Protective effect of phenylalanine and glycine on chloramphenicol-induced bone marrow toxicity in albino rats infected with &lt;i&gt;Klebsiella Pneumoniae&lt;/i&gt;

Enendu, A.C.; Unekwe, PC; Esimone, Charles Okechukwu; Obi, Ejeatuluchukwu; Chilaka, Kingsley Chimsorom

doi:10.4314/ijbcs.v10i1.28

Cited by 4 publications

(6 citation statements)

References 22 publications

(33 reference statements)

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“…The significant reduction in PCV, RBC and Hb values in groups 3 and 4 may suggest drug-induced toxicity, characterized by excessive destruction of red blood cells resulting in anaemia (Enendu et al, 2016). It may also be due to loss of erythrocytes as a result of gastrointestinal bleeding.…”

Section: Discussionmentioning

confidence: 99%

Haematological and biochemical studies on the effect of diclofenac sodium on Wistar <i>Rattus norvegicus</i>

Orinya¹,

Adenkola²,

Ogbe³

2017

Int. J. Bio. Chem. Sci

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Diclofenac sodium is a non-steroidal anti-inflammatory drug commonly used worldwide for the treatment of inflammation and pain due to arthritis or other ailments in man and animals. Despite these benefits, there are concerns that this drug may have adverse effect on animal's liver and kidneys. This work was designed to determine the effect of diclofenac sodium on blood components using haematological tests, as well as determine the hepatotoxic and nephrotoxic effects using biochemical assays. Twenty rats were randomly divided into four groups with 5 rats per group. The groups 2, 3, and 4 were assigned rats, intramuscularly administered diclofenac sodium at the doses of 49.05, 98.10 and 147.15 mg/kg body weight respectively, once a day for seven days while group 1 rats were given distilled water only, and served as control. The blood collected was tested by haemoanalyzer while the serum was assayed by biochemistry analyzer. The various doses of diclofenac sodium produced significant (p<0.05) decrease in the values of haemoglobin concentration, packed cell volume, red blood cells and white blood cells while there was significant (p<0.05) increase in the levels of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, urea, creatinine, total cholesterol, triglycerides and electrolytes. However, there was significant (p<0.05) decrease in the levels of serum total protein, albumin, glucose and HDLcholesterol. The results therefore showed that diclofenac sodium may have deleterious effect on animal tissues, resulting in hepatic and renal impairments at the given doses and treatment duration. So caution needs to be exercised in its administration, which should be limited to the lowest therapeutic doses, to prevent its harmful effect.

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Section: Discussionmentioning

confidence: 99%

Haematological and biochemical studies on the effect of diclofenac sodium on Wistar <i>Rattus norvegicus</i>

Orinya¹,

Adenkola²,

Ogbe³

2017

Int. J. Bio. Chem. Sci

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“…stimulated a significant reduction in the RBCs, Hb, HCT and WBCs but the platelets count revealed a significant increase compared to the control rats. These results suggested that the hematotoxic effects of DS administration to the rats characterized by excessive destruction of red blood cells resulting in anemia (Enendu et al, 2016). It may also be due to loss of erythrocytes as a result of gastrointestinal bleeding.…”

Section: Discussionmentioning

confidence: 85%

Hematological and renoprotective effects of folic acid and lentil extract in diclofenac sodium exposed rats

Abdel-Rahman

Abdel-Baky

2023

Braz. J. Biol.

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Excessive intake of non-steroidal anti-inflammatory drugs such as, diclofenac sodium (DS) may lead to toxicity in the rats. In this work, we aimed to examine the protective impact of lentil extract (LE) and folic acid (FA) on the hematological markers, the kidney tissue oxidative stress and the renal function against diclofenac sodium (DS) in male albino rats. The rats (120-150 g) were divided into four equal groups randomly, the first group kept as the untreated control. The second group was administrated with DS (11.6 mg/kg b.wt. orally once/day). The third group was received DS+FA (11.6 mg/kg b.wt.+76.9 microgram/kg b.wt.) orally once/day. The fourth group was treated with DS+LE (11.6 mg/kg b.wt.+500 mg/kg b.wt.) orally once/day. After four weeks, the results revealed that DS produced a significant decrease in the values of red blood cells (RBCs), hemoglobin concentration (Hb), hematocrit (HCT) and white blood cells (WBCs). On the other hand, there was a significant increase in the platelets count. Also, DS induced a renal deterioration; this was evidenced by the significant increase in the serum levels of urea, creatinine, uric acid, Na, Ca, Mg as well as the nitric oxide (NO) level in the kidney tissue. Also, there were a significant reduction in the serum levels of potassium (K) and reduced glutathione (GSH) in the kidney homogenates. Moreover, the findings in the rats treated by DS+LE or DS+FA showed a potential protection on the hematological markers, oxidative stress in the kidney tissue and the renal function disturbed by DS. LE and FA could play a potent role for the prevention the adverse hematological, the kidney tissue oxidative stress and the renal dysfunction caused by DS via their anti-oxidative and bioactive phytochemicals.

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“…The reduction of red blood cells with subsequent anemia was dose-dependent. This anemia results in reduced oxygen-carrying capacity in the blood and the amount of oxygen delivered to the tissues [ 74 , 75 ]. Similar significant alterations of hematological parameters were observed in rats treated with diclofenac sodium [ 75 ] and paracetamol [ 74 ].…”

Section: Discussionmentioning

confidence: 99%

“…This anemia results in reduced oxygen-carrying capacity in the blood and the amount of oxygen delivered to the tissues [ 74 , 75 ]. Similar significant alterations of hematological parameters were observed in rats treated with diclofenac sodium [ 75 ] and paracetamol [ 74 ]. Moreover, the induction of anemia may be attributed to the loss of erythrocytes resulting from gastrointestinal bleeding and ulcers [ 74 , 75 ].…”

Section: Discussionmentioning

confidence: 99%

Aqueous Ginger (Zingiber officinale) Extract Ameliorates the Harmful Effects of High-Dose Lornoxicam in Albino Male Rats

El-Bahr

Elzoghby

Alfattah

et al. 2022

BioMed Research International

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Lornoxicam is a potent oxicam-class nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, and antipyretic effects. Its impacts on many biological functions are not fully understood. We measured various biomarkers in male albino rats provided an oral aqueous ginger extract before IM administration of therapeutic and 2× the therapeutic doses of lornoxicam. The aqueous ginger plant extract was characterized by mass spectroscopy, and its effects were determined by examining free radical scavenging activity, blood parameters, renal and hepatic function, semen quality, proinflammatory cytokines, antioxidant markers, and histopathology. Rats administered lornoxicam had significantly higher liver and kidney function biomarker values, TNF-α, interleukin-6, and sperm abnormalities than the control rats. The overall erythrocyte count, packed cell volume, prostaglandin, and sperm counts were all considerably lower in the experimental animals. Histological changes were found in the liver, spleen, and testes of rats administered lornoxicam alone. In rats, pretreatment with ginger extract reduced the majority of the negative effects of conventional and high dosages of lornoxicam.

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Protective effect of phenylalanine and glycine on chloramphenicol-induced bone marrow toxicity in albino rats infected with <i>Klebsiella Pneumoniae</i>

Cited by 4 publications

References 22 publications

Haematological and biochemical studies on the effect of diclofenac sodium on Wistar <i>Rattus norvegicus</i>

Haematological and biochemical studies on the effect of diclofenac sodium on Wistar <i>Rattus norvegicus</i>

Hematological and renoprotective effects of folic acid and lentil extract in diclofenac sodium exposed rats

Aqueous Ginger (Zingiber officinale) Extract Ameliorates the Harmful Effects of High-Dose Lornoxicam in Albino Male Rats

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