Trichilemmoma. Analysis of 40 new cases

Brownstein, Martin H.

doi:10.1001/archderm.107.6.866

Cited by 46 publications

(34 citation statements)

References 12 publications

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“…The most common type occurs as a small, warty or smooth, skin-colored papule on the face of middle-aged or older people, generally misdiagnosed as a verrucous papilloma. Rarely does it correspond to a cutaneous horn [2]. Multiple tricholemmomas are associated with Cowden syndrome which results from a mutation in the phosphatase and tensin homolog tumor suppressor gene, PTEN [3].…”

Section: Discussionmentioning

confidence: 99%

A Case of Solitary Tricholemmoma

Hong-pu¹,

Liang²

2017

JCDSA

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Section: Discussionmentioning

confidence: 99%

A Case of Solitary Tricholemmoma

Hong-pu¹,

Liang²

2017

JCDSA

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“…Because the morphological features are reminiscent of the follicular outer root sheath, the lesions were introduced in the literature as follicular tumors. [40][41][42][43][44] Desmoplastic trichilemmomas contain an area of thin tumor strands embedded within a hyalinized stroma, often incorrectly precipitating the impression of stromal invasion. 45,46 Because of the morphological resemblance of trichilemmomas to old warts, manifested by the verrucous surface and the wedge-shaped hypergranulosis, the possibility of HPV as a major factor in the pathogenesis of these lesions was raised by Ackerman in 1978.…”

Section: Discussionmentioning

confidence: 99%

p16 Expression in Conventional and Desmoplastic Trichilemmomas

Hilliard

Wakefield²,

Krahl³

et al. 2009

The American Journal of Dermatopathology

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The expression of p16 in cutaneous neoplasms is upregulated in melanocytic neoplasms, ultraviolet radiation-induced neoplasms, such as actinic keratoses and squamous cell carcinomas, and in lesions related to human papillomavirus, such as Bowen's disease and bowenoid papulosis. In cervical dysplasia and tonsillar carcinoma, there is such a close relationship between p16 and human papillomavirus (HPV) to the extent that p16 immunostaining is used as a surrogate marker for the presence of HPV proteins. In this study we were interested in the expression pattern of p16 in trichilemmomas. Twenty-six conventional and 19 desmoplastic trichilemmomas were immunohistochemically stained for p16. p16 immunostaining was noted in the majority of conventional (80.8%) and desmoplastic trichilemmomas (73.7%). The staining pattern was both nuclear and cytoplasmic. The staining intensity was more pronounced in the desmoplastic variant. We describe for the first time p16 expression in trichilemmomas and discuss our findings in conjunction with p16 expression found in other cutaneous neoplasms. Additionally, the relationship of p16 to HPV infection is critically evaluated.

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“…They considered the outer sheath of the hair follicle as the site of origin of the lesion. [123] It is an uncommon tumor differentiating toward hair follicles, usually multiple and often familial with a disproportionate prevalence in females. [4] The lesions usually appear at puberty and are small rounded and rather translucent.…”

Section: Introductionmentioning

confidence: 99%

Multiple trichoepitheliomas: A rare occurrence

Karikal¹,

Shetty²,

Karikal³

et al. 2013

South Asian J Cancer

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Trichoepitelioma is an extremely rare cosmetically disfiguring condition usually affecting the females. Trichoepitheliomas are benign lesions seen on the face, which are thought to derive from the hair follicle. Malignant transformation to basal cell carcinoma is rare and occurs late in the course of the disease These lesions are often misinterpreted and diagnosed clinically as neurofibromatosis or histpathologically as basal cell carcinoma. We report a case of multiple trichoepithelioma occurring in a male patient. The patient presented with multiple dermatologic growths on the face with varied histopathological presentations which have been described in detail.

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Trichilemmoma. Analysis of 40 new cases

Cited by 46 publications

References 12 publications

A Case of Solitary Tricholemmoma

A Case of Solitary Tricholemmoma

p16 Expression in Conventional and Desmoplastic Trichilemmomas

Multiple trichoepitheliomas: A rare occurrence

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