Prognostic Value of Histologic Grading for Feline Mammary Carcinoma

Abstract

Feline mammary carcinoma is highly malignant and generally associated with a poor prognosis, although studies suggest the range of survival times in affected cats is broad. Histologic grading of these tumors is achieved using the Elston and Ellis system, originally developed for human breast cancer. In cats, however, classification using this method has variable prognostic value. Therefore, objectives of this study were (1) to evaluate the Elston and Ellis grading system for feline mammary carcinoma in a predominantly spayed population and (2) to determine whether modification of this system or development of a novel system improved the prognostic value of histologic grading. Survey data and histologic features for 108 carcinomas from 97 cats were analyzed with respect to overall survival. Elston and Ellis grading failed to correlate significantly with overall survival. Using multivariable analysis, lymphovascular invasion, nuclear form, and mitotic count each demonstrated independent prognostic significance (P ¼ .008, <.001, and .004, respectively). Modifications of the Elston and Ellis system and a novel grading system were proposed based on these results; all showed significant correlation with overall survival (P < .001). Median survival times were 27, 29, or 31 months for grade I; 14, 12, or 14 months for grade II; and 13, 5, or 8 months for grade III carcinomas using the mitotic-modified Elston and Ellis, the revised Elston and Ellis, or the novel grading system, respectively. Based on this retrospective study, adoption of the species-specific systems as proposed here may improve the prognostic value of histologic grading for feline mammary carcinoma.

Computerized Calculation of Mitotic Count Distribution in Canine Cutaneous Mast Cell Tumor Sections: Mitotic Count Is Area Dependent

“…Most grading systems as well as general recommendations request that mitotic figures should be counted in a single area comprised of 10 contiguous, non-overlapping hpf located in the tumor region with the highest mitotic activity. 6,13,14,20,25,29,31,33,42,45,46 A tumor section with an area of 4.0 cm 2 contains more than 1600 non-overlapping, standard-sized hpf.…”

Emboles lymphatiques des carcinomes mammaires invasifs félins : amélioration de leur détection par immunohistochimie et valeur pronostique

“…Actuellement recherchés uniquement sur coupes colorées par l'hémalun-éosine-safran (HES), ces emboles lymphatiques sont observés dans 37 à 70% des carcinomes mammaires félins selon les auteurs, avec une moyenne de 50% sur 804 cas (Millanta et al 2006, Seixas et al 2007Pohu, 2011 ;Mills et al 2015). Bien que peu étudiée, la valeur pronostique de l'embolisation lymphatique est démontrée d'une part en analyse univariée, de façon significative pour le risque de métastase à distance et celui de survie globale (Pohu, 2011 ;Segonzac, 2013) et d'autre part, de façon significative et indépendante pour la survie sans progression et la survie spécifique (Pohu, 2011, Seixas et al 2011Segonzac, 2013).…”

>b<Avaliação de marcadores imunohistoquímicos de resistência à múltiplas drogas nos carcinomas mamários em felinos>/b<

“…Esta proteína não apresentou qualquer associação significativa com nenhum dos parâmetros analisados. 68,9 (259,9 -530) SEIXAS et al, 2011;MILLS et al, 2015;DE CAMPOS et al, 2016). Mills et al (2015) relataram uma menor sobrevida em animais portadores de carcinomas dos subtipos sólidos ou cribiformes.…”

“…68,9 (259,9 -530) SEIXAS et al, 2011;MILLS et al, 2015;DE CAMPOS et al, 2016). Mills et al (2015) relataram uma menor sobrevida em animais portadores de carcinomas dos subtipos sólidos ou cribiformes. No presente estudo, foram identificados os subtipos túbulo-papilar, cribiforme e sólido, sem diferença significativa entre eles (P=0,323).…”

“…Nesta casuística, a maioria dos animais apresentou tumores com graus II e III (97,9%; P<0,001), indicando uma alta agressividade tumoral. A outra metodologia adotada foi desenvolvida especificamente para felinos, chamada aqui de metodologia de Mills (Mills et al, 2015). Da mesma forma, esta avaliação demonstrou que a maioria dos animais também apresentaram tumores com graduação II e III (82,6%; P=0,040).…”