Focal Pulmonary Uptake During Tc-99m Myocardial Perfusion SPECT Imaging

Abstract

Although the incidence of abnormal pulmonary uptake during MSPECT was very low, the incidence of malignant lesions in the patients with nodular pulmonary uptake was relatively high.

Importance of systematic review of rotating projection images from Tc99m-sestamibi cardiac perfusion imaging for noncardiac findings

“…Similarly, focusing on abnormal pulmonary uptake during adenosine exams, Kim et al [36] reported an incidence of 2.9%, substantially higher than our adenosine incidence of 0.56% (P < 0.0001). Recent Large pericardial effusion seen as circumferential photopenia around heart (white arrows) in projectional image (right), and as thick rim of fluid density in pericardium (white arrows) in axial image from contrastenhanced computed tomography (left).…”

“…The highest likelihood of detection occurred when both Tl-201 and sestamibi demonstrated uptake. Earlier, Kim et al [36] conducted a retrospective study of 1371 patients undergoing either adenosine sestamibi or Tc99m tetrofosmin, evaluating the incidence and origin of abnormal focal pulmonary uptake. They found 38 (2.8%) patients with pulmonary scintigraphic findings, that is, pulmonary NCF.…”

Decreased myocardial perfusion SPECT lung-to-heart ratio: Lucent lungs

“…Increased 201-thallium, Tc-99m sestamibi, and Tc-99m sestamibi uptake in the lungs has been described extensively in the literature ( 1 , 2 , 3 , 4 , 5 ). Focally increased tracer uptake in the lungs has been associated with malignant tumors, benign lesions, infiltrate, atelectasis, and granulomatous disease ( 1 , 6 , 7 , 8 , 9 ). Diffusely increased tracer uptake in the lungs has been correlated with extent of coronary disease, left ventricular dysfunction, and also poor prognosis ( 1 , 5 , 10 , 11 , 12 , 13 ).…”

F-18-2-Fluoro-2-Deoxyglucose Positron Emission Tomography Compared to Technetium-99m Hexakis-2-Methoxyisobutyl Isonitrile Single Photon Emission Chest Tomography in the Diagnosis of Indeterminate Lung Lesions

“…At surgery, 3/6 cases present tumor necrosis, which may explain the absence of MIBI uptake due to poor vascularization or low mitochondrial content [19]. Thus, 99m Tc-MIBI is used as a sensitive indicator of myocardial cell viability because it does not accumulate in the ischemic myocardial tissue [20,21]. Finally, in the remaining 3 cases other factors should also be considered, such as metabolic and/or biological factors not evaluated in these patients [22,23].…”