Prieurianin Causes Weight Loss in Diet-Induced Obese Mice and Inhibits Adipogenesis in Cultured Preadipocytes

Kablan, Ahmed; Saunders, Rudel A.; Szkudlarek-Mikho, Maria; Chin, Andrew J.B.; Bosio, Raul M.; Fujii, Kazuyuki; Shapiro, Joseph I.; Chin, Khew‐Voon

doi:10.4172/2155-6156.1000101

Cited by 16 publications

(13 citation statements)

References 25 publications

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“…Diabetes is one of the most important public health challenges for the 21 st century [42]. Diabetes mellitus is associated with an increased risk for a number of serious and sometimes life-threatening diseases like cardiovascular disease [43,44], peripheral vascular disease, and cerebrovascular disease [45,46]. The high blood sugar level produces some of the symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger) [47].…”

Section: Diabetesmentioning

confidence: 99%

Role of Diabetes in prevalence of Tuberculosis

Siddiqui¹

2012

J Diabetes Metab

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Tuberculosis is a lethal disease caused by Mycobacterium tuberculosis. The Mycobacterium initially infects lungs. If the infection spreads beyond the lungs, the symptoms will depend upon the individual organs. Diabetes is a type of metabolic disease in which a person has increased blood sugar level. It's because the body does not produce enough insulin or the cells inside the body do not respond to the insulin that is produced. Diabetics have a three to five time's higher risk of developing tuberculosis (TB) than those without diabetes disease. Diabetes mellitus is an important risk factor for tuberculosis and may affect disease treatment and also the response. Additionally tuberculosis may induce glucose intolerance and worsen the glycaemic control in people with diabetes. The main aim of this Review is to evaluate the epidemiology of diabetes mellitus and tuberculosis disease, the effect of diabetes mellitus on tuberculosis and vice versa.  When the immune system of a patient with dormant TB is weakened, the TB can become active (reactivate) and cause infection in lungs or any other parts of the body. The risk factors for acquiring TB include close-contact situations, alcohol, drug abuse and certain diseases (examples include diabetes, cancer, and HIV) and occupations (for example, health-care workers). The common signs and symptoms of TB include fatigue, fever, weight loss, coughing, and night sweats. The diagnosis of TB involves skin tests, chest X-rays, sputum analysis (smear and culture), and PCR tests to detect the genetic material of the causative bacteria or causative agent [12]. Inactive tuberculosis may be treated with an isoniazid (INH), antibiotic, in order to prevent the TB infection from becoming active. Active TB is usually treated, successfully, with INH in combination with one or more of several drugs, including rifampin (Rifadin), ethambutol (Myambutol), pyrazinamide, and streptomycin [13].

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Section: Diabetesmentioning

confidence: 99%

Role of Diabetes in prevalence of Tuberculosis

Siddiqui¹

2012

J Diabetes Metab

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“…Apoptosis was monitored as described [13] by the Guava Nexin assay on the Guava cytometer according to manufacturer’s specification (EMD Millipore, Billerica, MA). The assay measures membrane changes associated with apoptosis using Annexin V-PE and 7-aminoactinomycin D to identify dead cells.…”

Section: Methodsmentioning

confidence: 99%

Salinomycin, a polyether ionophoric antibiotic, inhibits adipogenesis

Szkudlarek-Mikho¹,

Saunders²,

Yap³

et al. 2012

Biochemical and Biophysical Research Communications

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The polyether ionophoric antibiotics including monensin, salinomycin, and narasin, are widely used in veterinary medicine and as food additives and growth promoters in animal husbandry including poultry farming. Their effects on human health, however, are not fully understood. Recent studies showed that salinomycin is a cancer stem cell inhibitor. Since poultry consumption has risen sharply in the last three decades, we asked whether the consumption of meat tainted with growth promoting antibiotics might have effects on adipose cells. We showed in this report that the ionophoric antibiotics inhibit the differentiation of preadipocytes into adipocytes. The block of differentiation is not due to the induction of apoptosis nor the inhibition of cell proliferation. In addition, salinomycin also suppresses the transcriptional activity of the CCAAT/enhancer binding proteins and the peroxisome proliferator-activated receptor γ. These results suggest that the ionophoric antibiotics can be exploited as novel anti-obesity therapeutics and as pharmacological probes for the study of adipose biology. Further, the pharmacological effects of salinomycin could be a harbinger of its toxicity on the adipose tissue and other susceptible target cells in cancer therapy.

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“…Once Stem cells are appropriately differentiated they could correct many diseases and degenerative conditions in which bone or cartilage cells are deficient in numbers or defective in function which can be used for treatment of genetic disorders such as osteogenesis imperfecta and chondrodysplasias [93]. Mesenchymal stem cells have been identified in bone marrow as non-hematopoietic stem cells that may differentiate in to tissues of mesodermal origin such as adipocytes [94,95] ostoblasts, stromal cells, and chondrocytes. These cells can differentiate in to tissues of ectodermal and endodermal origin such as hepatocytes [96].…”

Section: Stem Cells In Diseases Of Bone and Cartilagementioning

confidence: 99%

A Review on Stem cell Research & Their Role in Various Diseases

R¹,

D²,

Nishanth³

2011

J Stem Cell Res Ther

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Stem cells likely play key roles in the repair of diverse injuries or disorders in body. Recent advances in biotechnology and regenerative medicine brought a revolutionary change in the practice of medicine. Advancements in stem cell biology, including embryonic and postnatal somatic stem cells, have made the prospect of tissue regeneration a potential clinical reality. Absolute concept for the use of stem cells in bone disorders has been centered on the strategies for reconstructing segmental regions of the skeleton, lost to trauma or surgery, and in muscle diseases, to provide normal population of cells in order to replace defective tissue.

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Prieurianin Causes Weight Loss in Diet-Induced Obese Mice and Inhibits Adipogenesis in Cultured Preadipocytes

Cited by 16 publications

References 25 publications

Role of Diabetes in prevalence of Tuberculosis

Role of Diabetes in prevalence of Tuberculosis

Salinomycin, a polyether ionophoric antibiotic, inhibits adipogenesis

A Review on Stem cell Research & Their Role in Various Diseases

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