Primary malignant hemangioendothelioma of the gingiva

Epithelioid hemangioendothelioma of the oral cavity: a case report

“…However, because of the lack of agreement relative to the terminology and criteria for true diagnosis of EHE and because the biologic behavior of these neoplasms differs depending on their anatomic positions and with regard to the age of occurrence, no consistent clinical or histologic criteria for predicting the biologic behavior of this vascular neoplasm in the oral region have yet been identified. However, some features considered suggestive of more aggressive clinical behavior include a mitotic rate more than one per 10 high-power fields, cellular atypia, focal necrosis, and increase in proportion of the spindle cells (3,7,8,20). Fortunately, the present case revealed the appearance of an intermediate lesion rather than a malignant lesion.…”

“…The microscopic differential diagnosis includes carcinoma, melanoma, epithelioid angiosarcoma, and epithelioid sarcoma, whereas, clinically, oral EHE can mimic benign reactive inflammatory conditions such as pyogenic granuloma (2,8).…”

“…It has a mortality rate of 13% for soft tissue lesions (9). EHE in the oral cavity is rare and only 26 cases have been reported to date (3,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). In many of these cases, the clinical impression was that of a benign lesion including pyogenic granuloma.…”

Epithelioid hemangioendothelioma of the oral cavity

“…The clinical impression of oral EHE was nonspecific, and most frequently appeared as a benign painless mass, although on occasions the lesion was ulcerated. If the tumour was close to the jaws, bony destruction was often observed on radiographic examination (Wesley et al , 1975; Ellis and Kratochvil, 1986; de Araujo et al , 1987; Marrogi et al , 1991; Hamakawa et al , 1999; Ramer et al , 2001; Molina Palma et al , 2002; Chi et al , 2005). To our best knowledge, the present series reported the first case located in the floor of mouth and the largest of intraoral EHE.…”

Epithelioid hemangioendothelioma of the tongue: a report of solitary and multiple lesions in two young children

“…tenascin, extracellular matrix molecules (Fig. 2d) which play important roles in the differentiation of endothelial cells (3). In addition, the tumor cells were positive for UEA-I binding, CD31 and von Willebrand factor, but not positive for S-100 protein, CD34, CD68, pan-cytokeratin (AE1/AE3), epithelial membrane antigen (EMA), melanoma-specific antigen (HMB45-reactive antigen) and desmin.…”