Prostatic sarcomatoid carcinoma in a dog: cytologic and immunohistochemical findings

Abstract

An 8-year-old neutered male Boxer was presented with tenesmus, hemorrhagic urethral discharge, and dysuria. Abdominal ultrasound and radiographic examinations revealed irregular prostatic enlargement. Laparotomy was performed and intraoperative cytology was done on imprint smears of a biopsy specimen obtained from a prostatic mass. The cytologic preparation was highly cellular and contained a predominant population of atypical, large, loosely cohesive spindle cells, with rare multinucleated cells and mitotic figures. The cytologic findings were consistent with undifferentiated sarcoma. At necropsy, a large cystic prostatic mass and numerous satellite nodules in the soft tissues around the pelvis were found. On histologic examination the tumor was composed primarily of bundles of neoplastic spindle cells. Rare pseudo-acinar structures and signet-ring cells also were observed. On immunohistochemical examination, the neoplastic cells co-expressed cytokeratin and vimentin. Based on histologic and immunohistochemical findings, the tumor was diagnosed as primary prostatic sarcomatoid carcinoma. This is a rare tumor in dogs, in which biphasic morphology of epithelial and mesenchymal cells can complicate the diagnosis, requiring immunochemical stains for confirmation.

Cutaneous metastases of prostatic adenocarcinoma in two dogs

“…Rare mitotic figures and atypical multinucleated cells are usually present. Purple amorphous to granular proteinaceous material can be present in the background of specimens 14 . At the time of presentation, most prostatic adenocarcinomas are locally invasive, with concomitant regional and distant metastases in 70%‐80% of the cases 1,5 .…”

Das Prostatakarzinom des Hundes

“…Bei den Adenokarzinomen gibt es unterschiedliche Differenzierungsformen [44]. Histologisch kann zwischen urothelialen, glandulären, squamoiden und sarkomatösen Anteilen unterschieden werden [13,33,44,46,55]. Dagegen sind mesenchymale Tumoren der Prostata sehr selten [44].…”