Protective effect of baicalin on the small intestine in rats with food allergy

Yan, Xiumei; Yan, Jingbin; Huang, Kaiyu; Pan, Tongtong; Xu, Zuojun; Lu, Huajun

doi:10.1016/j.lfs.2017.09.036

Cited by 11 publications

(7 citation statements)

References 13 publications

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“…Rutin, hyperoside, isoquercitrin, taxifolin, quercitrin, hesperidin, myricetin, baicalin, neohesperidin dihydrochalcone, and quercetin are common flavonoids in plants, all of which have good biological activities and have positive effects on many diseases (Selloum et al, 2003;Ku et al, 2015;Li, Zhang, Liu, Liu, & Dong, 2016;Matsuda et al, 2007;Ma, Luo, Jiang, & Liu, 2016;Yan & Hu, 2004;Tong, Zhou, Wang, Yang, & Cao, 2009;Yan et al, 2017;Bar, Borrego, Benavente, Castillo, & Rio, 1990;Rivera, Morón, Sánchez, Zarzuelo, & Galisteo, 2008). All of these 10 compounds have good anti-inflammatory effects (Bar et al, 1990;Ku et al, 2015;Li et al, 2016;Ma et al, 2016;Matsuda et al, 2007;Rivera et al, 2008;Tong et al, 2009;Yan et al, 2017;Yan & Hu, 2004). Hyperoside and neohesperidin dihydrochalcone have protective effects on gastrointestinal mucosa and can regulate gastrointestinal function (Bar et al, 1990;Ku et al, 2015).…”

Section: Composition Of Mplfmentioning

confidence: 99%

“…Hyperoside and neohesperidin dihydrochalcone have protective effects on gastrointestinal mucosa and can regulate gastrointestinal function (Bar et al, 1990;Ku et al, 2015). Taxifolin and hesperidin have bacteriostatic effect, which can kill harmful bacteria in the intestine and keep the intestine healthy (Matsuda et al, 2007;Yan et al, 2017). Baicalin not only has bacteriostatic effect, but also has the effect of stopping diarrhea and vomiting (Yan et al, 2017).…”

Section: Composition Of Mplfmentioning

confidence: 99%

“…Taxifolin and hesperidin have bacteriostatic effect, which can kill harmful bacteria in the intestine and keep the intestine healthy (Matsuda et al, 2007;Yan et al, 2017). Baicalin not only has bacteriostatic effect, but also has the effect of stopping diarrhea and vomiting (Yan et al, 2017). MPLF contained these 10 compounds, which directly or cooperatively form the biological activities of MPLF, and made it produce the activity of antidiarrhea.…”

Section: Composition Of Mplfmentioning

confidence: 99%

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Intervention effect of Malus pumila leaf flavonoids on senna‐induced acute diarrhea in BALB/c mice

Tian

Tan

et al. 2020

Food Science & Nutrition

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The Malus pumila leaves are used as a kind of tea drink in China, and there are abundant flavonoids in the leaves of Malus pumila. In this study, BALB/c mice received senna extract solution via gavage, which induced acute diarrhea, and the interventive effect of Malus pumila leaf flavonoids (MPLF) was observed. The results showed that MPLF decreased the diarrhea index, and MPLF also decreased the capillary permeability in the abdominal cavity of mice. The result of serum cytokine detection indicated that MPLF decreased the levels of inflammatory cytokines, including interleukin 6 (IL-6), interleukin 12 (IL-12), and tumor necrosis factor alpha (TNF-α).The results of quantitative polymerase chain reaction (qPCR) indicated that diarrhea decreased the mRNA and protein expression of aquaporin-3 (AQP3) in the jejunum and aquaporin-4 (AQP4) in the ileum, which were inhibited by MPLF. By high performance liquid chromatography (HPLC), MPLF mainly contains 10 flavonoids, which are rutin, hyperoside, isoquercitrin, taxifolin, quercitrin, hesperidin, myricetin, baicalin, neohesperidin dihydrochalcone and quercetin, the synergistic effect of these components plays an antidiarrhea role in MPLF. Therefore, MPLF achieved good antidiarrheal effect, which was better than that of the commonly used montmorillonite powder at the same concentration. MPLF is a natural raw material for functional food with an antidiarrheal effect. K E Y W O R D S acute diarrhea, aquaporin, expression, flavonoid, Malus pumila leaf How to cite this article: Yi R, Tian Y, Tan F, et al. Intervention effect of Malus pumila leaf flavonoids on senna-induced acute diarrhea in BALB/c mice. Food Sci Nutr. 2020;8:2535-2542

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Section: Composition Of Mplfmentioning

confidence: 99%

Section: Composition Of Mplfmentioning

confidence: 99%

Section: Composition Of Mplfmentioning

confidence: 99%

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Intervention effect of Malus pumila leaf flavonoids on senna‐induced acute diarrhea in BALB/c mice

Tian

Tan

et al. 2020

Food Science & Nutrition

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“…By contrast, increased intake of vegetable oil rich in n-6 PUFAs has been described to promote allergenic response to whey proteins [136]. Other dietary components that have been associated with prevention of sensitization to food allergens include polyphenols, in particular flavonoids [137][138][139]. Thus, manipulation of dietary components may help to prevent development of food allergies.…”

Section: Other Dietary Factorsmentioning

confidence: 99%

Immune Basis of Allergic Reactions to Food

Lozano‐Ojalvo

Berin

Tordesillas

2019

J Investig Allergol Clin Immunol

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Food allergies are diseases where the normal tolerance response to oral antigens is altered. Recent advances have begun to uncover mechanisms that mediate sensitization to food allergens and maintenance of the disease. Production of alarmins by epithelial cells triggers a cascade that leads to allergen-specific IgE synthesis. IL-9 has also been shown to play a role in mast cell recruitment and amplification of the allergic response. In recent years, increasing evidence suggests that sensitization to food allergens can be developed via nonoral routes, in particular the skin, thus leading to the "dual exposure hypothesis". Environmental factors such as diet or microbiota can shape the immune system to promote tolerance or sensitization to food antigens. While the mechanism of primary tolerance to food antigens is quite clear, that leading to permanent tolerance in food-allergic individuals through immunotherapy is still under study. Understanding the mechanisms by which oral tolerance is suppressed and sensitization develops will help to identify new targets to develop combined therapies for the treatment of food allergies.

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“…All of these components were shown to have anti-allergic properties by preventing allergic sensitization. Effects include the reduction in IgE levels, lowering the amount of effector T-cells, increasing the amount of Treg cells and preventing DC maturation and, therefore, T-cell antigen presentation[70][71][72][73][74]. In contrast, one study also shows that quercetin, in a mouse model for egg allergy, increases Th2 levels and IL-1β and NO levels[75].…”

mentioning

confidence: 99%

Contribution of Dietary PUFAs and Micronutrients in the Protection against Food Allergy Development

Hoppenbrouwers¹,

Jh²,

Garssen³

et al. 2018

Preprint

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Specific nutrients including n-3 long chain polyunsaturated fatty acids (LCPUFAs), flavonoids, vitamin A, D and E are considered to possess protective properties on human health by impacting on immunological reactions. An ‘inflammation-suppressive’ effect appears to be the common denominator of the beneficial effects of most of these dietary components which may protect against the development of chronic immune disorders such as allergy. However, the majority of these promising data are from preclinical studies such as animal disease models, as the majority of clinical studies only indicate associations. PUFAs, especially n-3 LCPUFAs, have been shown to interact with both the sensitization as well as the effector phase in food allergy. However, it should be noted and realised that PUFAs are highly susceptible to lipid oxidation. Flavonoids and fat-soluble vitamins both contain anti-inflammatory properties and are able to act as anti-oxidants as well. Here, we explore the anti-allergic properties of PUFAs, flavonoids and fat-soluble vitamins in order to create an overview and, more importantly, suggest a strategy to target food allergies using these components and combinations thereof. Dietary n-3 LCPUFAs and the above mentioned micronutrients are promising anti‐allergy agents capable of influencing the allergic immune response through multiple and different biological pathways.

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Protective effect of baicalin on the small intestine in rats with food allergy

Cited by 11 publications

References 13 publications

Intervention effect of Malus pumila leaf flavonoids on senna‐induced acute diarrhea in BALB/c mice

Intervention effect of Malus pumila leaf flavonoids on senna‐induced acute diarrhea in BALB/c mice

Immune Basis of Allergic Reactions to Food

Contribution of Dietary PUFAs and Micronutrients in the Protection against Food Allergy Development

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