Comparison of treatment strategies for patients with intestinal diffuse large B-cell lymphoma: surgical resection followed by chemotherapy versus chemotherapy alone

Kim, Seok Jin; Kang, Hye Jin; Kim, Jin Seok; Oh, Sung Yong; Choi, Chul Won; Lee, Soon Il; Won, Jong Ho; Kim, Min Kyoung; Kwon, Jung Hye; Mun, Yeung Chul; Kwak, Jae Yong; Kwon, Jieun; Hwang, In Gyu; Kim, Hyo Jung; Park, Jinny; Oh, Sukjoong; Huh, Jooryung; Ko, Young Hyeh; Suh, Cheolwon; Kim, Won Seog

doi:10.1182/blood-2010-06-288480

Cited by 125 publications

(152 citation statements)

References 23 publications

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“…A recent Chinese study (n = 116) reported that in addition to female sex and B-cell phenotype, radical surgery was an independent prognostic factor for better OS, as determined by multivariate analysis [27]. Another large study from Korea on 345 patients with intestinal DLBCL revealed that among stage I/II 1 patients, those treated by surgery plus chemotherapy (CHOP or R-CHOP) showed significantly better survivals than those treated by chemotherapy alone [28]. In addition, multivariate analysis revealed that surgery plus chemotherapy was a sole independent prognostic factor for better OS [28].…”

Section: Treatment For Gastrointestinal Lymphomamentioning

confidence: 99%

Gastrointestinal Lymphoma: Recent Advances in Diagnosis and Treatment

Nakamura¹,

Matsumoto²

2013

Digestion

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The recent trends in the diagnosis and management of gastrointestinal lymphoma are reviewed. Primary gastrointestinal lymphoma accounts for 30-40% of all extranodal lymphomas, while it comprises only 1-8% of all gastrointestinal malignancies. The most common histological type is mucosa-associated lymphoid tissue lymphoma, followed by diffuse large B-cell lymphoma. Recently, the incidence of intestinal follicular lymphoma has been increasing. Balloon-assisted endoscopy and capsule endoscopy are essential tools for the assessment of small bowel lymphomas. Treatment modalities for gastrointestinal lymphomas include ‘watch and wait' strategy, antibiotics (e.g. Helicobacter pylori eradication), radiotherapy, chemotherapy, surgical resection, immunotherapy (e.g. rituximab), and combinations of these. Optimal therapeutic strategies should be determined based on the involved site, histological type, and clinical stage. It should be noted that accurate pretreatment diagnosis of the disease is most important.

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Section: Treatment For Gastrointestinal Lymphomamentioning

confidence: 99%

Gastrointestinal Lymphoma: Recent Advances in Diagnosis and Treatment

Nakamura¹,

Matsumoto²

2013

Digestion

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“…Among patients with localized diseases, the relapse rate was lower in patients receiving chemotherapy following surgical resection than in patients receiving chemotherapy alone. The survival rate of 3 years following treatment was also significantly high in patients receiving chemotherapy following surgical resection (p<0.001) (2). Surgical resection and CHOP chemotherapy were performed in patients diagnosed with localized DLBCL in the ileocecal region.…”

Section: Discussionmentioning

confidence: 99%

“…Among these cases, lymphomas with extra-nodal involvement may be seen. However, an increasing number of recent publications indicate that chemotherapy, added to surgical resection, in local mass lymphoma is more successful than chemotherapy alone (2). These rare cases may occasionally present with abdominal pain, abdominal mass, and acute abdomen.…”

Section: Introductionmentioning

confidence: 99%

Diffuse Large B-cell Lymphoma Transformed from MALT Lymphoma Presented by Acute Abdomen

Çetin¹,

Karatoprak²,

Cevirme³

et al. 2015

Bezmialem Science

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Non-Hodgkin lymphomas constitute 1% of gastrointestinal system tumors. Lymphomas can occur from the oral cavity to the rectum. Primary gastrointestinal lymphomas are most frequent in the stomach, followed by the small and large intestines. Here, we report a 41-year-old male patient who had been under chemotherapy following a diagnosis of diffuse large B-cell lymphoma transformed from MALT lymphoma and discuss new treatment options. He presented to us with an acute abdomen. To our knowledge, this was the first case in the literature that presented with acute abdomen and was diagnosed as diffuse large B-cell lymphoma that transformed from MALT lymphoma. In addition, for the treatment, we want to draw attention to the importance of surgery, in addition to chemotherapy.Key Words: Maltoma, diffuse large B-cell lymphoma, acute abdomen, ileus ÖZET Non-Hodgkin Lenfomalar (NHL) gastrointestinal sistem (GİS) malin tümörlerinin %1'ini oluşturur. Lenfomalar GİS'in, oral kaviteden rektuma kadar her hangi bir yerinde oluşabilir. Primer gastrointestinal lenfomaların mideden sonra en sık görül-düğü alan ince ve kalın barsaklardır. Akut batın tablosu ile gelen MALT lenfomadan transforme olmuş diffuz büyük B hücreli lenfoma tanısı konularak kemoterapi başlanan 41 yaşındaki erkek hasta sunulmuş ve tedavi seçenekleri tartışılmıştır. Literatür-de akut batın tablosu ile gelen ve lenfoma tanısı konulan vakalar içinde MALT lenfomadan transforme olmuş diffuz B hücreli lenfoma tanısına rastlamadık. Ayrıca son yıllarda yapılan çalış-malarda vurgulanan kemoterapinin yanında cerrahinin önemine dikkat çekilmiştir.Anahtar Sözcükler: Maltoma, diffuz büyük B hüçreli lenfoma, akut batın, ileus

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“…Seokjinkim et all in 2011 concluded that combination of surgery and chemotherapy improves survival in localized disease. [4] Whereas Beaton C et al, in their study in 2012 haverecommended that chemotherapy be the principal mode of treatment and surgery be reserved for patients with clinical indication. [5] Our patient was treated with chemotherapy, and surgery was deferred since there was no evidence of obstruction.…”

Section: Diagnosismentioning

confidence: 99%