Protective Effect of Apitherapy Products Against Carbon Tetrachloride-Induced Hepatotoxicity in Wistar Rats

Andriţoiu, Călin Vasile; Prisãcaru, Anca Irina; Andriţoiu, V.; Popa, Ionel Marcel

doi:10.1016/s0953-6205(11)60020-4

Cited by 11 publications

(17 citation statements)

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“…CCl4 intoxicated group also showed significantly increased serum urea and creatinine level with severe necrotic degeneration of both glomeruli and tubules ( Figure 2 to Figure 6). The results of CCl4 were similar to Sakrand and Lamfon 23 , Andriţoiu et al, 24 , Mohamed et al, 25 and Hermenean et al, 26 .…”

Section: Discussionsupporting

confidence: 81%

Ameliorative Effect of Broccoli Powder on Renal Toxicity in Mice Caused by Continuous Exposure to Escitalopram Antidepressant Drug

Saxena¹,

Shahani²

2017

Int. Res. J. Pharm.

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Antidepressants induced metabolic syndrome is a major public health problem in the treatment of psychiatric disorders which leads to an increased risk of cardiovascular disease, non-alcoholic hepatic steatosis and renal dysfunction. Psychiatric disorder is a mental illness that includes depression, schizophrenia, and anxiety disorder that affect millions of people around the world. The purpose of present study was to investigate the protective role of broccoli powder against continuous ingestion of antidepressant drug induced nephrotoxicity in Swiss albino mice. In present study mice were continuously treated with escitalopram antidepressant drug (20 mg/kg/b.w. orally) for 4, 8 and 12 weeks. The escitalopram drug intoxicated group showed elevation in serum urea and creatinine level. Escitalopram drug intoxicated group also showed degeneration of glomerulus and renal tubule that are comparable with carbon tetrachloride (33 mg/kg) group considered as positive control. Group that received both broccoli powder and escitalopram drug (200 mg/kg + 20 mg/kg) significantly reduced elevated level of serum urea and creatinine with mild degeneration of glomerulus and renal tubule as compared to antidepressant drug intoxicated group.

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Section: Discussionsupporting

confidence: 81%

Ameliorative Effect of Broccoli Powder on Renal Toxicity in Mice Caused by Continuous Exposure to Escitalopram Antidepressant Drug

Saxena¹,

Shahani²

2017

Int. Res. J. Pharm.

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“…14,16,20,21,32 The alleviation of the histopathological aspects of toxic compounds by bee products is known in liver, spleen, kidney, and pancreas but not in testis. 21 Bee pollen constitutes a good source of healthy compounds, namely, phenolics, and it might be useful in prevention of diseases in which free radicals are implicated. 14 Pollen intake can improve gut, gastroenterological and liver health.…”

Section: Discussionmentioning

confidence: 99%

“…Apitherapy diets reduce the carbon tetrachloride toxicity in liver, spleen and pancreas in Wistar rats. 21 The positive effect on the intestinal regeneration were found in rats after honey and bee pollen peroral intake. These effects were thought to be a result of the anti-inflammatory and antioxidant properties of bee products.…”

Section: Introductionmentioning

confidence: 98%

Changes in Intestinal Morphology of Rats Fed with Different Levels of Bee Pollen

Toman¹,

Hájková²,

Hluchý³

2015

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Context: Bee pollen has been related to therapeutic properties including antibiotic, antineoplasic, antidiarrhoeic and antioxidant activities. However, little is known about the effect of pollen feeding on the intestinal structures and functions. Aims: The objective of this study was to evaluate the small intestine morphology in rats fed with three different pollen levels. Materials and Methods: Forty rats were randomly separated into 4 groups of 10 rats each. Control group (C) was fed with a basic diet, group L received a diet supplemented with 0.2% (w/w), group M with 0.5% (w/w) and group H with 0.75% (w/w) bee pollen for 90 days. The relative volume of intestinal mucosa structures, length of villi and Lieberkühn crypts formation were evaluated. Results: Quantitative morphometry and histology methods revealed significant increase in the relative volume of epithelium (P<0.0001) and decrease in the connective tissue volume (P<0.0001) of jejunum in groups M and H as compared to the control. The intestinal villi length significantly (P<0.0001) increased in all experimental groups. On the other hand, the Lieberkühn crypts depth significantly (P<0.0001) increased only in groups L and M but decreased (P<0.0001) in the highest pollen-exposed group H. Conclusion: The most significant results were recorded in the medium pollen exposed group. We conclude that the bee pollen concentration of 0.5% is the most effective in the increase of relative volume of the intestinal epithelium and villi length. The results demonstrated that bee pollen affects the small intestine development in a concentration-dependent manner and could be beneficial for intestinal function.Key words: Bee pollen, Histology, morphometry, Rat, Small intestine. PICTORIAL ABSTRACT SUMMARY• Bee pollen enhances the develop ment of the small intestine in rats from 4 weeks to 4 months of age • Intestinal epithelium volume, villi length and crypts depth increase.• Bee pollen acts in a concentration-dependent manner.Abbreviations used: w/w: Percent Concentration Weight/Weight.

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“…For the last few decades, honeybee brood has been attracting ever greater attention as a valuable food (Schmidt & Buchmann, 1992;Krell, 1996;Narumi, 2004;Finke, 2005;Mutsaers et al, 2005;Bogdanov, 2015). Some recent investigations have also confirmed the medicinal properties of honeybee brood (Iliescu, 1993;Vasilenko et al, 2002;2005;Gorpinchenko et al, 2004;Seres et al, 2013;Seres et al, 2014;Andriţoiu et al, 2014). The scientific confirmation of these valuable properties of honeybee brood have become a strong stimulus to commence its commercial production not only Isidirov et al…”

Section: Introductionmentioning

confidence: 90%

“…The storability of honeybee brood homogenate can also be improved by binding fresh homogenate to a glucose-lactose adsorbent (Burmistrova, 1999). Considering the presented material as well as the data included in Table 1, it is possible to classify the drone homogenate to nutraceutics, since apart from its nutritious protein content it also exhibits substantial health effects confirmed not only by recent in vitro and in vivo laboratory investigations (Seres et al, 2013;Andriţoiu et al, 2014), but also by clinical observations (Gorpinchenko et al, 2004). Furthermore, some investigations demonstrated the immunotropic and hepatotropic activity of drone homogenate (Vasilenko et al, 2002;2005).…”

Section: Chemical Composition Of Honeybee Queen and Dronementioning

confidence: 97%

GC-MS investigation of the chemical composition of honeybee drone and queen larvae homogenate

Isidorov

Бакиер

Stocki

2016

Journal of Apicultural Science

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A b s t r a c tHoneybee larva homogenate appears to be underrated and insufficiently explored but this homogenate is an exceptionally valuable honeybee product. Drone larva homogenate is very nutritional due to its high content of proteins, free amino acids, lipids, and carbohydrates. Moreover, the biological characteristics of honeybee larvae indicate the presence of chemical substances that may be pharmacologically active. In spite of the above, the chemical composition of honeybee larva has not gained as much attention as that of other bee products. In this study, the chemical composition of honeybee brood homogenate has been investigated using gas chromatography/mass spectrometry. As a result, it was possible to isolate as many as 115 extractive organic compounds from 6 samples of crude queen and 9 samples of drone homogenate. �he main groups of sub�The main groups of substances extracted from either type of homogenate were composed of free amino acids and carbohydrates. The relative content of amino acids in queen homogenate as well as the share of essential amino acids were found to be higher than in the drone homogenate. Disaccharide trehalose was the dominant sugar in the queen larvae, whilst glucose prevailed in the drone larvae. Comparative chemical analyses of honeybee queen and drone larva homogenates have allowed us to make a preliminary inference about a higher overall value of the former.

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Protective Effect of Apitherapy Products Against Carbon Tetrachloride-Induced Hepatotoxicity in Wistar Rats

Cited by 11 publications

References 0 publications

Ameliorative Effect of Broccoli Powder on Renal Toxicity in Mice Caused by Continuous Exposure to Escitalopram Antidepressant Drug

Ameliorative Effect of Broccoli Powder on Renal Toxicity in Mice Caused by Continuous Exposure to Escitalopram Antidepressant Drug

Changes in Intestinal Morphology of Rats Fed with Different Levels of Bee Pollen

GC-MS investigation of the chemical composition of honeybee drone and queen larvae homogenate

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