Primary Neoplasms of the Hair Follicle

Headington, John T.; French, Arthur B.

doi:10.1001/archderm.1962.01590100044012

Cited by 162 publications

(57 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…10 Trichoepithelioma (TE) is a benign, cutaneous mesenchymal tumor originating from germ layer of hair follicle. [11][12][13] Trichoblastoma (TB) is extremely rare benign tumors located deep dermis and subcutis. 14 It is frequently seen on head and neck 3,15 and mostly sized less than 1 cm in diameter.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

Şengül¹

2011

UHOD

View full text Add to dashboard Cite

Differential diagnosis between benign tumors of cutaneous appandages originating from hair follicle (BTCOHF) (trichoadenoma [TA], trichofolliculoma [TF], trichoepithelioma [TE] and trichoblastoma [TB]) and basal cell carcinoma (BCC) have been tedious for the pathologists, especially in the presence of small specimens to date. Thirty cases of BTCOHF and 30 cases of BCC were retrieved from the archives, deposited from 2004 to 2008. Age, sex, localisation and histopathological characters such as ulceration, pigmentation, inflammation, and cyst formation were comparatively evaluated between both groups and each subgroups. No significant diference was detetected between two groups in the rate of the age, sex and the histopathology. Besides, histopathological characters were not significant for the subgroups of BCC. However, ulceration was observed in TE (Of 21 cases 5, [23.8%]) and TB (All the 5 cases, [100%]), but not in TA and TF which are the subgroups of BTCOHF and the difference was significant (p= 0,005). But, pigmentation, inflammation and cyst formation were not significant among the subgroups of both groups. We can conclude that BCC and BTCOHF may not be discriminated concerning age, sex and histopathological characters including ulceration, pigmentation, inflammation, and cyst formation. Secondly, one may not make the differential diagnosis easily even between the subgroups of each group via evaluating the histopathological characters, so that might create some life-threatening unwelcome outcomes. Keywords: Basal cell carcinoma, Pigmentation, Inflammation, Histopathology ÖZET Histopatolojik karakterler Bazal Hücreli Karsinoma ile K›l Follikülünden Köken Alan Benign Deri Eki Tümörlerinin Ay›r›c› Tan›s›nda Yararl› OlamayabilirTrikoadenoma, trikofolliküloma, trikoepitelyoma ve trikoblastoman›n bazal hücreli karsinomadan ay›r›c› tan›s›, bugüne kadar özellikle küçük spesimenlerde patologlar için can s›k›c› ve usand›r›c› olmaya devam edegelmifltir. Otuz k›l follikülünden köken alan benign deri eki tümörleri olgusu ve 30 bazal hücreli karsinoma olgusu, 2004 -2008 y›llar› aras›nda depoland›¤› arflivden yeniden edinildi. Yafl, cinsiyet, lokalizasyon ve ülserasyon, pigmentasyon, inflamasyon ve kist formasyonu gibi histopatolojik karekterler her iki grup ve her subgrup aras›nda karfl›laflt›rmal› olarak de¤erlendirildi. Yafl, cinsiyet, lokalizasyon ve histopatoloji aç›s›ndan iki grup aras›nda anlaml› fark saptanmad›. Ayr›ca, histopatolojik karekterler bazal hücreli karsinoman›n subgruplar› için anlaml› de¤ildi. Bununla birlikte; ülse-rasyon, k›l follikülünden köken alan benign deri eki tümörlerinin subgruplar› olan trikoepitelyoma (21 olgunun 5'inde [%23.8]) ve trikoblastomada (5 olgunun tümünde [%100]) izlendi, ancak trikoadenoma ve trikofollikülomada izlenmedi ve bu fark anlaml› bulundu (p= 0.005). Pigmentasyon, inflamasyon ve kist formasyonu her iki grubun subgruplar› aras›nda anlaml› de¤ildi.

show abstract

Section: Introductionmentioning

confidence: 99%

“…2 Although all they are benign, their aggressive forms resemble basal cell carcinoma (BCC) 11 and potentially tend to metastasize. [16][17][18] BCC is the most common malignancy worldwide in white people 19 and accounts for 65-75% of all skin tumors.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

Şengül¹

2011

UHOD

View full text Add to dashboard Cite

show abstract

“…Neoplasias com diferenciação em estruturas semelhantes a pêlos ou a porções dos pêlos incluem tricoepitelioma, tricofoliculoma, pilomatricoma, epitelioma intracutâneo cornificante (WALDER & GROSS, 1992), carcinoma tricolemal, tumor tricolemal proliferante e tricoadenoma, sendo os três últimos só descritos no homem (LEVER & SCHAUMBURG-LEVER, 1983;HEADINGTON, 1976 STARNNARD, 1990;WEISS & FRESE, 1974). Em decorrência, considera-se necessária uma breve discussão com relação à aparência histológica desses tumores.…”

Section: Discussionunclassified

“…Alguns desses lóbulos apresentam organização estrutural semelhante à do tricolemoma, podendo ser diferenciado, basicamente, pelo tipo celular, já que o aparecimento de células claras nesse tumor é ocasional. Queratinização abrupta e calcificação no centro dos lóbulos são pontos importantes para o diagnóstico (LEVER & SCHAUMBURG-LEVER, 1983;HEADINGTON, 1976). O tricoadenoma é formado por numerosos cistos córneos cuja parede é composta por células epiteliais eosinofílicas; algumas ilhas são constituí-das inteiramente por essas células.…”

Section: Discussionunclassified

“…Os tumores primários do folículo piloso podem ter duas origens, a matriz do pêlo, de onde formam-se neoplasias que são subclassificadas de acordo com o grau de diferenciação morfológica, e a bainha externa do pêlo, constituída por células claras, que formam os tricolemomas (HEADINGTON & FRENCH, 1962). Essa neoplasia foi primeiramente descrita no homem, acometendo indivíduos entre 30 e 90 anos (HEADINGTON, 1976), preferencialmente do sexo feminino; localizase tipicamente na face (GOLDMAN & RICHFIELD, 1977) e mede menos de 1cm, podendo ser solitária ou múltipla (LEVER & SCHAUMBURG-LEVER, 1983). Na literatura veterinária, existem apenas duas referências a esses tumores, ambas na espécie canina.…”

Section: Introductionunclassified

See 1 more Smart Citation