Tumors of the Cornea and Sclera

Fischer, Craig A.; Lindley, Denise M.; Carlton, William C.; Hecke, Holly Vank

doi:10.1002/9780470376904.ch5

Cited by 14 publications

(44 citation statements)

References 58 publications

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“…Squamous cell carcinoma was the predominant type of eyelid neoplasm in cattle, cats and sheep while melanocytic tumors are commonly seen in dogs [1][2][3][4][5][6][7]. Ocular fi brosarcomas may develop in the orbit of cats with pthysis bulbi, ocular trauma or ocular foreign bodies [8].…”

Section: Introductionmentioning

confidence: 99%

Retrobulbar Fibrosarcoma in a Sheep

et al. 2016

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This report describes a case of a retrobulbar fi brosarcoma in a 4-year-old female sheep. A big tumor was protruding from the orbit but not invading the surrounding tissue and was easily removed surgically. The grayish colored mass was 19x13x8 cm in size and hard. The surface of the tumor was irregular and ulcerated. Marked hemorrhage and necrotic areas were present across the whitish cut surface. Histopathologically, the mass was composed of spindle shaped, anaplastic pleomorphic cells. Masson's trichrome staining revealed a collagenous matrix in the tissue. Immunohistochemically, the mass was positive for vimentin and proliferating cell nuclear antigen but negative for smooth muscle actin, desmin, glial fi brilar acidic protein and S100 protein antibodies. According to histopathological and immunohistochemical fi ndings the tumor was diagnosed as fi brosarcoma. To the authors' knowledge, this is the fi rst report of ocular fi brosarcoma in a sheep.

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Section: Introductionmentioning

confidence: 99%

Retrobulbar Fibrosarcoma in a Sheep

et al. 2016

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“…Primary corneal squamous cell carcinoma (SCC) is considered rare in dogs [1,2], indeed, until 2008, only four cases of this type of tumor had been described [5,6]. Nevertheless, in the last two years, some case reports (n = 6) [7][8][9][10] and a case series (n = 26) [11] of canine primary corneal SCC have been published, and occurrence of this type of tumor seems to be increasing [11].…”

Section: Discussionmentioning

confidence: 99%

“…Neoplasms of the cornea occur uncommonly in dogs although various primary and secondary tumors have been described in veterinary literature [1,2]. Corneal squamous cell carcinoma (SCC) is considered rare in the dog and often represents a secondary extension of a primary limbal or conjunctival neoplasia [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Corneal squamous cell carcinoma (SCC) is considered rare in the dog and often represents a secondary extension of a primary limbal or conjunctival neoplasia [1,3,4]. A number of cases of canine primary SCC of the cornea have been described especially in recent years [5][6][7][8][9][10], and some authors report an increased occurrence of the tumor in this period [11].…”

Section: Introductionmentioning

confidence: 99%

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Primary Corneal Squamous Cell Carcinoma in a Dog: Clinical and Histopathological Evaluation

Barsotti

Ressel

Finotello

et al. 2012

Case Reports in Veterinary Medicine

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An 8-year-old male pug with a 12-month history of a progressive nonpainful mass on the left cornea was evaluated. Ocular examination showed a severe bilateral keratoconjunctivitis sicca, pigmentary keratitis, and an exophytic irregular pink mass occupying approximately 75% of the total corneal surface of the left eye. A squamous cell carcinoma (SCC) was suspected on cytology, and clinical investigations showed no evidence of metastases. A transpalpebral enucleation was therefore performed, and the diagnosis of SCC was confirmed on histopathology. Immunohistochemical investigations showed that the neoplastic cells were pan-cytokeratin positive and vimentin negative. Additionally, nuclei immunoreactive to Ki-67 antigen were detected. Tumor cells were also negative to p53. Immunoreactivity to COX-2 was found in less than 10% of the neoplastic cells. No adjuvant therapies were instituted, and no evidence of local recurrence or distance metastasis was identified during the 24-month follow-up period.

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“…1984; Giuliano 2010). Equine ocular and periocular SCC is typically invasive, resulting in discomfort and blindness if untreated (Fischer et al . 2002).…”

Section: Introductionmentioning

confidence: 99%

Delayed metastasis of ocular squamous cell carcinoma following treatment in five horses

Mair

Sherlock

Pearson

2012

Equine Veterinary Education

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SummaryIdentification of regional and/or distant metastasis following treatment and local resolution of primary ocular squamous cell carcinoma (SCC) was observed in 5 horses. In all cases, identification of metastasis occurred at least 18 months following treatment of the primary ocular lesions. In 3 cases, invasion of blood or lymphatic vessels by neoplastic cells was identified in the excisional biopsies of the primary tumour. Two horses developed SCC at 2 or more separate sites. At the time metastases were identified, there was no evidence of local recurrence of the ocular tumour in any of the horses. These cases confirm the importance of long-term monitoring of horses for metastatic disease following treatment of ocular SCC even in the absence of local recurrence.

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Tumors of the Cornea and Sclera

Cited by 14 publications

References 58 publications

Retrobulbar Fibrosarcoma in a Sheep

Retrobulbar Fibrosarcoma in a Sheep

Primary Corneal Squamous Cell Carcinoma in a Dog: Clinical and Histopathological Evaluation

Delayed metastasis of ocular squamous cell carcinoma following treatment in five horses

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