Protective and therapeutic effects of dexpanthenol on isoproterenol‐induced cardiac damage in rats

Abstract

The purpose of the study was to explore the protective and therapeutic effects of dexpanthenol (DEX) on isoproterenol (ISO)-induced cardiac damage. Forty rats were distributed into four groups: group I (Control); group II (ISO); ISO (150 mg/kg/day) was given to rats once a day for 2 consecutive days with an interval of 24 h; group III (DEX+ISO): DEX (250 mg/kg) was applied 30 min before the first ISO administration and continued in the next two days after second ISO administration; group IV (ISO+DEX): After the ISO treatment at 1st and 2nd days, DEX was given at 3rd and 4th days. Rats were monitored for mean arterial blood pressure (BP), heart rate, oxygen saturation (%SO ), and electrocardiography (ECG). Heart tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH), total oxidant status (TOS); total antioxidant capacity (TAC), oxidative stress index (OSI), and caspase-3 were determined. BP and SO values indicated a significant decrease in the ISO group. Also, T wave negativity was observed in 6 of 10 rats, SOD, CAT, and GPX levels were significantly lower in ISO group than control group. ISO administration increased TOS and OSI levels, whereas DEX treatment significantly reduced these parameters. Also, ISO-induced morphological alterations such as disorganization of cardiomyocytes, loss of myofibrils and cytoplasmic vacuolization whereas these histological damages were significantly decreased in ISO+DEX and DEX+ISO groups when compared to the ISO group. This study implies the cardioprotective effects of DEX on ISO-induced cardiotoxicity.

The protective effect of kaempferol on heart via the regulation of Nrf2, NF‐κβ, and PI3K/Akt/GSK‐3β signaling pathways in isoproterenol‐induced heart failure in diabetic rats

“…Our findings indicated that hemodynamic parameters such as systolic, diastolic, and mean blood pressures were altered in DC and DC + ISO rats due to the consecutive loss of cell membrane potential in injured myocardium. The results are in line with the previous reports (Ishikawa et al, ; Kalkan et al, ; Mátyás et al, ). Moreover, KF treatment improved systolic, diastolic, and mean blood pressures in DC + ISO rats.…”

Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?

“…A handful of studies looked at the effect of this vitamin on cardiac function in animal models inducing cardiac stress. In rats, dexpanthenol, a precursor of pantothenic acid, is beneficial for the heart during sepsis induced by cecal ligation and puncture [ 192 ] and could also protect the heart from isoproterenol-induced cardiac damage [ 193 ]. This protection could rely on the preservation of antioxidant machinery that would maintain a better antioxidant status of the myocardium; a mechanism already suggested to explain the protective effect of dexpanthenol on cardiovascular damage, especially on endothelial dysfunction, in the type 1 diabetes rat model [ 194 ].…”

“…-protection of the heart during sepsis [192] -protection heart from isoproterenol-induced damage [193] -beneficial effects on endothelial function (type 1 diabetes) [194] B6/B9/B12 Folate supplementation protects diastolic function and prevents fibrosis: monocrotaline-induced hypertrophy [228,229] Supplementation with folate and cobalamin: reduction of cardiac damage (isoproterenol-induced infarction) [231] Human Supplementation with B6/B9/B12: decrease in risk of stroke and myocardial infarction in patients older than 69 [220] Supplementation with folate:…”

Biopharmaceutical and rheometric studies in the development of a gel composition with dimethindene maleate

“…Pantothenic acid is necessary for the formation and regeneration of the skin and mucous membranes. Dexpanthenol is used in topical agents in a dosage of 30-50 mg / 1 g [3,6,7].…”