Enuresis (bedwetting) is a common disorder in which children wet the bed consciously while they should have had control of the bladder. Prevention of this case is highly important, hence the impact of enuresis on child development can be overcome. Family history, psychological stress, constipation, and poor toilet training can lead to enuresis. This study aims to discover factors related to enuresis in children aged 5-6 years in Padang City. The research type is quantitative with the method is analytic and an approach of cross-sectional study. The samples used in this study involved 178 children who were 5 and six years old. These were taken by applying incidental sampling technique. The data collection tool was questionnaires including several factors regarding enuresis in children; this consisted of a family history questionnaire (IACAPAP), psychological stress (PSS-C), constipation, toilet training, and other questionnaires. The data analysis used was a Chi-square test. The results showed that less than half of a total number of the children had enuresis (34.8%) and there was a relation among family history, constipation, toilet training (p-value = 0.000) and psychological stress (p-value = 0.003) with enuresis in children. This thesis suggests that parents should pay more attention to their children's health such as stress and constipation, and nurses as educators are expected to provide information for parents about stress, constipation and implementation of toilet training in children in order to reduce the incidence of enuresis.