Prospective Study of Anticardiolipin Antibodies in Immunized and Untreated Women With Recurrent Spontaneous Abortions

Mannan‐Binding Lectin Deficiency is Associated with Unexplained Recurrent Miscarriage

“…All Scottish RM patients and 125 of the Danish RM patients were investigated for anticardiolipin antibodies by enzyme‐linked immunosorbent assays (ELISA) according to methods published previously [5, 6]. All the Scottish patients were negative for anticardiolipin antibodies of IgG class whereas 20 (16%) of the Danish patients were positive for either IgM or IgG class anticardiolipin.…”

Adverse effects of intradermal allogeneic lymphocyte immunotherapy: acute reactions and role of autoimmunity

“…Another aspect was the possibility that LIT might induce autoimmune disease. This assumption was refuted concerning the antiphospholipid syndrome (Moncayo et al, 1990;Christiansen et al, 1992;Doherty et al, 1992;Kilpatrick, 1992). The above mentioned meta-analysis showed that the incidence of autoimmune disease following LIT (3/1149) did not exceed that of the control group (1/410).…”

Placebo‐controlled trial of active immunization with third party leukocytes in recurrent miscarriage

“…Patients with anticardiolipin antibodies in the absence of lupus anticoagulant were not excluded from the present trial. We have previously reported that the presence of anticardiolipin antibodies did not appear to have any impact on pregnancy outcome either in immunized or placebo infused RM patients (16). A cross sectional study of an obstetric population similarly did not find any increased rate of miscarriage in women positive for these an tibodies (28).…”

“…The women were screened for the presence of a panel of autoantibodies: the lupus anticoagulant, anticardiolipin antibodies, antinuclar antibodies (ANA) and anti-double-stranded deoxyribonucleic-acid (anti-DNA) as described in previous papers (7,16). Before inclusion in the trial and in the first trimester of pregnancy after immunization or placebo infusion, serum from the patients was investigated by the lymphocytotoxic microtechnique against a panel of lymphocytes from 10 to 14 highly selected, HLA-different individuals for the presence of complement dependent lymphocytotoxic antibodies (NIH technique).…”