Protective effect of Moringa oleifera leaves against gentamicin-induced nephrotoxicity in rabbits

Ouédraogo, Moustapha; Lamien-Sanou, A.; Ramdé, Norbert W; Ouedraogo, Aimé Sosthène; Ouédraogo, Moussa; Zongo, Salifou; Goumbri, Olga; Duez, Pierre; Guissou, Pierre I.

doi:10.1016/j.etp.2011.11.006

Cited by 74 publications

(49 citation statements)

References 33 publications

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“…Kidney morphology was observed to possess complicated renal damage. M. oleifera ‐treated rabbits were found to normalize the alteration made by gentamicin (Ouédraogo et al ., ). Another study on gentamicin‐induced renal toxicity in rats has shown a beneficial effect from Euclea divinorum .…”

Section: Natural Productsmentioning

confidence: 97%

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Simon

Sabina

2016

J of Applied Toxicology

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The liver is an important organ of the body, which has a vital role in metabolic functions. The non-steroidal anti-inflammatory drug (NSAID), diclofenac causes hepato-renal toxicity and gastric ulcers. NSAIDs are noted to be an agent for the toxicity of body organs. This review has elaborated various scientific perspectives of the toxicity caused by diclofenac and its mechanistic action in affecting the vital organ. This review suggests natural products are better remedies than current clinical drugs against the toxicity caused by NSAIDs. Natural products are known for their minimal side effects, low cost and availability. On the other hand, synthetic drugs pose the danger of adverse effects if used frequently or over a long period. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Natural Productsmentioning

confidence: 97%

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Simon

Sabina

2016

J of Applied Toxicology

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“…An aqueous ethanol (hydroalcohol) extract of M. oleifera leaves was reported to prevent gentamicininduced (80 mg/kg) nephrotoxicity in rabbits at doses of 150 and 300 mg/kg body weight (Ouedraogo et al, 2013). The leaf extract significantly decreased markers of gentamicin-induced kidney toxicity including histological changes, lipid peroxidation, and serum urea and creatinine levels.…”

Section: Animal and In Vitro Studiesmentioning

confidence: 99%

Review of the Safety and Efficacy of Moringa oleifera

Stohs¹,

Hartman²

2015

Phytotherapy Research

398

247

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Moringa oleifera leaves, seeds, bark, roots, sap, and flowers are widely used in traditional medicine, and the leaves and immature seed pods are used as food products in human nutrition. Leaf extracts exhibit the greatest antioxidant activity, and various safety studies in animals involving aqueous leaf extracts indicate a high degree of safety. No adverse effects were reported in association with human studies. Five human studies using powdered whole leaf preparations of M. oleifera have been published, which have demonstrated anti-hyperglycemic (antidiabetic) and anti-dyslipidemic activities. These activities have been confirmed using extracts as well as leaf powders in animal studies. A rapidly growing number of published studies have shown that aqueous, hydroalcohol, or alcohol extracts of M. oleifera leaves possess a wide range of additional biological activities including antioxidant, tissue protective (liver, kidneys, heart, testes, and lungs), analgesic, antiulcer, antihypertensive, radioprotective, and immunomodulatory actions. A wide variety of polyphenols and phenolic acids as well as flavonoids, glucosinolates, and possibly alkaloids is believed to be responsible for the observed effects. Standardization of products is an issue. However, the results of published studies to date involving M. oleifera are very promising. Additional human studies using standardized extracts are highly desirable.

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“…The protective effects of Lcarnitine (LC) on changes in the levels of lipid peroxidation and endogenous antioxidants induced by cisplatin in the liver and kidney tissues of rats was investigated by (Al-Majed et al, 2007;Aleisa et al, 2007) Moringa oleifera (M. oleifera) or drumstick is a member of Moringaceae, and it is grown extensively in many Southeast Asian countries (Leone et al, 2015). Moringa oleifera consists of anti-inflammatory, antihypertensive, antispasmodic, antioxidant, antitumor antipyretic, anti-ulcer, anti-epileptic, diuretic, cholesterol lowering, anti-diabetic, (Paliwal et al, 2011;Sharma et al, 2012), nephroprotective (Ouedraogo et al, 2013) and hepatoprotective activities (Hamza, 2010).…”

Section: Introductionmentioning

confidence: 99%

Morphopathological and Biochemical Changes Induced by Cisplatin as Anticancer Drug and The Protective Role of Moringa Leaf Ethanolic Extract and L-Carnitine in Rat

Salem

Tahoun

Kamel

2019

Journal of Current Veterinary Research

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Cisplatin is a potent, highly effective, broad spectrum chemotherapeutic agent, its clinical application is limited due to its adverse effects on normal tissues Since the pathogenesis of cisplatin-induced toxicities mainly involve free radical and lipid peroxidation, this study was designed to evaluate the protective efficacy of Moringa leaf ethanolic extract and Lcarnitine against cisplatin-nephrotoxicity and hepatotoxicity in rats. 72 male albino rats were divided into 6 groups GI-control received no treatment, GII-cisplatin (7mg/kg for 4 days), GIII-Prophylaxis by Moringa (500mg/kg for 10 days) then cisplatin as in G2, GIV-Prophylaxis by L-Carnitine (200 mg/kg for 10 days) then cisplatin as in G2, GV-treatment by Moringa received cisplatin as group II plus Moringa extract for 14 days. VI-treatment by L-Carnitine received cisplatin as group II plus L-Carnitine for 14 days. The results indicate that cisplatin induced significant increase in serum ALT, AST, Urea, Creatinine and kidney MDA level, also significant decrease in kidney GSH and CAT levels and histopathological changes in kidney tissues as cloudy swelling, necrobiosis changes of tubular epithelium, congestion of glomerular tuft, also hepatic lesions as congestion of the central and portal vein with necrosis of its lining intimal cells, formation of newly formed bile duct with lymphocytic cell infiltrations in portal area and coagulative necrosis of some hepatocytes and another hepatocytes showed hydropic degeneration. Both moringa leaf ethanolic extract and L-carnitine ameliorated these toxicities as evidenced by restoring normal serum ALT, AST, Urea, Creatinine and histopathological architecture of kidney and liver.

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Protective effect of Moringa oleifera leaves against gentamicin-induced nephrotoxicity in rabbits

Cited by 74 publications

References 33 publications

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Review of the Safety and Efficacy of Moringa oleifera

Morphopathological and Biochemical Changes Induced by Cisplatin as Anticancer Drug and The Protective Role of Moringa Leaf Ethanolic Extract and L-Carnitine in Rat

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