Probiotics for treating eczema

Makrgeorgou, Areti; Leonardi‐Bee, Jo; Bath‐Hextall, Fiona; Murrell, Dédée F.; Tang, Mimi L.K.; Roberts, Amanda; Boyle, Robert

doi:10.1002/14651858.cd006135.pub3

Cited by 81 publications

(84 citation statements)

References 167 publications

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“…Once AD is established, however, such dietary supplementation confers no additional benefit in treatment. [95][96][97] The mechanism underpinning this likely involves the microbial gut-skin axis and immunomodulatory components produced by certain bacterial strains, as discussed below. The evidence for prebiotics (oligosaccharides) appears promising, although limited in follow-up duration.…”

Section: Gut Microbiome and Dietary Influencesmentioning

confidence: 99%

The exposome in atopic dermatitis

Stefanovic

Flohr

Irvine

2019

Allergy

128

103

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Atopic dermatitis (AD) (syn. atopic eczema) is a chronic inflammatory skin condition, affecting up to 20% of children and 5%-10% of adults. 1,2 Current understanding of AD pathogenesis points towards a sophisticated interplay between genetic and environmental factors. The pathogenesis of AD may start in many cases with a genetically predetermined skin barrier defect, which manifests itself as dry skin. This inherent skin barrier deficit leads to an overexpression of pro-inflammatory cytokines and subsequently the activation of innate lymphocyte subsets and antigen-presenting cells (T H 2 and T H 22). IL-4 and IL-13 in particular drive eosinophil and mast cell recruitment and IL-31 secretion, a key cytokine involved in itch sensation. 3 Transcutaneous sensitization to environmental allergens and bacterial infections, in particular Staphylococcus aureus, further contributes to the barrier disruption and eczematous skin inflammation. While a genetic barrier defect is present in many, this is not a prerequisite and many pathological pathways can lead to AD. There

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Section: Gut Microbiome and Dietary Influencesmentioning

confidence: 99%

The exposome in atopic dermatitis

Stefanovic

Flohr

Irvine

2019

Allergy

128

103

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“…Although probiotics are safe and are used as a reasonable option of dermatitis preventive treatment in under-6-month children or high-risk pregnant women, their impact on active treatment appears to be reduced. 59,60 However, in order to apply this recommendation, solving several practical questions that currently do not have an answer is necessary, for instance: Does the type of microbiota affect the impact of probiotics? What dosage?…”

Section: Is the Use Of Probiotics In Atopic Dermatitis Useful?mentioning

confidence: 99%

Systematic review about 10 interventions in dermatitis. A document from the Latin American Society of Allergy, Asthma, and Immunology

Sánchez

Sánchez²,

Macías-Weinmann

et al. 2019

RAM

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The Latin American Society of Allergy, Asthma, and Immunology (SLAAI) conducted a systematic search in the Medline and LILACS' database in order to get articles linked to 10 current questions about dermatitis. The assessment of the quality of the evidence and the strength of the recommendations was made through the GRADE system. The completeness and transparency of the recommendations for this clinical guide were assessed with the AGREE Reports Verification Checklist. The final document was shared with physicians, allergists, dermatologists, and pediatricians, and with patients and academic institutions such as universities and medical scientific societies for external assessment. According to the review, clinical scales should be used to measure the severity of the dermatitis, and some interventions such as the use of probiotics may benefit the patient; nevertheless, more studies are required before this management option can be used in the everyday practice. Other interventions such as dietary restrictions and the use of antihistamines seem to be well-founded only in particular cases and they should not be a general recommendation for all patients. This practical guide presents recommendations for the treatment of atopic dermatitis; these recommendations can be helpful for medical staff, patients, and health systems.

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“…There are numerous reports in the literature of a compromised molecular composition in the epidermis of individuals with AD, especially in a protein critical for the integrity of the stratum corneum -filaggrin [19] . However, most of the studies conducted on the efficacy of this strategy have been based only on improved scoring rates of lesions in the form of eczema [20] , which is perhaps behind the poor correlations found between the use of probiotics and improvements in skin health. There are different methods to evaluate skin barrier function in vivo as a quantitative parameter applied to the characterization of the evolution of cutaneous pathologies.…”

Section: Discussão E Conclusãomentioning

confidence: 99%

“…In the present study, the comparison between the mean values obtained in the present study of TEWL, erythema quantified by colorimetry (a *) and LDF allows us terapêuticas, sendo uma das mais recentes a intervenção por suplementação com probióticos. Encontram-se inúmeros relatos na literatura de uma composição molecular comprometida na epiderme de indivíduos com DA, especialmente numa proteína crítica para a integridade da barreira do estrato córneo-a filagrina [19] .No entanto, a maioria dos estudos realizados sobre a eficácia desta estratégia tem sido baseada apenas na melhoria de índices de scoring das lesões sob a forma de eczema [20] , o que talvez esteja por trás das pobres correlações encontradas entre o uso de probióticos e melhorias da saúde cutânea. Existem diferentes métodos para avaliar in vivo a função de barreira da pele como parâmetro quantitativo aplicado à caracterização da evolução de patologias cutâneas.…”

Section: Discussão E Conclusãounclassified