Primary ocular sarcomas in the cat

Abstract

Primary ocular sarcomas were diagnosed following enucleation (1 2) or necropsy (one) in 13 cats over an eight year period. Twelve of the 13 cats were males; ages of affected animals were seven to 15 years, with a mean of 12. Five of the cats had a history of previous trauma and six others had a history of chronic uveitis. Morphologically the neoplasm was comprised of undifferentiated spindle cells and appeared to arise in the anterior uvea. The cancer was quite aggressive, with extension into adjacent tissues and/or distant metastases commonly encountered. Seven of 12 cats experienced confirmed tumour related deaths within months following enucleation and one was humanely destroyed at the time of original presentation.

Ocular Tumors

“…[49][50][51][52] In the COPLOW collection, 8% of feline ocular tumors are posttraumatic sarcoma. [49][50][51][52] In the COPLOW collection, 8% of feline ocular tumors are posttraumatic sarcoma.…”

“…[49][50][51][52] In the COPLOW collection, 8% of feline ocular tumors are posttraumatic sarcoma. [49][50][51] Because of the risk of posttraumatic sarcoma, many clinicians are cautious about cataract surgery or the use of an intrascleral prosthesis in cats. All three have similar histories leading up to tumor presentation.…”

“…All three have similar histories leading up to tumor presentation. [49][50][51] These tumors, often within the same eye, exhibit a spectrum of changes ranging from granulation tissue to fibrosarcoma, osteosarcoma, and anaplastic spindle cell sarcoma. Damage to the lens and chronic uveitis may be risk factors.…”

“…53 Chronic inflammation may support neoplastic transformation of a pluripotent cell. 49,52 Further support for this approach comes from the observation that approximately 8% of globes removed prophylactically in the COPLOW collection already have tumors. 50,51 All of these tumors tend to circumferentially line the choroid and quickly infiltrate the retina and optic nerve.…”

Feline injection site‐associated sarcomas

“…Development of feline sarcomas secondary to inflammation has been described in a variety of organs, including the eye following trauma or uveitis (Peiffer and others 1988), uterus following pyometra (Jelíneka 2003) and muscle or skin following placement of non-absorbable suture or microchips (Buracco and others 2002). The first reports of feline injection site-associated sarcomas (FISS) were published in 1991 (Hendrick and Goldschmidt 1991), after Pennsylvanian law required cats to receive rabies vaccination.…”