Hydroxypropyl‐β‐cyclodextrin hybrid nanogels as nano‐drug delivery carriers to enhance the solubility of dexibuprofen: Characterization, in vitro release, and acute oral toxicity studies

Khalid, Qandeel; Ahmad, Mahmood; Minhas, Muhammad Usman

doi:10.1002/adv.21876

Cited by 34 publications

(32 citation statements)

References 54 publications

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“…Similar results were found in the case of mononer (AMPS). This is due to the hydrophilic nature of polymer and monomer and due to more cross-linked points in the system (49). The percent drug-loading content in nanogels was also increased with increasing polymer and monomer concentration.…”

Section: In Vitro Dissolution Studymentioning

confidence: 98%

“…After this, the reflux condensation was carried out for 4-5 h at 75-85°C to complete polymerization and cross-linking in aqueous medium. After when solvent was distilled out, white fluffy gels was collected, sieved, and dried in oven at 40°C for 24 h (48,49). The supposed schematic diagram for the chemically cross-linked nanogels have illustrated in Fig.…”

Section: Preparation Of Nanogelsmentioning

confidence: 99%

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RETRACTED ARTICLE: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation

2020

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Current study is focused to enhance the solubility of poorly soluble drug olanzapine (OLZ) by nanogels drug delivery system, as improved solubility is one of the most important applications of nanosystems. Poor solubility is a major issue, and 40% of marketed and about 75% of new active pharmaceutical ingredients are poorly water soluble which significantly affect the bioavailability and therapeutic effects of these drugs. In this study, nanogels, a promising system for solubility enhancement, were developed by freeradical polymerization technique. Different formulations were synthesized in which poloxamer-407 was cross-linked with 2-acrylamido-2-methylpropane sulfonic acid (AMPS) with the help of cross-linker methylene bisacrylamide (MBA). The chemically cross-linked nanogels were characterized by Fourier transform infrared spectroscopy (FT-IR), thermos gravimetric analysis (TGA), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta size, swelling, sol-gel analysis, drug loading, solubility, and in vitro drug release studies. In order to determine the biocompatibility and cytotoxicity of nanogels to biological system, toxicity study on rabbits was also carried out. It was confirmed that the developed nanogels was thermally stable, safe, effective, and compatible to biological system, and the solubility of olanzapine (OLZ) was enhanced up to 38 folds as compared with reference product.

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Section: In Vitro Dissolution Studymentioning

confidence: 98%

Section: Preparation Of Nanogelsmentioning

confidence: 99%

RETRACTED ARTICLE: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation

2020

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“…To enhance solubility and dissolution, pharmaceutical researchers have used various approaches (Khalid et al. 2018 ; Vikas et al. 2018 ; Giri et al.…”

Section: Introductionmentioning

confidence: 99%

Enhanced oral bioavailability of koumine by complexation with hydroxypropyl-β-cyclodextrin: preparation, optimization, ex vivo and in vivo characterization

et al. 2021

Drug Delivery

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“…In vivo preclinical studies show no toxic effects of DXI, confirming the biocompatibility of the developed nanogels. However, in vivo therapeutic effects have not yet been reported [ 76 ].…”

Section: Novel Strategies For Dexibuprofen Drug Deliverymentioning

confidence: 99%

Dexibuprofen Therapeutic Advances: Prodrugs and Nanotechnological Formulations

Gliszczyńska

2021

Pharmaceutics

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S-(+) enantiomer of ibuprofen (IBU) dexibuprofen (DXI) is known to be more potent than its R-(−) form and exhibits many advantages over the racemic mixture of IBU such as lower toxicity, greater clinical efficacy, and lesser variability in therapeutic effects. Moreover, DXI potential has been recently advocated to reduce cancer development and prevent the development of neurodegenerative diseases in addition to its anti-inflammatory properties. During the last decade, many attempts have been made to design novel formulations of DXI aimed at increasing its therapeutic benefits and minimizing the adverse effects. Therefore, this article summarizes pharmacological information about DXI, its pharmacokinetics, safety, and therapeutic outcomes. Moreover, modified DXI drug delivery approaches are extensively discussed. Recent studies of DXI prodrugs and novel DXI nanoformulations are analyzed as well as reviewing their efficacy for ocular, skin, and oral applications.

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Hydroxypropyl‐β‐cyclodextrin hybrid nanogels as nano‐drug delivery carriers to enhance the solubility of dexibuprofen: Characterization, in vitro release, and acute oral toxicity studies

Cited by 34 publications

References 54 publications

RETRACTED ARTICLE: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation

RETRACTED ARTICLE: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation

Enhanced oral bioavailability of koumine by complexation with hydroxypropyl-β-cyclodextrin: preparation, optimization, ex vivo and in vivo characterization

Dexibuprofen Therapeutic Advances: Prodrugs and Nanotechnological Formulations

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