Possible protective role of panax ginseng on cisplatin-induced hepatotoxicity in adult male albino rats (Biochemical and Histological Study)

Abstract

Background: Cisplatin is one of the most effective chemotherapy antineoplastic drugs. Panax ginseng is a well-known medicinal herb and has a long history of medicinal use as a tonic to promote health. Aim: This work aimed to study the effect of ginseng on the liver damage induced by cisplatin in rats. It included biochemical and histological investigations. Materials and Methods: Twenty adult rats were divided into four equal groups. Group I served as control. Group II received ginseng orally (100 mg/kg/day) for 4 weeks. Group III animals were injected intraperitoneally with cisplatin in three equal doses (each 3.3 mg/kg) daily for 3 consecutive days. Group IV animals received ginseng together with cisplatin by the same previously mentioned methods and doses. Rats were sacrificed after 4 weeks, and blood samples and liver tissues were collected for biochemical and histological examinations. Results: Cisplatin-induced liver damage manifested biochemically by an increase in serum alanine aminotransferase and aspartate aminotransferase. Histologically, hepatocytes appeared with vacuolated cytoplasm and small dark-stained nuclei with dilatation of blood sinusoids as well as marked accumulation of collagen fibers around enlarged portal tracts. Administration of ginseng together with cisplatin improved the hepatic dysfunctions and damage caused by cisplatin. Conclusion: Ginseng has a protective role in the amelioration of cisplatin-induced hepatotoxicity.

Possible Protective Role of Sodium Salicylate Nanoemulsion and Ginger on Cisplatin‑induced Hepatotoxicity in Rats (Biochemical and Histopathological Study)

“…Those results were also supported by histopathological examination of the liver which showed that administration of cisplatin induced variousdegenerative changes in the liver tissue, including necrosis, hemorrhage, increased eosinophilic staining, pyknotic nuclei cells, congestion, and mononuclear cellinfiltration which confirmed the biochemical evidence of the oxidative stress. These results are in agreement with Alrashed et al (2019) [4]. In contrast, protection with ginger and/or Bt-Sc-NPs before and after cisplatin obviously improved the histopathological changes induced by cisplatin.…”

“…In our current study these results were confirmed by the histopathological analysis which showed that there were histopathological alterations in the liver tissue, including necrosis, hemorrhage, increased eosinophilic staining, pyknotic nuclei cells, congestion, and mononuclear cell infiltration in the group injected with cisplatin. Our results were in agreement with those of [4,35]. On the other hand histopathological examination of carrier, Bt-Sc-NPs and ginger groups showed that almost the hepatic structure appear normal except few Kupffer cells and blood sinusoids which confirm the safety and nontoxicity of these supplemented agents.…”

“…Nowadays, liver damage becomes a very common cause of various metabolic disorders and can lead to even mortality [3]. One of the most important functions of the liver is the conversion of drugs into products that are more easily excreted [4]. Cisplatin (Cis-diamminedichloroplatinum II) which is one of the platinum-containing chemotherapeutic agents that are highly effective antineoplastic drug [5].…”

Ameliorative effects of Ellagic acid against toxicity of cisplatin in male rats

“…and Elkomy, Abdelhiee [33]. In agreement with Alrashed and El-Kordy [34]. Enlargement of portal tracts with dilatation of branches of portal veins and proliferation of bile ductules was observed.…”

Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects

“…discovered that CP-induced hepatotoxicity was alleviated by PG . In CP-induced liver-damaged rats, PG decreased the levels of serum alanine aminotransferase and aspartate aminotransferase while alleviating hepatic damage [ 75 ]. Another study discovered that the hepatoprotective potential of PG was correlated with its antioxidant, anti-apoptotic, and anti-inflammatory effects in CY-treated rats [ 76 ].…”