Determination of relevant endpoints to evaluate the in vivo barrier function in cutaneous health

Alves, Emília; Rijo, Patrícia; Rodrigues, Luís Monteiro; Rosado, Catarina

doi:10.19277/bbr.16.1.201

Cited by 1 publication

(4 citation statements)

References 23 publications

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“…An innovative note in our approach is the use of the SLS irritation induction model to further demonstrate the beneficial impact of kefir consumption in barrier function in healthy skin. These results are supported by previous research by the authors [63]. Other studies using similar approaches but conducted in animal models exposed to irritants (ex vivo and in vivo) observed a decrease in TEWL after ingesting probiotics [83,84].…”

Section: Discussionsupporting

confidence: 90%

“…The skin condition was quantitatively evaluated by non-invasive bioengineering equipment, including those assessing TEWL, SC hydration, and erythema, which is a sign of exacerbation in AD [60][61][62]. TEWL, a measure of the rate of water lost through the skin, reflects barrier dysfunction directly, thus being a parameter of interest to evaluate skin barrier function in both healthy and diseased skin [60,63]. It was measured using a Tewameter ® TM300 (Courage + Khazaka Electronic GmbH, Köln, Germany) in accordance with the published guidelines [64], and measurements were expressed as g/m 2 /h.…”

Section: Skin Measurementsmentioning

confidence: 99%

“…As shown in a previous study, the use of a stress test to assess the skin barrier function after a probiotic intervention represents a novel approach in this field [63]. Therefore, a sodium lauryl sulfate (SLS)-induced skin lesion model was applied at baseline (t0) and after the intervention period (t8).…”

Section: Skin Measurementsmentioning

confidence: 99%

“…This test, consisting of the application of a 1% solution of SLS under occlusion for 24 h, was conducted in the forearm and only on volunteers with healthy skin, as the application of SLS would be detrimental to the volunteers in the atopic group, potentially causing excessive discomfort. The extent of the impact of SLS was assessed by evaluation of TEWL combined with measurement of erythema as described elsewhere [63] using a Chroma Meter ® CR300 (Konica Minolta, Tokyo, Japan) and expressed as a* in the L*a*b* system color [66].…”

Section: Skin Measurementsmentioning

confidence: 99%

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Homemade Kefir Consumption Improves Skin Condition—A Study Conducted in Healthy and Atopic Volunteers

Alves

Gregório

Baby

et al. 2021

Foods

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Diet has a fundamental role in the homeostasis of bodily functions, including the skin, which, as an essential protective barrier, plays a crucial role in this balance. The skin and intestine appear to share a series of indirect metabolic pathways, in a dual relationship known as the “gut-skin axis”. Hence, the gut-skin axis might be receptive to modulation via dietary modification, where probiotics can be included, thus representing a potential therapeutic target in inflammatory skin diseases, such as atopic dermatitis (AD), in order to control and/or ameliorate symptoms. Kefir is one of the most ancient fermented foods, with probiotic characteristics that have been associated with a wide variety of health-promoting benefits, and it presents a microbiological diversity that makes its application as a probiotic in the gut-skin relationship of the utmost interest. However, the impact of a diet containing kefir on skin health has yet to be reported in scientific literature. This study aimed to assess the impact of the intake of homemade kefir in the skin of healthy and atopic volunteers. The intervention resulted in a boost on barrier function in both skin types verified only in the respective kefir intake groups. An improvement in the degree of severity of AD was also confirmed for the kefir intake group. Atopic individuals may benefit from kefir intake, especially in regard to their skin hydration. Finally, the effects observed on skin barrier function in this study probably culminate from the effects of all the ingredients in kefir, including the complex microbiota, its metabolites and macro- and micronutrients resulting from the fermentation. This work opens the way for more advanced research on the impact of the probiotic kefir on cutaneous health, further clarifying its mechanism of action namely via gut-skin axis.

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Section: Discussionsupporting

confidence: 90%