This study aims to assess the preventive effects of rutin and/or quercetin on doxorubicin-induced kidney and heart injuries and oxidative stress in male Wistar rats. The male Wistar rats, injected with doxorubicin at an intraperitoneal dose 2 mg/kg b.w. 2 days per week for 5 weeks, were orally treated with rutin and/or quercetin with dose level 50 mg /kg b.w. every other day for 5weeks. The treatments of doxorubicin-injected rats with rutin, quercetin and their combination resulted in a significant decrease in the elevated serum creatinine and urea levels reflecting an improvement in kidney function. Similarly, the elevated serum CK-MB and LDH activities were significantly ameliorated as a result of treatments of doxorubicin-injected rats, thereby manifesting an amendment of heart function. The treatments also led to the prevention of the elevated lipid peroxidation and amelioration of the lowered GPx, GST and SOD activities as well as GSH content in kidney and heart as a result of treatment of doxorubicin-injected rats with rutin and quercetin. Also, the treatments remarkably improved doxorubicin-induced deleterious histological alterations in kidney and heart. In conclusion, rutin and/or quercetin may have chemopreventive potentials against doxorubicin-induced nephrocardiotoxicity via suppression of oxidative stress and enhancement of antioxidant defense system.
The presented study was performed to verify whether rutin and/or quercetin can inhibit liver injury induced by doxorubicin (DXR) in male Wistar rats. In this study, male Wistar rats were treated via the oral route with rutin and quercetin (50 mg/kg) either alone or in combination every other day for five weeks concomitant with receiving intraperitoneal DXR (2 mg/kg) two times a week for five successive weeks. Quercetin, rutin, and their combination significantly improved the deteriorated serum AST, ALT, and ALP activities and total bilirubin level, as well as albumin, AFP, and CA 19.9 levels in DXR-injected rats. Treatments of the DXR-injected group with quercetin and rutin prevented the elevation in liver lipid peroxidation and the reduction in superoxide dismutase, glutathione-S-transferase and glutathione peroxidase activities, and glutathione content. Treatments with quercetin and rutin significantly repressed the elevated expression of liver p53 and TNF-α and enhanced Nrf2 expression. Furthermore, the treatments significantly reduced DXR-induced liver histological changes. In conclusion, rutin and quercetin either alone or in combination may have potential preventive effects against DXR-induced hepatotoxicity through inhibiting oxidative stress, inflammation, and apoptosis as well as modulating the Nrf2 expression.
The goal of this study is to Correlate between Vitamin D receptor polymorphism (FOKI) and lupus nephritis. Eighty subjects were included in this study. They were divided into two groups as follows: Control group: consisted of twenty apparently healthy volunteers of comparable age and socioeconomic status to the patients group. Patients group: consisted of sixty patients with SLE.They were selected from the Internal Medicine departement and Rheumatology out patient clinic of Beni-suef University hospital. In this study, Regarding CBC changes ,The prevalence of thrombocytopenia and lymphopenia was significantly higher among SLE patients compared to our controls, However the prevalence of lymphopenia and leucopenia was significantly higher among SLE patients with GG genotype compared to SLE patients with AG and AA mutants ,Regarding liver function tests, The mean serum Albumin level was significantly lower among SLE patients compared to controls .Antinuclear antibody titre was significantly higher among SLE patients than controls ,Also Anti Ds DNA is represented in SLE patients in ahigh titre than healthy controls ,Furthermore, All SLE patients with GG genotypes had positive Anti Ds DNA( 100%) compared to SLE patients with AG ( 0,0) and AA ( 0,0) mutants. It is recommended to carry out further studies on FOKI gene polymorphisms in larger groups of patients and controls.
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