Ocular Tumors

Intraocular signet‐ring cell melanoma in a hamster (Cricetulus griseus)

“…However, there is insufficient data in the hamster. In dogs, the prognosis for histologically benign melanomas appears to be excellent, but the predilection for the anterior uvea frequently results in glaucoma 10,44 . Enucleation is curative.…”

“…Enucleation is curative. Attempts at local excision or laser photoablation may be only palliative, especially if the ciliary body or trabecular meshwork is involved 44–46 . The presence of black, nonsolid material within the orbit following the enucleation of benign melanomas with scleral invasion apparently does not affect prognosis, because these cells and pigment debris appear incapable of continued growth 44 .…”

“…Attempts at local excision or laser photoablation may be only palliative, especially if the ciliary body or trabecular meshwork is involved 44–46 . The presence of black, nonsolid material within the orbit following the enucleation of benign melanomas with scleral invasion apparently does not affect prognosis, because these cells and pigment debris appear incapable of continued growth 44 . In the malignant form of uveal melanoma in the cats, the rate of metastasis (frequently to the liver and lungs) has been reported to vary from 55% to 66% or higher 44,47,48 .…”

“…The presence of black, nonsolid material within the orbit following the enucleation of benign melanomas with scleral invasion apparently does not affect prognosis, because these cells and pigment debris appear incapable of continued growth 44 . In the malignant form of uveal melanoma in the cats, the rate of metastasis (frequently to the liver and lungs) has been reported to vary from 55% to 66% or higher 44,47,48 . Because the tumor is relatively slow growing, however, the period until metastatic disease becomes apparent may be measured in years.…”

“…Because the tumor is relatively slow growing, however, the period until metastatic disease becomes apparent may be measured in years. Enucleation after the tumor has invaded into the ciliary body but not the sclera warrants a poorer prognosis, but median survival time is still approximately 5 years 44,49 . Enucleation after the tumor has invaded into the ciliary body and the sclera merits an even poorer prognosis, with a median survival time of approximately 1.5 years.…”