25: Anatase:Rutile) makes their use more or less safe, as documented in the literature [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Safety Evaluation of TiO2 Nanoparticle-Based Sunscreen UV Filters on the Development and the Immunological State of the Sea Urchin Paracentrotus lividus

et al. 2020

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Sunscreens are emulsions of water and oil that contain filters capable of protecting against the detrimental effects of ultraviolet radiation (UV). The widespread use of cosmetic products based on nanoparticulate UV filters has increased concerns regarding their safety and compatibility with both the environment and human health. In the present work, we evaluated the effects of titanium dioxide nanoparticle (TiO2 NP)-based UV filters with three different surface coatings on the development and immunity of the sea urchin, Paracentrotus lividus. A wide range of NP concentrations was analyzed, corresponding to different levels of dilution starting from the original cosmetic dispersion. Variations in surface coating, concentration, particle shape, and pre-dispersant medium (i.e., water or oil) influenced the embryonic development without producing a relevant developmental impairment. The most common embryonic abnormalities were related to the skeletal growth and the presence of a few cells, which were presumably involved in the particle uptake. Adult P. lividus immune cells exposed to silica-coated TiO2 NP-based filters showed a broad metabolic plasticity based on the biosynthesis of metabolites that mediate inflammation, phagocytosis, and antioxidant response. The results presented here highlight the biosafety of the TiO2 NP-based UV filters toward sea urchin, and the importance of developing safer-by-design sunscreens.

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Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Cited by 422 publications

References 114 publications

Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats

Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats

Toxicity of TiO2 Nanoparticles: Validation of Alternative Models

Safety Evaluation of TiO2 Nanoparticle-Based Sunscreen UV Filters on the Development and the Immunological State of the Sea Urchin Paracentrotus lividus

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