Feline injection site‐associated sarcomas

Bowlt, Kelly

doi:10.1136/inp.h65

Cited by 5 publications

(13 citation statements)

References 49 publications

(85 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…9 In contrast to the large number of studies in humans and dogs, 10,11 thermographic assessment of feline neoplastic diseases, including feline injection site sarcoma (FISS; a malignant mesenchymal tumor developing at sites of injection of vaccines and other products), has seldom been reported. 12 This study set out to determine the average temperature of feline skin and soft tissue tumors, and to investigate correlations between thermographic findings and histologic diagnosis following surgical resection. Correlations between tumor temperature, tumor grade and histologic subtype were also investigated in cases of FISS.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thermographic assessment of skin and soft tissue tumors in cats

Nitrini

Cogliati

Matera

2020

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

Objectives This study set out to determine the average temperature of skin and soft tissue tumors in cats using infrared thermography and to investigate correlations between thermographic findings and tumor type. Correlations between thermographic findings, histologic subtype and tumor grade were also investigated in cases of feline injection site sarcoma (FISS). Methods Thermographic images of normal skin and skin overlying neoplastic lesions were prospectively obtained. Following thermographic assessment, tumors were resected and submitted to histopathologic and immunohistochemical analysis. Mean temperatures detected in tumoral areas were compared between different tumor types and between FISSs of different histologic subtypes and grades. Results Thermograms obtained from 11 healthy cats and 31 cats presenting with skin and soft tissue tumors (eight benign and 23 malignant tumors, including 21 FISSs) were evaluated in this study. Thermal behavior varied widely in normal skin, as well as in skin overlying neoplastic lesions. Mean temperatures were significantly higher in malignant compared with benign tumors (35.4 ± 1.8ºC and 34.5 ± 1.7ºC respectively; P = 0.01), with a temperature above 34.7ºC being associated with malignancy (sensitivity 76%, specificity 80%; P = 0.01). Temperatures detected in FISS did not differ significantly according to histologic subtype ( P = 0.91) or tumor grade ( P = 0.46), or between primary and recurring tumors ( P = 0.25). Conclusions and relevance Infrared thermography proved to be a sensitive and effective method for detection of temperature differences between malignant and benign skin and soft tissue tumors in cats. Thermographic assessment may contribute to diagnosis and prognostic estimation in feline oncologic patients.

show abstract

Section: Introductionmentioning

confidence: 99%

“…In contrast to the large number of studies in humans and dogs, 10,11 thermographic assessment of feline neoplastic diseases, including feline injection site sarcoma (FISS; a malignant mesenchymal tumor developing at sites of injection of vaccines and other products), has seldom been reported. 12…”

Section: Introductionmentioning

confidence: 99%

Thermographic assessment of skin and soft tissue tumors in cats

Nitrini

Cogliati

Matera

2020

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

show abstract

“…FISAS cells have histological characteristics that are distinct from those of other spontaneously arising fibrosarcomas, such as perivascular infiltration of lymphocytes and macrophages at the periphery of the tumor, a central area of necrosis, high mitotic index, severe cellular pleomorphism, and granulation tissue at the periphery . These tumors are very challenging to treat, as they grow rapidly and invade surrounding tissues . Although distant metastasis affects 20%‐28% of cats with FISAS, local recurrence of the tumor is the greatest cause of mortality, reported in 14%‐45% of cats following complete excision and up to 70% of cats after incomplete excision of the tumor .…”

Section: Introductionmentioning

confidence: 99%

“…These tumors are very challenging to treat, as they grow rapidly and invade surrounding tissues . Although distant metastasis affects 20%‐28% of cats with FISAS, local recurrence of the tumor is the greatest cause of mortality, reported in 14%‐45% of cats following complete excision and up to 70% of cats after incomplete excision of the tumor . Radical surgical excision of the tumor offers the best prognosis, but often requires thoracic or abdominal wall excision, amputation, or hemipelvectomy, or removal of the scapula or dorsal spinous processes .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro chemosensitivity of feline injection site‐associated sarcoma cell lines to carboplatin

et al. 2017

View full text Add to dashboard Cite

show abstract

Feline injection site sarcomas

Nobrega¹,

Mesquita²,

Cruz³

et al. 2016

The Veterinary Nurse

View full text Add to dashboard Cite

Feline injection site sarcoma (FISS), formerly known as vaccine associated sarcoma (VAS), is a rare but life-threatening disease. The incidence estimates have varied from one case of FISS per 1000–10 000 cats vaccinated in North America and between one per 5000–12 500 vaccination visits in UK. It has been primarily associated with vaccine administration, but several other injectable materials/substances have been implicated as aetiologic agents, namely lufenuron, penicilin, metilprednisolone, meloxicam, non-absorbable suture material and microchip. FISS can have a long latency period (3 months to 13 years), but 8 years old is the average age of onset. FISS are tumours that arise subcutaneously, reaching a variable number of layers beneath the skin (muscle, bone). They are firm, not painful, solid and variable in size. Clinical assessment and biopsy are the basis for FISS diagnosis. In order to prevent FISS, vaccination should be carefully planned and be provided in easily resectable regions. Hind legs, tail and flanks, are preferable regions for vaccine administration.

show abstract

Feline injection site‐associated sarcomas

Abstract: Feline injection site-associated sarcomas were first reported in 1991. They are reported to affect between 0.63 and 13 cats per 10,000. This article discusses the clinical presentation and diagnosis of feline injection site-associated sarcomas, along with current approaches to treatment.

Cited by 5 publications

References 49 publications

Thermographic assessment of skin and soft tissue tumors in cats

Thermographic assessment of skin and soft tissue tumors in cats

In vitro chemosensitivity of feline injection site‐associated sarcoma cell lines to carboplatin

Feline injection site sarcomas

Contact Info

Product

Resources

About