Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

Şengül, İlker

doi:10.4999/uhod.10044

Cited by 15 publications

(31 citation statements)

References 32 publications

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“…The immunostaining fashion of CK5/6, CK14 and P63 which were not present in trichoblastoma also support this point of view. Admittedly, there are some similarities between trichogerminoma and trichoblastoma, including the profile of Bcl-2 and CD10 expression [9-11]. Reviewing all the cases previously reported and our two cases, we come to a conclusion that maybe trichogerminoma should be an independent concept, as a histological subtype of trichoblastoma, since they have basic common features and distinct differences.…”

Section: Discussionmentioning

confidence: 68%

Trichogerminoma, a rare cutaneous follicular neoplasm with indolent clinical course: report of two cases and review of literature

Chen

2013

Diagn Pathol

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Trichogerminoma is a rare cutaneous adnexal neoplasm of the hair germ cell and usually associated with benign clinical course and favorable outcome. Since its first description by Sau et al. in 1992, only a few cases have been reported up to date. Herein, we report two additional cases occurring in the hip and right thigh, respectively. Both patients are male, one is 78 years old, the other is 29 years old. Histological examination reveals well-circumscribed dermal nodule composed of lobules of basaloid cells with surrounding pseudocapsule. The distinct characteristic of the tumor is that most of the lobules display a special pattern of round nests or cell balls arranged in the central part with the peripheral palisading. Immunostaining showed ring-like fashion of CK5/6, P63 and Bcl-2 with negative or weak staining in the “cell balls”. There was no recurrence after complete excision during the period of follow-up. To the best of our knowledge, this is the first report of trichogerminoma in Chinese population. In contrast to the previously reported cases, ours present the similar morphological features with distinct immunohistochemical characteristics. We consider the concept of trichogerminoma exists with no doubt by its identifiable morphological features, and it should be classified as a variant of trichoblastoma. Because of its malignant potential, complete excision is a prior choice of treatment for this rare but distinctive tumor.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1558612241110439.

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Section: Discussionmentioning

confidence: 68%

Trichogerminoma, a rare cutaneous follicular neoplasm with indolent clinical course: report of two cases and review of literature

Chen

2013

Diagn Pathol

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“…Several attempts have been made to differentiate these two entities using different markers . Currently, the most widely used marker to differentiate these two diagnoses is PHLDA1 .…”

Section: Discussionmentioning

confidence: 99%

Vismodegib induces significant clinical response in locally advanced trichoblastic carcinoma

et al. 2015

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Patients with advanced basal cell carcinoma due to local extension or metastatic disease were previously at a therapeutic impasse. Targeted inhibition of the sonic hedgehog pathway by vismodegib represents a new therapeutic strategy. Adnexal carcinomas are rare malignant skin tumours derived from epithelial annexes. Conventional treatment of adnexal tumours is based on surgical excision. Although the radiosensitivity of adnexal carcinomas has not been established, radiotherapy could be offered alone or in combination in locally advanced or inoperable disease. Chemotherapy represents a therapeutic option in the treatment of metastatic adnexal tumours. Currently there is no effective treatment for these tumours when they become metastatic or unresectable, and treatment is palliative. Sunitinib represents a new therapeutic strategy, with efficiency described in the literature for a small number of patients. However, its efficacy is partial, and its tolerance is not always good. We report a patient with trichoblastic carcinoma, initially diagnosed as basal cell carcinoma, treated effectively with vismodegib. The remarkable response we have observed in this patient suggests an encouraging therapeutic role of vismodegib in trichoblastic carcinoma that should be evaluated in a carefully designed trial.

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“…Immunohistochemistry markers podoplanin (d2‐40), follicular stem cell marker PHLDA1 (TDAG51), and CD10 may be useful in differentiating between TE and BCC in small biopsy specimens . Routine histology with clinical correlation is considered as the gold standard for distinguishing TE from BCC.…”

Section: Discussionmentioning

confidence: 99%

The clinicopathological spectrum of trichoepitheliomas: a retrospective descriptive study

et al. 2015

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Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

Cited by 15 publications

References 32 publications

Trichogerminoma, a rare cutaneous follicular neoplasm with indolent clinical course: report of two cases and review of literature

Trichogerminoma, a rare cutaneous follicular neoplasm with indolent clinical course: report of two cases and review of literature

Vismodegib induces significant clinical response in locally advanced trichoblastic carcinoma

The clinicopathological spectrum of trichoepitheliomas: a retrospective descriptive study

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