A 12-year-old intact male German Shepherd dog was presented to the Tibaldi Veterinary Hospital in Milan with a history of chronic prostatic disease unresponsive to therapy with amoxicillin/clavulanic acid (Synulox; Pfizer Italia Srl.), and then with enrofloxacin (Baytril; Bayer S.p.a.) in association with meloxicam (Metacam; Boehringer Ingelheim Italia S.p.a.). On physical examination, the dog was mildly hyperthermic (39.7°C) with multiple skin nodules that recently appeared on the ventral abdomen (Figure 1). These nodules were irregularly shaped, from 5 to 20 mm in size, hard and not painful on palpation. Hematology and biochemistry evaluations at that time were unremarkable. On abdominal ultrasound, the prostate gland appeared enlarged (73 × 54 mm), irregularly shaped with heterogeneous echogenicity and diffuse mineralized areas admixed with cystic changes. Fine-needle aspiration cytology from some skin nodules showed a single population of pleomorphic individual to cohesive cells found in small clusters with moderate to abundant slightly basophilic cytoplasm. The nuclei were oval with prominent nucleoli and a high degree of cytologic atypia suggestive of
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