Protective effect of ginger (<i>Zingiber officinale</i>) against PCB-induced acute hepatotoxicity in male rats

Khedher, Ahd; Dhibi, Sabah; Akermi, Sarra; Bouzenna, Hafsia; Samout, Noura; Elfeki, Abdelfattah; Hfaïedh, Najla

doi:10.1039/c9ra03136g

Cited by 18 publications

(19 citation statements)

References 57 publications

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“…Treatment of rats with cisplatin (Group III) produced a significant loss of body weight in consistence with results of previous work which attributed that to a loss of adipose tissue as well as skeletal muscles. [20] Loss of body weight is also accompanied by decreased food intake noted during the present experiment.…”

Section: Discussionsupporting

confidence: 69%

Possible protective role of panax ginseng on cisplatin-induced hepatotoxicity in adult male albino rats (Biochemical and Histological Study)

Alrashed

Elkordy

2019

J Microsc Ultrastruct

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Background: Cisplatin is one of the most effective chemotherapy antineoplastic drugs. Panax ginseng is a well-known medicinal herb and has a long history of medicinal use as a tonic to promote health. Aim: This work aimed to study the effect of ginseng on the liver damage induced by cisplatin in rats. It included biochemical and histological investigations. Materials and Methods: Twenty adult rats were divided into four equal groups. Group I served as control. Group II received ginseng orally (100 mg/kg/day) for 4 weeks. Group III animals were injected intraperitoneally with cisplatin in three equal doses (each 3.3 mg/kg) daily for 3 consecutive days. Group IV animals received ginseng together with cisplatin by the same previously mentioned methods and doses. Rats were sacrificed after 4 weeks, and blood samples and liver tissues were collected for biochemical and histological examinations. Results: Cisplatin-induced liver damage manifested biochemically by an increase in serum alanine aminotransferase and aspartate aminotransferase. Histologically, hepatocytes appeared with vacuolated cytoplasm and small dark-stained nuclei with dilatation of blood sinusoids as well as marked accumulation of collagen fibers around enlarged portal tracts. Administration of ginseng together with cisplatin improved the hepatic dysfunctions and damage caused by cisplatin. Conclusion: Ginseng has a protective role in the amelioration of cisplatin-induced hepatotoxicity.

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Section: Discussionsupporting

confidence: 69%

Possible protective role of panax ginseng on cisplatin-induced hepatotoxicity in adult male albino rats (Biochemical and Histological Study)

Alrashed

Elkordy

2019

J Microsc Ultrastruct

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“…Doxorubicin may undergo a one-electron reduction through a metabolic activation by nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome P-450 reductase. This reduction leads to the formation of the free radical semiquinone, which in turn can produce a variety of active ROS/RNS, including hydrogen peroxide (H 2 O 2 ), hydroxyl radical (•OH) and peroxynitrite (ONOO) (Takemura and Fujiwara, 2007;Ahmed, 2013). These species can attack the cell membrane, damage several macromolecular cellular components, cause protein and LPO and consequently lead to apoptosis or death (Shiromwar and Chidrawar, 2011;Ayla et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Effects of Rutin and Quercetin on Doxorubicin-Induced Renocardiotoxicity in Male Wistar Rats

Mahmoud¹,

Ahmed²,

Fahim³

et al. 2020

Adv. Anim. Vet. Sci.

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This study aims to assess the preventive effects of rutin and/or quercetin on doxorubicin-induced kidney and heart injuries and oxidative stress in male Wistar rats. The male Wistar rats, injected with doxorubicin at an intraperitoneal dose 2 mg/kg b.w. 2 days per week for 5 weeks, were orally treated with rutin and/or quercetin with dose level 50 mg /kg b.w. every other day for 5weeks. The treatments of doxorubicin-injected rats with rutin, quercetin and their combination resulted in a significant decrease in the elevated serum creatinine and urea levels reflecting an improvement in kidney function. Similarly, the elevated serum CK-MB and LDH activities were significantly ameliorated as a result of treatments of doxorubicin-injected rats, thereby manifesting an amendment of heart function. The treatments also led to the prevention of the elevated lipid peroxidation and amelioration of the lowered GPx, GST and SOD activities as well as GSH content in kidney and heart as a result of treatment of doxorubicin-injected rats with rutin and quercetin. Also, the treatments remarkably improved doxorubicin-induced deleterious histological alterations in kidney and heart. In conclusion, rutin and/or quercetin may have chemopreventive potentials against doxorubicin-induced nephrocardiotoxicity via suppression of oxidative stress and enhancement of antioxidant defense system.

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“…It was reported that structural integrity of the sinusoids was necessary for the maintenance of normal exchanges of fluids, particles, and metabolites. Impairment of exchange is a major contributing factor of hepatic dysfunction in liver fibrosis [28] . In the present study, the hepatotoxic pathological effect of CLL 4 was ameliorated with partial disappearance of hepatic damage when treatment was combined with 6-gingerol.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, 6-gingerol appeared to play a key role in preservation of the structural integrity of the hepatocellular structures. It was reported that ginger extracts revealed significant inhibitory properties against free radical attack and lipid peroxidation, as well as potent protective effects on hepatocytes against oxidative damage [28,29] . It was reported that daily supplement of ginger extract could increase blood levels of antioxidant enzyme, and decrease oxidative stress blood levels.…”

Section: Discussionmentioning

confidence: 99%

“…The process leading to liver fibrosis resembles the process of wound healing, including inflammation, synthesis of collagenous and noncollagenous extracellular matrix components, and tissue remodeling. The origin of liver fibrogenesis is initiated by the damage of hepatocytes, resulting in the recruitment of inflammatory cells and platelets, and activation of Kupffer cells, with subsequent release of cytokines and growth factors [20,28] . Same explanation was previously stated by other authors, who added that these factors activate hepatic stellate cells which proliferate and transform into myofibroblasts-like cells that deposit large amounts of connective tissue components [20,31] .…”

Section: Discussionmentioning

confidence: 99%

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The possible protective role of 6-gingerol on a model of hepatic injury induced by carbon tetrachloride in adult male albino rats: Histological and immunohistochemical study

Mostafa

Hamam

El-Waseef

2017

Egyptian Journal of Histology

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Introduction: Carbon tetrachloride (CCL 4) is a potent environmental hepatotoxin that was commonly used in industrial applications. The main active component in ginger is 6-gingerol which is responsible for many of its medicinal properties. Aim of the work: To assess the possible protective role of orally administered 6-gingerol on a model of hepatic injury induced by CCL 4 in adult male albino rats. Materials and Methods: Thirty adult male albino rats were used in this study and were divided into three groups. Group I: control group which was further subdivided into three subgroups, group II: received intraperitoneal injection of CCL 4 twice / week for two weeks. Group III: received oral 6-gingerol daily five days before the injection of CCL 4-as in group II-and continued till the end of experiment. After two weeks from last injection of CCL 4. All rats were sacrificed; the right lobe of the liver was taken and processed. Sections stained by H&E, Mallory`s trichrome stain and immunostaining for TNF-α and PCNA were prepared. Morphometric and statistical analysis were also performed. Results: Liver of group II showed hepatocytes with vacuolated cytoplasm and congested hepatic sinusoids. Congested portal veins and dilated bile ducts were also seen at portal tract areas. Increased collagen fibers at the portal tract areas were seen by Mallory's trichrome. Increased intensity of positive immune reaction for TNF-α and PCNA was also observed in this group. In group III the liver showed picture nearly similar to that of the control. Morphometric and statistical analysis confirmed the histological and immunohistochemical results. Conclusions: The present work concluded that 6-gingerol could provide a good protection of the liver in a model of hepatic injury induced by CCL 4 .

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Protective effect of ginger (Zingiber officinale) against PCB-induced acute hepatotoxicity in male rats

Abstract: After absorption by the organism, polychlorinated biphenyls (PCBs) cross cellular membranes and pass into blood vessels and the lymphatic system.

Cited by 18 publications

References 57 publications

Possible protective role of panax ginseng on cisplatin-induced hepatotoxicity in adult male albino rats (Biochemical and Histological Study)

Possible protective role of panax ginseng on cisplatin-induced hepatotoxicity in adult male albino rats (Biochemical and Histological Study)

Effects of Rutin and Quercetin on Doxorubicin-Induced Renocardiotoxicity in Male Wistar Rats

The possible protective role of 6-gingerol on a model of hepatic injury induced by carbon tetrachloride in adult male albino rats: Histological and immunohistochemical study

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