Primary intestinal diffuse large B-cell lymphoma forming multiple lymphomatous polyposis

Barut, Figen; Kandemır, Nilüfer Onak; Karakaya, Kemal; Kökten, Neslihan; Özdamar, Şükrü Oğuz

doi:10.4318/tjg.2011.0220

Cited by 3 publications

(2 citation statements)

References 17 publications

(29 reference statements)

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“…Primary GI lymphoma can involve any part of the GI tract, but the stomach and small intestine are the most common sites, and the most commonly encountered histologic subtypes are DLBCL and MALT lymphoma [4,8,10]. While many unusual presentations of gastrointestinal DLBCL have been described, presentation with obstructive jaundice and very high CA 19-9 level has not been previously reported [5][6][7]. Abdominal pain, weight loss, obstructive jaundice, and high CA 19-9 level are common presentations of advanced pancreatic carcinoma [11].…”

Section: Discussionmentioning

confidence: 97%

“…Common presentations include abdominal pain, weight loss, nausea, vomiting, and complications such as intestinal obstruction or perforations and gastrointestinal bleeding [1,4]. While many unusual presentations have been described, presentation with obstructive jaundice and a very high CA 19-9 level has not been previously reported [5][6][7]. We report a case of advanced gastrointestinal DLBCL presenting with obstructive jaundice and a very high CA 19-9 level mimicking adenocarcinoma of the pancreas.…”

Section: Introductionmentioning

confidence: 93%

See 1 more Smart Citation

Advanced Gastrointestinal Diffuse Large B-Cell Lymphoma Presenting with Obstructive Jaundice and Very High CA 19-9 Level Mimicking Pancreatic Adenocarcinoma

Adekolujo

Agu

Shamar

et al. 2015

J Gastrointest Canc

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 93%

Advanced Gastrointestinal Diffuse Large B-Cell Lymphoma Presenting with Obstructive Jaundice and Very High CA 19-9 Level Mimicking Pancreatic Adenocarcinoma

Adekolujo

Agu

Shamar

et al. 2015

J Gastrointest Canc

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Rare gastrointestinal lymphomas: The endoscopic investigation

Vetro

Bonanno

Giulietti

et al. 2015

WJGE

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Gastrointestinal lymphomas represent up to 10% of gastrointestinal malignancies and about one third of non-Hodgkin lymphomas. The most prominent histologies are mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma. However, the gastrointestinal tract can be the site of rarer lymphoma subtypes as a primary or secondary localization. Due to their rarity and the multifaceted histology, an endoscopic classification has not been validated yet. This review aims to analyze the endoscopic presentation of rare gastrointestinal lymphomas from disease diagnosis to follow-up, according to the involved site and lymphoma subtype. Existing, new and emerging endoscopic technologies have been examined. In particular, we investigated the diagnostic, prognostic and follow-up endoscopic features of T-cell and natural killer lymphomas, lymphomatous polyposis and mantle cell lymphoma, follicular lymphoma, plasma cell related disease, gastrointestinal lymphomas in immunodeficiency and Hodgkin's lymphoma of the gastrointestinal tract. Contrarily to more frequent gastrointestinal lymphomas, data about rare lymphomas are mostly extracted from case series and case reports. Due to the data paucity, a synergism between gastroenterologists and hematologists is required in order to better manage the disease. Indeed, clinical and prognostic features are different from nodal and extranodal or the bone marrow (in case of plasma cell disease) counterpart. Therefore, the approach should be based on the knowledge of the peculiar behavior and natural history of disease.

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A Unique Presentation of Primary Intestinal MALT Lymphoma as Multiple Lymphomatous Polyposis

Palo

Biligi

2016

JCDR

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A 68-year-old male was admitted to Surgery department of the college with complaints of easy fatigability, pain abdomen & diarrhea since one year. He also complained of blood in stool, on and off, for last three months. His general physical and systemic examination & laboratory findings were normal except for an elevated ESR (=90 mm at the end of first hour) and anemia (hemoglobin 9.5 gm %). Chest X -ray was within normal limits. Colonoscopic biopsy was done at a different clinic, six months prior to his admission, and the microscopic examination showed "ulcerated colonic mucosa with granulation tissue, heavy mononuclear cell infiltrate and no evidence of malignancy." Subsequently, computer tomography of the abdomen was advised. It revealed circumferential wall thickening with intramural mass involving caecum & ascending colon along with multiple enlarged pericolonic lymph nodes. There was no hepatosplenomegaly. A provisional diagnosis of colonic carcinoma was made and the patient underwent right hemicolectomy.The resected specimen received in our pathology department was that of a colonic segment measuring 45cms in length, with the mucosal aspect being studded with a multitude of sessile polyps of varying sizes, largest measuring 3.5 x 2.5 x 1.8 cm [ ABSTRACTMultiple lymphomatous polyposis is considered to be a rare condition, with most of the cases being extranodal counterpart of mantle cell lymphomas. We report a rare case of multiple lymphomatous polyposis of the gastrointestinal tract in which the patient presented with abdominal pain and bloody diarrhea. Computer tomography of the abdomen showed circumferential wall thickening with intramural mass involving caecum & ascending colon with enlarged pericolonic lymph nodes. The patient underwent right hemicolectomy.Immunohistologic findings were characteristic of MALT lymphoma. Microscopic examination of polypoidal masses and mesenteric lymph nodes revealed infiltration by pleomorphic, atypical lymphoid cells which were CD20 positive and negative for CD3, CD10, Cyclin D1. Lymphoepithelial lesions were also noted. Careful endoscopic evaluation and histopathological review along with an immunohistochemical panel is extremely useful for accurately diagnosing such cases and avoiding unnecessary surgery and inappropriate therapy.

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Primary intestinal diffuse large B-cell lymphoma forming multiple lymphomatous polyposis

Cited by 3 publications

References 17 publications

Advanced Gastrointestinal Diffuse Large B-Cell Lymphoma Presenting with Obstructive Jaundice and Very High CA 19-9 Level Mimicking Pancreatic Adenocarcinoma

Advanced Gastrointestinal Diffuse Large B-Cell Lymphoma Presenting with Obstructive Jaundice and Very High CA 19-9 Level Mimicking Pancreatic Adenocarcinoma

Rare gastrointestinal lymphomas: The endoscopic investigation

A Unique Presentation of Primary Intestinal MALT Lymphoma as Multiple Lymphomatous Polyposis

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