Primary intestinal diffuse large B-cell non-Hodgkin's lymphoma: Clinical features, management, and prognosis of 66 patients

Ibrahim, E. M.; Ezzat, A.; El-Weshi, A.; Martin, Justin M.; Khafaga, Yasser; Rabih, W. Al; Ajarim, Dahish; Al-Foudeh, M. O.; Zucca, Emanuele

doi:10.1023/a:1008389001990

Cited by 75 publications

(83 citation statements)

References 23 publications

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“…[1][2][3] Considerable information on primary gastric DLBCL is available, but there are insufficient data on the clinical features and outcomes of primary intestinal DLBCL because it is usually studied as a subgroup of GI lymphomas. 1,[3][4][5] Although a few reports focusing on primary intestinal DLBCL have been published, [6][7][8][9] the sample sizes were small, and the optimal treatment strategies specific for primary intestinal DLBCL have not been established. Various treatment approaches have been tried, such as systemic chemotherapy similar to that used to treat nodal DLBCL and primary surgical resection of intestinal lesions and postoperative chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

“…Various treatment approaches have been tried, such as systemic chemotherapy similar to that used to treat nodal DLBCL and primary surgical resection of intestinal lesions and postoperative chemotherapy. 6,10,11 However, the treatment of primary intestinal DLBCL is a controversial issue because none of the published studies was randomized and these studies used mainly Cytoxan, hydroxyrubicin, Oncovin, and prednisone (CHOP) as an adjuvant chemotherapy. The combined treatment of rituximab with CHOP (R-CHOP) is effective for treating nodal DLBCL, 12 and R-CHOP might improve the outcome of primary intestinal DLBCL.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of treatment strategies for patients with intestinal diffuse large B-cell lymphoma: surgical resection followed by chemotherapy versus chemotherapy alone

Kim

Kang

Kim

et al. 2011

Blood

125

136

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The aim of this retrospective cohort study was to analyze the impact of surgery on the outcomes and qualities of life (QOL) in patients with intestinal diffuse large B-cell lymphoma (DLBCL). We assessed 345 patients with either localized or disseminated intestinal DLBCL and compared them according to treatment: surgical resection followed by chemotherapy versus chemotherapy alone. In patients with localized disease (Lugano stage I/II), surgery plus chemotherapy yielded a lower relapse rate (15.3%) than did chemotherapy alone (36.8%, P < .001). The 3-year overall survival rate was 91% in the surgery plus chemotherapy group and 62% in the chemotherapy-alone group (P < .001). The predominant pattern in the chemotherapy group was local relapse (27.6%). When rituximab was used with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP), there was no improvement of the outcomes in patients treated with primary surgical resection. The QOL of patients who underwent surgery and chemotherapy was lower than chemotherapy alone, but its difference was acceptable. Multivariate analysis showed that surgical resection plus chemotherapy was an independent prognostic factor for overall survival. Surgical resection followed by chemotherapy might be an effective treatment strategy with acceptable QOL deterioration for localized intestinal DLBCL. This study was registered at www.clinicaltrials.gov as #NCT01043302. (Blood. 2011;117(6): [1958][1959][1960][1961][1962][1963][1964][1965]

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of treatment strategies for patients with intestinal diffuse large B-cell lymphoma: surgical resection followed by chemotherapy versus chemotherapy alone

Kim

Kang

Kim

et al. 2011

Blood

125

136

View full text Add to dashboard Cite

show abstract

“…Treatment approaches are similar to those for high-grade aggressive lymphomas, and in addition to surgery, various chemotherapy regimens are administered. The mean survival rate has been reported to be approximately 20-30 months after initial diagnosis (2,4,11,12,20).…”

Section: Discussionmentioning

confidence: 99%

Primary intestinal diffuse large B-cell lymphoma forming multiple lymphomatous polyposis

Barut

Kandemır²,

Karakaya³

et al. 2011

Turk J Gastroenterol

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“…If the primary small bowel lymphoma is diagnosed before or at laparotomy, surgical resection should be preferred in order to limit the risk of serious complications, such as perforation, bleeding and obstruction. In early-stage patients, complete resection surgery is more advantageous in some reports [21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Non-Hodgkin’s lymphoma revealed by an ilio-colic intussusception in a Moroccan patient: a case report

Hassani¹,

Bouhaddouti²,

Ousadden³

et al. 2010

Pan Afr Med Jrnl

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Intussusceptions are rare but well-known causes of the small bowel obstruction in adults and an underlying cause is present in the majority of cases. Lymphoma's involvement of the ileum is one of the rare causes of intussusception. CT is a sensitive examination that diagnoses intussusceptions and provides an excellent preoperative evaluation including possible extension and dissemination especially in intestinal lymphomas. The treatment is almost always surgical and the pathological study is needed for diagnostic confirmation. Authors present an unusual case of intestinal intussusception due to lymphoma of the terminal part of the ileum in a 49-year-old man. Computed tomography confirmed the diagnosis of intussusception and non-Hodgkin's lymphoma of B-cell was diagnosed by histological examination after surgical treatment. Primary intestinal lymphomas differ from gastric lymphomas in clinical features, treatment, and prognosis. They are not well characterized and the standardized concepts for their clinical diagnosis and management are absent. The aim of this rare observation is to shed light on NHL of the small bowel, its clinical and radiological diagnosis and its treatment especially in forms revealed by intussusceptions in adults.

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Primary intestinal diffuse large B-cell non-Hodgkin's lymphoma: Clinical features, management, and prognosis of 66 patients

Cited by 75 publications

References 23 publications

Comparison of treatment strategies for patients with intestinal diffuse large B-cell lymphoma: surgical resection followed by chemotherapy versus chemotherapy alone

Comparison of treatment strategies for patients with intestinal diffuse large B-cell lymphoma: surgical resection followed by chemotherapy versus chemotherapy alone

Primary intestinal diffuse large B-cell lymphoma forming multiple lymphomatous polyposis

Non-Hodgkin’s lymphoma revealed by an ilio-colic intussusception in a Moroccan patient: a case report

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