2010
DOI: 10.1590/s0102-86502010000500014
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Abstract: Purpose:To evaluate and characterize the wound healing process profile induced by allantoin incorporated in soft lotion oil/water emulsion using the planimetric and histological methods. Methods: Female Wistar rats (n=60) were randomly assigned to 3 experimental groups: (C) control group-without treatment; (E) group treated with soft lotion O/W emulsion excipients; (EA) group treated with soft lotion O/W emulsion containing allantoin 5%. The emulsions either containing or not allantoin were topically administe… Show more

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Cited by 106 publications
(73 citation statements)
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References 18 publications
(15 reference statements)
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“…Until then, the methods used to evaluate the healing of these wounds evaluated at most only two dimensions (area) without assessing the depth [1][2][3][4][5][6][7][8][9][10][11][12] , which is the third dimension. The purpose of this study was to …”
Section: Discussionmentioning
confidence: 99%
“…Until then, the methods used to evaluate the healing of these wounds evaluated at most only two dimensions (area) without assessing the depth [1][2][3][4][5][6][7][8][9][10][11][12] , which is the third dimension. The purpose of this study was to …”
Section: Discussionmentioning
confidence: 99%
“…Acute wounds normally heal in an orderly and efficient manner characterized by distinct phases called hemostasis/inflammation, proliferation, and remodeling, which all overlap. Each healing phase depends on various factors such as tissue type, age, infections, health status, and, very importantly, nutritional status [20][21][22][23][24][25][26][27][28]. The first phase begins immediately after injury and is characterized by hemostasis and inflammation as a response to the injury.…”
Section: Wound and Wound Healingmentioning
confidence: 99%
“…It was shown that lesion dressing of chronic human wounds of various etiologies, with a patented mixture of four specific amino acids (AAs) needed for collagen synthesis [glycine (29,28 [58]. The rationale for treating wounds by hydrocolloidal medications enriched with the formulation of AA by providing the peculiar stoichiometric composition of the AA most contained in collagen was carefully discussed by the author [6].…”
Section: Nourishing Fibroblasts Based On Analysis Of Collagen Composimentioning
confidence: 99%
“…It is worthy to mention that SYM contains vitamin B 12 (EMA Assesement Report, 2009), which is uncommon for herbs, and allantoin. Vitamin B 12 is required for the red blood cell production (Blood is Yin) and allantoin stimulates the cell growth and proliferation (Yin) (Araújo et al, 2010;Ahn et al, 2013).…”
Section: Sym-symphitum Officinale Inu-inula Helenium (Radix) Cal-camentioning
confidence: 99%