Epithelioid hemangioendothelioma of the oral cavity: a case report

Intraoral epithelioid hemangioendothelioma: A case report and review of the literature

“…The analysis of cases of intraoral epithelioid hemangioma reported in the literature is a relatively difficult task, once the lesion from years ago has received various names, such as "hemangioendothelioma", "malignant hemangioendothelioma" and "histiocytoid hemangioma" (7-9), thus, the reference point selected for the literature review presented here is the work published in 1975 by Wesley et al (8), entitled "Primary malignant hemangioendothelioma of the gingiva", until the most recent reported case by Mohtasham et al (10). (Table 2) shows the epidemiological data of the EHs reported in the literature in journals indexed in PubMed, including the case reported here.…”

“…The case reported here is consistent with the literature, once the hypothesis of clinical diagnosis was pyogenic granuloma. The fact that the majority of EHs are clinically diagnosed as benign lesions has a great relevance, since it is a neoplasm with malignant biological behavior, intermediate between the hemangioma and conventional angiosarcoma, with reported cases displaying aggressive behavior and multiples recurrences (10,12). It was noted that only 2 cases (7.4%) reported pain associated with the lesion, while the majority had no information about the symptoms, which leads us to infer that they were asymptomatic or that this was not just informed by authors ( Table 2).…”

Epithelioid hemangioendothelioma: 15 years at the National Cancer Institute. Literature review

“…The neoplasia occupies the tissue surrounding the vessels, which tend to be preserved, and it also fills in the lumen in the form of "tufts" (4,12,32,37) . Epithelioid cells are polygonal or round with wide eosinophilic cytoplasm, although foci of fusiform cells may be occasionally found (12,26,31) . It has round or ovoid vesicular nuclei, fine and dispersed chromatin, with no evident nucleoli.…”

“…In general, cellular atypia is discreet and the mitotic activity is low, although there may be significant atypia and high mitotic rate (> 1 mitosis/10 high power fields [HPF]). In association with the presence of necrosis and higher number of fusiform neoplastic cells, it may suggest a more aggressive clinical course , including distant metastasis (12,26,37) .…”

Urgent maxillectomy in infants for rare infantile maxillary tumors

“…However, because of the lack of agreement relative to the terminology and criteria for true diagnosis of EHE and because the biologic behaviors of these neoplasms differs depending on their anatomic positions and with regard to the age of recurrence, no consistent clinical or histological criteria for predicting the biologic behavior of this vascular neoplasm in the facial bone have been yet identified [19].…”