Performance of SPECT in the differential diagnosis of glioma recurrence from radiation necrosis

Zhang, Hui; i, L; Wu, Chen; Xu, Bainan

doi:10.1016/j.jocn.2014.06.102

Cited by 11 publications

(8 citation statements)

References 42 publications

(66 reference statements)

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“…Our study highlights the potential of SPECT imaging in clinical neuro-oncology. In fact, SPECT is frequently employed in clinical neuroscience: in the domain of neuro-oncology, recent meta-analyses of clinical studies demonstrate that SPECT, due to its high specificity, is perhaps the best imaging modality to differentiate between cerebral regions due to tumor recurrence or radiotherapy-induced necrosis [ 15 , 16 ]. Regarding TSPO imaging in particular, Awde et al proposed that TSPO imaging could serve as a molecular biomarker of glioma progression and even response to treatment [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model

et al. 2015

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BackgroundRecent research has demonstrated the potential of 18-kDa translocator protein (TSPO) to serve as a target for nuclear imaging of gliomas. The aim of this study was to evaluate SPECT imaging of GL26 mouse glioma using radioiodinated CLINDE, a TSPO-specific tracer.MethodsGL26 cells, previously transfected with an enhanced green fluorescent protein (EGFP)-expressing lentivirus, were stereotactically implanted in the striatum of C57/Bl6 mice. At 4 weeks post-injection, dynamic SPECT scans with [123I]CLINDE were performed. A displacement study assessed specificity of tracer binding. SPECT images were compared to results of autoradiography, fluorescence microscopy, in situ nucleic acid hybridization, histology, and immunohistochemistry. Western blotting was performed to verify TSPO production by the tumor.ResultsSpecific uptake of tracer by the tumor is observed with a high signal-to-noise ratio. Tracer uptake by the tumor is indeed 3.26 ± 0.32 times higher than that of the contralateral striatum, and 78% of the activity is displaceable by unlabeled CLINDE. Finally, TSPO is abundantly expressed by the GL26 cells.ConclusionsThe present study demonstrates the feasibility of [123I]CLINDE SPECT in translational studies and underlines its potential for clinical glioma SPECT imaging.

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Section: Discussionmentioning

confidence: 99%

SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model

et al. 2015

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“…The sensitivity and specificity of 99m Tc-methionine, FDG PET/CT, and contrast-enhanced MRI was 75.9% and 90%, 82.8% and 80%, and 87.1% and 30%, respectively [57]. In a meta-analysis that evaluated the diagnostic ability of SPECT in differentiating glioma recurrence from radiation necrosis, the pooled sensitivity was 89% and the specificity 88% [58]. Other promising tracers for SPECT to differentiate tumor recurrence from radiation necrosis include pentavalent technetium-99m dimercaptosuccinic acid (Tc-99m (V) DMSA) [59], bis-methionine-DTPA (Tc MDM) [60], and 99m-technetium glucoheptonate ( 99m Tc-GHA) [61].…”

Section: Diagnostic Imaging Modalitiesmentioning

confidence: 99%

Radiation Necrosis, Pseudoprogression, Pseudoresponse, and Tumor Recurrence: Imaging Challenges for the Evaluation of Treated Gliomas

Zikou

Sioka

Alexiou

et al. 2018

Contrast Media & Molecular Imaging

164

131

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Glioblastoma (GBM) is the most common primary malignant type of brain neoplasm in adults and carries a dismal prognosis. The current standard of care for GBM is surgical excision followed by radiation therapy (RT) with concurrent and adjuvant temozolomide-based chemotherapy (TMZ) by six additional cycles. In addition, antiangiogenic therapy with an antivascular endothelial growth factor (VEGF) agent has been used for recurrent glioblastoma. Over the last years, new posttreatment entities such as pseudoprogression and pseudoresponse have been recognized, apart from radiation necrosis. This review article focuses on the role of different imaging techniques such as conventional magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), dynamic contrast enhancement (DCE-MRI) and dynamic susceptibility contrast (DSE-MRI) perfusion, magnetic resonance spectroscopy (MRS), and PET/SPECT in differentiation of such treatment-related changes from tumor recurrence.

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“…The last decades this modality was repeatedly implemented for the detection of tumor recurrence or remnants in high grade gliomas and for brain tumors grading [19-23]. Furthermore, it was proved of significant value in the differentiation between tumor necrosis due to irradiation and recurrence in surgically treated high grade gliomas [24]. In our case, brain SPECT showed intense and homogenous uptake of the radiopharmaceutical with high SUV indicating the presence of a meningioma.…”

Section: Discussionmentioning

confidence: 69%

Magnetic Resonance Spectroscopy and Single-Photon Emission Computed Tomography in the Evaluation of Cerebral Tumors: A Case Report

et al. 2017

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In their daily clinical practice, physicians have to confront diagnostic dilemmas which cannot be resolved by the application of only one imaging technique. In this case report, we present a 66-year-old woman who was admitted to our institution for the surgical resection of a recently diagnosed brain tumor. The patient had a history of epileptic seizures and was hospitalized in the past for anti-phospholipid syndrome related to a non-Hodgkin lymphoma in remission. Magnetic resonance imaging (MRI) examination revealed an enhancing right parasagittal lesion with significant edema suggestive of a high grade glioma. Advanced MRI techniques including proton magnetic resonance spectroscopy (1H-MRS) showed findings compatible of glioma. An additional examination was performed as part of a protocol that we are routinely performing in our institution for all brain tumors including not only the gold standard advanced MRI techniques but also single-photon emission computed tomography (SPECT) with technetium-99m (Tc99m). Brain SPECT indicated the presence of a meningioma which was verified by the histopathology of the resected specimen. In conclusion, a multimodality approach for the pre-surgical assessment of brain tumors has significant advantages not only for the diagnosis but also for the evaluation of intracranial tumors histology.

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Performance of SPECT in the differential diagnosis of glioma recurrence from radiation necrosis

Cited by 11 publications

References 42 publications

SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model

SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model

Radiation Necrosis, Pseudoprogression, Pseudoresponse, and Tumor Recurrence: Imaging Challenges for the Evaluation of Treated Gliomas

Magnetic Resonance Spectroscopy and Single-Photon Emission Computed Tomography in the Evaluation of Cerebral Tumors: A Case Report

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