Primary Infertility and Uterine Anomalies

Heinonen, Pentti K.; Pystynen, P

doi:10.1097/00006254-198403000-00019

Cited by 24 publications

(28 citation statements)

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“…18 It is not clear whether gestational capacity is more or less compromised when a rudimentary horn is present. 19,20 Heinonen reported that ectopic pregnancy occurred in 22% of unicornuate uterus and rudimentary horn cases.…”

Section: Discussionmentioning

confidence: 99%

“…19,20 Heinonen reported that ectopic pregnancy occurred in 22% of unicornuate uterus and rudimentary horn cases. 18 As a result of a high number of ectopic pregnancies, he suggested the removal of the rudimentary horn in unicornuate uterus cases with communicating rudimentary horn once the diagnosis is confirmed. In our study, the number of ectopic pregnancies was three out of six unicornuate uterus cases with a communicating horn.…”

Section: Discussionmentioning

confidence: 99%

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Reproductive outcome of women with unicornuate uterus

Akar

Bayar

Yıldız

et al. 2005

Aust NZ J Obst Gynaeco

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This study was undertaken to examine the reproductive impact of unicornuate uterine abnormalities cases in a group of 571 women with a uterine anomaly. Hospital records of 1784 patients who presented to the infertility outpatient clinic with infertility, recurrent pregnancy loss, pain or acute abdomen during the study period between January 1991 and January 2001, were reviewed retrospectively. The reproductive performance of women with unicornuate uterus was poor, with a live birth rate of only 29.2%, prematurity rate of 44%, miscarriage rate of 29%, and an ectopic pregnancy rate of 4%.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Reproductive outcome of women with unicornuate uterus

Akar

Bayar

Yıldız

et al. 2005

Aust NZ J Obst Gynaeco

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show abstract

“…On average worldwide, 72.4 million or 9% of women at the reproductive age are infertile [1]. The infertility can be attributed to various reasons such as: ovulatory dysfunction [2], [3], tubal diseases [4], [5], endometriosis [6]–[8] and uterine malformations [9], [10]. A common infertility treatment is assisted reproductive technology (ART), which can work for ovulatory and tubal disorders but not for uterine abnormalities.…”

Section: Introductionmentioning

confidence: 99%

Application of Detergents or High Hydrostatic Pressure as Decellularization Processes in Uterine Tissues and Their Subsequent Effects on In Vivo Uterine Regeneration in Murine Models

et al. 2014

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Infertility caused by ovarian or tubal problems can be treated using In Vitro Fertilization and Embryo Transfer (IVF-ET); however, this is not possible for women with uterine loss and malformations that require uterine reconstruction for the treatment of their infertility. In this study, we are the first to report the usefulness of decellularized matrices as a scaffold for uterine reconstruction. Uterine tissues were extracted from Sprague Dawley (SD) rats and decellularized using either sodium dodecyl sulfate (SDS) or high hydrostatic pressure (HHP) at optimized conditions. Histological staining and quantitative analysis showed that both SDS and HHP methods effectively removed cells from the tissues with, specifically, a significant reduction of DNA contents for HHP constructs. HHP constructs highly retained the collagen content, the main component of extracellular matrices in uterine tissue, compared to SDS constructs and had similar content levels of collagen to the native tissue. The mechanical strength of the HHP constructs was similar to that of the native tissue, while that of the SDS constructs was significantly elevated. Transmission electron microscopy (TEM) revealed no apparent denaturation of collagen fibers in the HHP constructs compared to the SDS constructs. Transplantation of the decellularized tissues into rat uteri revealed the successful regeneration of the uterine tissues with a 3-layer structure 30 days after the transplantation. Moreover, a lot of epithelial gland tissue and Ki67 positive cells were detected. Immunohistochemical analyses showed that the regenerated tissues have a normal response to ovarian hormone for pregnancy. The subsequent pregnancy test after 30 days transplantation revealed successful pregnancy for both the SDS and HHP groups. These findings indicate that the decellularized matrix from the uterine tissue can be a potential scaffold for uterine regeneration.

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“…[6] schlussfolgerten aus ihrer Untersuchung, dass Uterusfehlbildungen selten Ursache fu Èr eine prima Ère Sterilita Èt sind und empfahlen daher vor einer Metroplastik in jedem Fall den Ausschluss anderer Sterilita Ètsursachen. Derzeit existieren keine prospektiv randomisierten Studien, die den Vorteil der Operation fu Èr die Patientin hinsichtlich des Schwangerschaftseintrittes beweisen.…”

Section: Diskussionunclassified

Uterus septus bei primärer Sterilität - eine Operationsindikation?

Nawroth¹,

Schmidt²,

Freise³

et al. 2001

Zentralbl Gynakol

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The hysteroscopic metroplasty demonstrates a low intra- and postoperative rate of complication. Particularly the indication of a lower rate of miscarriages, possibly of an increase in the pregnancy rates, should, in our opinion, give reason to proceeding with a diagnostic hysteroscopy, especially prior to extensive sterility therapies. Where suspicion exists of a septum > 1.0 cm, this should be corrected by means of an operative hysteroscopy.

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Primary Infertility and Uterine Anomalies

Cited by 24 publications

References 0 publications

Reproductive outcome of women with unicornuate uterus

Reproductive outcome of women with unicornuate uterus

Application of Detergents or High Hydrostatic Pressure as Decellularization Processes in Uterine Tissues and Their Subsequent Effects on In Vivo Uterine Regeneration in Murine Models

Uterus septus bei primärer Sterilität - eine Operationsindikation?

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