Primary large cell neuroendocrine carcinoma: A cause of extracardiac uptake site of Tc99m tetrofosmin

Thallium-201 versus Tc99m-glucoheptonate SPECT for evaluation of recurrent brain tumours: a within-subject comparison with pathological correlation

“…Unfortunately, the intracranial and pericranial biodistribution of Tc99m-sestamibi and Tc99m-tetrofosmin is not ideal for brain tumour imaging as both show intense uptake in the choroid plexus and in the temporalis and extraocular muscles which interferes significantly with brain tumour evaluation. 16,17 Moreover, tumours expressing P-glycoprotein, a product of the multidrug resistance genes, do not concentrate Tc99m-tetrofosmin or Tc99m-sestamibi at all. [18][19][20][21] Thus, Tc99m-sestamibi and Tc99m-tetrofosmin have proved disappointing as an alternative to Tl-201 for brain tumour imaging.…”