Prognosis of Malignant Mammary Tumor in 53 Cats.

Ito, Teruo; Kadosawa, Tsuyoshi; Mochizuki, Manabu; Matsunaga, Satoru; Nishimura, Ryohei; Sasaki, Nobuo

doi:10.1292/jvms.58.723

Cited by 73 publications

(76 citation statements)

References 10 publications

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“…14,16,39 Our study demonstrated only a weak statistical association between tumor diameter and OS and only for tumors greater than 3 cm in diameter. This may be due to insufficient numbers as well as the inherent subjectivity involved in measurement of tumor diameter (calipers vs palpation, in vivo vs ex vivo, etc).…”

Section: Discussionmentioning

confidence: 54%

“…26 Although feline mammary carcinomas tend to be biologically aggressive, survival times can vary significantly. 19,29,36 Prognosis in affected cats has been shown previously to be influenced by tumor diameter, 14,16,36,38,39 World Health Organization (WHO) stage and modified WHO stage, 14,34 extent of surgery, 16,25 and histologic grade. 4,34 The Elston and Ellis (EE) histologic grading system (also known as the Nottingham Grading System) has been widely adopted by veterinary investigators for the grading of feline mammary carcinoma.…”

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confidence: 99%

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Prognostic Value of Histologic Grading for Feline Mammary Carcinoma

et al. 2014

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Feline mammary carcinoma is highly malignant and generally associated with a poor prognosis, although studies suggest the range of survival times in affected cats is broad. Histologic grading of these tumors is achieved using the Elston and Ellis system, originally developed for human breast cancer. In cats, however, classification using this method has variable prognostic value. Therefore, objectives of this study were (1) to evaluate the Elston and Ellis grading system for feline mammary carcinoma in a predominantly spayed population and (2) to determine whether modification of this system or development of a novel system improved the prognostic value of histologic grading. Survey data and histologic features for 108 carcinomas from 97 cats were analyzed with respect to overall survival. Elston and Ellis grading failed to correlate significantly with overall survival. Using multivariable analysis, lymphovascular invasion, nuclear form, and mitotic count each demonstrated independent prognostic significance (P ¼ .008, <.001, and .004, respectively). Modifications of the Elston and Ellis system and a novel grading system were proposed based on these results; all showed significant correlation with overall survival (P < .001). Median survival times were 27, 29, or 31 months for grade I; 14, 12, or 14 months for grade II; and 13, 5, or 8 months for grade III carcinomas using the mitotic-modified Elston and Ellis, the revised Elston and Ellis, or the novel grading system, respectively. Based on this retrospective study, adoption of the species-specific systems as proposed here may improve the prognostic value of histologic grading for feline mammary carcinoma.

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Section: Discussionmentioning

confidence: 54%

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confidence: 99%

Prognostic Value of Histologic Grading for Feline Mammary Carcinoma

et al. 2014

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“…The incidence of mammary tumors in cats is reduced by 91% in cats spayed prior to six months of age and by 86% in cats spayed prior to one year according to . Siamese cats and Japanese breeds seem to have increased risk (Ito et al, 1996) and obesity also appears to be a factor in tumor development (German, 2006). Malignant tumors make up 80 to 96% of mammary tumors in cats almost all adenocarcinomas (Millanta et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Surgical Approaches to Cat Breast Cancer (Mammary Tumor), their Treatment and Management at Richmond Crawford Veterinary Hospital Karachi (RCVH), Sindh, Pakistan.

2016

ARC Journal of Animal and Veterinary Sciences

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“…Il est alors nécessaire de connaître les facteurs pronostiques afin de prévenir le devenir du patient et de mettre en place un plan thérapeutique adapté. Ceux utilisés dans le pronostic du cancer du sein sont également connus dans l'espèce féline : la taille tumorale (MacEwen et al 1984 ;Ito et al 1996 ;Viste et al 2002 ;Millanta et al 2005 a;Seixas et al 2011), la présence ou non de métastases ganglionnaires ou à distance (Weijer et al 1983 ;Ito et al 1996 ;Seixas et al 2011, Zapulli et al 2014, le type et le grade histologique du carcinome (Weijer et al 1983 ;Ito et al 1996 ;Castagnaro et al 1998 ;Millanta et al 2002 ;Seixas et al 2011 ;Segonzac, 2013 ;Zapulli et al 2014), le caractère complet de l'exérèse chirurgicale (Weijer et al 1983), le score d'expression du facteur de croissance épidermique de type 2 (HER2) (Millanta et al 2005b ;Rasotto et al 2011), l'expression des récepteurs des oestrogènes et de la progestérone (Millanta et al 2005b ;Millanta et al 2006) et l'invasion lymphovasculaire (Seixas et al 2011 ;Preziosi et al 2002 ;Tanabe et al 2002 ;Sarli et al 2003;Zapulli et al 2014).…”

Section: Introductionunclassified

Emboles lymphatiques des carcinomes mammaires invasifs félins : amélioration de leur détection par immunohistochimie et valeur pronostique

Besnard¹

2016

bavf

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Notre étude rétrospective avec suivi clinique de 350 chattes a pour objectifs de déterminer la fréquence de l'embolisation lymphatique et sa corrélation avec les autres caractéristiques du carcinome mammaire invasif félin, de valider un marqueur immunohistochimique d'aide à la mise en évidence des emboles lymphatiques et de déterminer s'il améliore la prédiction pronostique. Nos résultats indiquent que l'invasion lymphovasculaire concerne 41% des carcinomes mammaires, notamment ceux de grande taille et/ou de haut grade et/ou négatifs pour le récepteur à la progestérone. L'embolisation lymphatique est un facteur pronostique fort lié au risque de généralisation métastatique et de décès lié au cancer. Dans près de 8% des cas, les coupes histologiques colorées par l'hémalun-éosine-safran (HES) ne permettent pas de statuer avec certitude sur sa présence. Le marqueur LMO2 (LIM-only domain protein-2), spécifique de l'endothélium lymphatique, permet de reclasser les cas douteux et participe à prédire le risque de décès des chattes à court terme après l'exérèse chirurgicale du carcinome. Mots

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Prognosis of Malignant Mammary Tumor in 53 Cats.

Cited by 73 publications

References 10 publications

Prognostic Value of Histologic Grading for Feline Mammary Carcinoma

Prognostic Value of Histologic Grading for Feline Mammary Carcinoma

Surgical Approaches to Cat Breast Cancer (Mammary Tumor), their Treatment and Management at Richmond Crawford Veterinary Hospital Karachi (RCVH), Sindh, Pakistan.

Emboles lymphatiques des carcinomes mammaires invasifs félins : amélioration de leur détection par immunohistochimie et valeur pronostique

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