Placebo‐controlled trial of active immunization with third party leukocytes in recurrent miscarriage

Christiansen, Ole Bjarne; Mathiesen, Ole; Husth, Merete; Lauritsen, Jakob; Grunnet, Niels

doi:10.3109/00016349409023451

Cited by 56 publications

(32 citation statements)

References 35 publications

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“…Five hundred and ninety‐two studies were initially screened. Eighteen randomized trials published in thirteen English literatures and five Chinese literatures were used for analysis . For the primary outcome measure, live births, we calculated an odds ratio and its 95% confidence intervals.…”

Section: Methodsmentioning

confidence: 99%

Allogenic Lymphocyte Immunotherapy for Unexplained Recurrent Spontaneous Abortion: A Meta‐Analysis

Liu

Kang

et al. 2016

American J Rep Immunol

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Allogenic lymphocyte immunotherapy (LIT) as a treatment for unexplained recurrent spontaneous abortion (URSA) is still controversial due to the lack of enough controls to evaluate its effectiveness. Eighteen randomized, placebo-controlled trials with LIT for URSA were included in the meta-analysis. Live birth rates for each group were extracted, and the overall odds ratio (OR) for LIT was calculated. The success rate of treatment group was significantly higher (OR 3.74, 95% CI 3.07 ~ 4.57). LIT performed before and during pregnancy had dramatically improved the live birth rate in women with URSA (OR 4.67, 95% CI 3.70 ~ 5.90). The overall OR was 5.25 (95% CI 4.16 ~ 6.64), which supports a low dose of lymphocytes for treating URSA. Our results indicate that LIT provides a significantly beneficial effect over placebo for URSA. LIT given before and during pregnancy is superior to LIT given only before pregnancy, and the lower doses per treatment (less than 100 × 10 lymphocytes or 100 mL peripheral blood) achieved a better outcome.

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Section: Methodsmentioning

confidence: 99%

Allogenic Lymphocyte Immunotherapy for Unexplained Recurrent Spontaneous Abortion: A Meta‐Analysis

Liu

Kang

et al. 2016

American J Rep Immunol

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“…Carp et al reported that the rate of anomalies in infants was not significantly different between immunized and non-immunized patients [34]. Christiansen et al [35] and Cavalcante et al [36] indicated that the condition of infants born to mothers who had undergone the immunotherapy was not disturbed. We further found that the immunologic parameters were within the normal range in infants born to patients with URA who had undergone the immunotherapy in our serial follow-up study for the infants [37], and Malinowski et al also reported no significant deterioration in the immunologic parameters of infants from patients with URA who had undergone immunization with paternal lymphocytes [38].…”

Section: Discussionmentioning

confidence: 99%

“…Although the efficacy of this modality has been controversial, an analysis of controlled clinical trials revealed the efficacy for patients with Unexplained Recurrent Abortion (URA) [7,14,19,26,27], especially for those who were negative for blocking antibodies evaluated by a mixed lymphocyte culture reaction between spouses (MLR-BAbs) [19,22,[28][29][30][31][32][33]. The outcome of pregnancies, especially the condition of infants (such as the body weight of infants or the number of gestational weeks at which the infants were born) of patients after this immunotherapy, has not been fully elucidated, although some articles suggested absence of harmfulness of this immunotherapy for the infants born to immunized patients [34][35][36][37][38][39]. On the other hand, there is possibility that the above-mentioned MLR-BAbs, which are considered to be directed against paternal or fetal antigens, might adversely affect fetal growth.…”

Section: Introductionmentioning

confidence: 99%

Studies on the Infants Born to the Patients with Unexplained Recurrent Abortion Who Underwent Immunotherapy using their Husband’s Lymphocytes

Takakuwa¹

2017

Austin J Obstet Gynecol

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Purpose: To investigate the condition of infants born to the patients who underwent Immunotherapy with the Husband's Lymphocytes (LIT) for unexplained recurrent abortion.Method: LIT was performed for the patients with unexplained recurrent abortion, and the pregnancy continued in 129 cases after LIT. The Gestational Weeks at Delivery (GW), the Body Weights (BW) of the infants, as well as major complications, were analyzed in these patients. As a control, the pregnancy outcome was analyzed in 243 cases with no complications and who did not receive LIT.Results: Of 125 cases with singleton pregnancy (4 cases were excluded because of twins), the pregnancy terminated at term in 113 (90.4%), which was not significantly different from that in the control group (209/243, 86.0%, by the Chi-square test). The average GW and BW of infants in the study population and control group were 38W4D ± 2W0D and 38W4D ± 2W3D, 2968 ± 529g and 2904 ± 583g, respectively (not significant by non-paired t-test). There were also no significant differences in the rates of low birth weight and major complications between the two groups. Conclusion:The outcome of pregnancies, especially the condition of infants, of patients after LIT was not significantly different from that of a control population.

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“…However, reports by other investigators have disputed the efficiency of alloimmunization [20][21][22][23][24][25]. Scott et al, recently reviewed most of controlled trials and concluded that immunotherapies to prevent recurrent miscarriages were not effective [26].…”

Section: To Reject or Not Reject: Alloimmuniza-tion Is The Answermentioning

confidence: 94%

AIDS Vaccines and Reproductive Immunology

Bourinbaiar¹,

Jirathitikal²,

Silin³

et al. 2007

CIR

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It may appear that problems of reproductive immunology have little in common with issues of treatment and prevention of AIDS. However, the certain aspects of HIV immunopathogenesis are closely related to problems faced by reproductive immunologists. The development of prophylactic and therapeutic AIDS vaccines would greatly benefit from acquired experience in immune regulation of reproductive dysfunction. The spermatozoa and HIV are foreign intruders that must enter the host cell, oocyte or T-lymphocyte, in order to start the replication process. The immune responses of the host organism against fertilized egg or HIV-impregnated lymphocyte must be similar, since in theory they are directed against alloantigens presented by such cells. This paper attempts to bring together the recent advances in AIDS field with progress made in the physiology and pathology of reproduction in humans, especially in the domain of immunotherapy and prevention of recurrent spontaneous abortions (RSA). It is our opinion that the lessons learned from alloimmunization trials of infertile women are relevant to prophylactic and therapeutic strategies for HIV infection.

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Placebo‐controlled trial of active immunization with third party leukocytes in recurrent miscarriage

Abstract: Active immunization did not provide any benefit in the overall group of women with recurrent miscarriages. However, among women with primary recurrent miscarriages it may improve outcome with respect to the number of livebirths and birthweight.

Cited by 56 publications

References 35 publications

Allogenic Lymphocyte Immunotherapy for Unexplained Recurrent Spontaneous Abortion: A Meta‐Analysis

Allogenic Lymphocyte Immunotherapy for Unexplained Recurrent Spontaneous Abortion: A Meta‐Analysis

Studies on the Infants Born to the Patients with Unexplained Recurrent Abortion Who Underwent Immunotherapy using their Husband’s Lymphocytes

AIDS Vaccines and Reproductive Immunology

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