Thallium-201 versus Tc99m-glucoheptonate SPECT for evaluation of recurrent brain tumours: a within-subject comparison with pathological correlation

Imaging modalities in high-grade gliomas: Pseudoprogression, recurrence, or necrosis?

“…42 Technetium provides better tumor delineation and higher energy photon, but intense uptake in choroid plexus, temporalis and extraocular muscles may interfere with image interpretation. 43 …”

Tumour progression or pseudoprogression? A review of post-treatment radiological appearances of glioblastoma

“…96 Similarly, 99m Tc-glucoheptonate provided more information on recurrent tumour including the tumour margins, extent, and intratumoural necrosis. 97 Limitations 201 Tl studies have a low spatial resolution and a relatively high radiation dose. Despite having a greater photon flux, 99m Tc-sestamibi radiotracer shows uptake in normal tissues of the choroid plexus and pituitary gland, which limits the sensitivity.…”

“…Although 99m Tc-tetrofosmin does not cross the BBB and 99m Tc-glucoheptonate provides more information on the extent and intratumoural necrosis of recurrent tumour, the availability is limited and more studies are required to establish the sensitivity and specificity. 96,97 Sequential imaging and combination of techniques So far, each technique has been assessed individually with imaging mainly at one point in time. In practice, techniques are often combined and changes assessed over time to give a greater overview of pathology.…”

Performance of SPECT in the differential diagnosis of glioma recurrence from radiation necrosis

“…The final 24 articles contained 28 studies, and four of these articles compared SPECT images with different radiotracers [22,29,30,35]. These studies included a total sample size of 893 patients (1163 scans) suspected of glioma recurrence after radiotherapy.…”